Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography

Ali Fouad, Montaser Sh. A. Shaykoon, Samy M. Ibrahim, Sobhy M. El-Adl, Ashraf GHANEM

Research output: Contribution to journalArticle

Abstract

A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.
LanguageEnglish
Article number833
Pages833
Number of pages15
JournalMolecules
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Jan 2019

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Colistin
Organic polymers
Chromatography
Pharmaceutical Preparations
Dopamine Uptake Inhibitors
Anti-Bacterial Agents
1-Propanol
Anti-Arrhythmia Agents
Liquid chromatography
Hypnotics and Sedatives
Copolymerization
Catecholamines
Norepinephrine
Polymers
Anti-Inflammatory Agents
Monomers

Cite this

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title = "Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography",
abstract = "A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.",
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Colistin Sulfate Chiral Stationary Phase for the Enantioselective Separation of Pharmaceuticals Using Organic Polymer Monolithic Capillary Chromatography. / Fouad, Ali; Shaykoon, Montaser Sh. A.; Ibrahim, Samy M.; El-Adl, Sobhy M.; GHANEM, Ashraf.

In: Molecules, Vol. 24, No. 5, 833, 01.01.2019, p. 833.

Research output: Contribution to journalArticle

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