TY - JOUR
T1 - Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography
AU - Fouad, Ali
AU - Shaykoon, Montaser Sh. A.
AU - Ibrahim, Samy M.
AU - El-Adl, Sobhy M.
AU - GHANEM, Ashraf
N1 - Funding Information:
Funding: This research was supported, in part, by Al-Azhar University, Egypt and University of Canberra, Australia. Funding was supported by the Egyptian Cultural and Educational Bureau, Minister of Higher Education Egypt (Cultural Affairs and Missions Sector) as Ph.D. joint mission stipend offered to Ali Fouad.
Funding Information:
This research was supported, in part, by Al-Azhar University, Egypt and University of Canberra, Australia. Funding was supported by the Egyptian Cultural and Educational Bureau, Minister of Higher Education Egypt (Cultural Affairs and Missions Sector) as Ph.D. joint mission stipend offered to Ali Fouad.
Publisher Copyright:
© 2019 by the authors.
PY - 2019
Y1 - 2019
N2 - A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.
AB - A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.
KW - Capillary chromatography
KW - Colistin sulfate
KW - Enantioselective
KW - Encapsulation
KW - Monolith
KW - Organic polymer
KW - encapsulation
KW - monolith
KW - organic polymer
KW - capillary chromatography
KW - colistin sulfate
KW - enantioselective
KW - Pharmaceutical Preparations/chemical synthesis
KW - Solvents
KW - Nitriles/chemistry
KW - Stereoisomerism
KW - Capillary Electrochromatography/methods
KW - Polymers/chemistry
KW - Epoxy Compounds/chemistry
KW - Methacrylates/chemistry
KW - Colistin/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85062855986&partnerID=8YFLogxK
UR - http://www.mdpi.com/1420-3049/24/5/833
UR - http://www.mendeley.com/research/colistin-sulfate-chiral-stationary-phase-enantioselective-separation-pharmaceuticals-using-organic-p
U2 - 10.3390/molecules24050833
DO - 10.3390/molecules24050833
M3 - Article
C2 - 30813595
SN - 1420-3049
VL - 24
SP - 833
EP - 849
JO - Molecules
JF - Molecules
IS - 5
ER -