Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function

The Sun Exposure and Vitamin D Supplementation (SEDS) Study

Mica Hartley, Samuel Hoare, Fiona LITHANDER, Rachel Neale, Prue Hart, Shelley Gorman, Peter Gies, Jill Sherriff, Ashwin Swaminathan, Lawrence Beilin, Trevor Mori, Laura King, Lucinda Black, Kushani Marshall, Fan Xiang, Candy Wyatt, Kerryn King, Terry Slevin, Nirmala Pandeya, Robyn Lucas

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Background: Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. Methods/Design: The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. Discussion: This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention.
    Original languageEnglish
    Article number115
    Pages (from-to)1-9
    Number of pages9
    JournalBMC Public Health
    Volume15
    Issue number1
    DOIs
    Publication statusPublished - 10 Feb 2015

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    Solar System
    Vitamin D
    Vitamin D Deficiency
    Skin Neoplasms
    Serum
    Climate
    Compliance
    Randomized Controlled Trials
    Biomarkers
    Placebos

    Cite this

    Hartley, Mica ; Hoare, Samuel ; LITHANDER, Fiona ; Neale, Rachel ; Hart, Prue ; Gorman, Shelley ; Gies, Peter ; Sherriff, Jill ; Swaminathan, Ashwin ; Beilin, Lawrence ; Mori, Trevor ; King, Laura ; Black, Lucinda ; Marshall, Kushani ; Xiang, Fan ; Wyatt, Candy ; King, Kerryn ; Slevin, Terry ; Pandeya, Nirmala ; Lucas, Robyn. / Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function : The Sun Exposure and Vitamin D Supplementation (SEDS) Study. In: BMC Public Health. 2015 ; Vol. 15, No. 1. pp. 1-9.
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    title = "Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: The Sun Exposure and Vitamin D Supplementation (SEDS) Study",
    abstract = "Background: Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. Methods/Design: The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. Discussion: This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention.",
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    author = "Mica Hartley and Samuel Hoare and Fiona LITHANDER and Rachel Neale and Prue Hart and Shelley Gorman and Peter Gies and Jill Sherriff and Ashwin Swaminathan and Lawrence Beilin and Trevor Mori and Laura King and Lucinda Black and Kushani Marshall and Fan Xiang and Candy Wyatt and Kerryn King and Terry Slevin and Nirmala Pandeya and Robyn Lucas",
    year = "2015",
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    doi = "10.1186/s12889-015-1461-7",
    language = "English",
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    Hartley, M, Hoare, S, LITHANDER, F, Neale, R, Hart, P, Gorman, S, Gies, P, Sherriff, J, Swaminathan, A, Beilin, L, Mori, T, King, L, Black, L, Marshall, K, Xiang, F, Wyatt, C, King, K, Slevin, T, Pandeya, N & Lucas, R 2015, 'Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: The Sun Exposure and Vitamin D Supplementation (SEDS) Study', BMC Public Health, vol. 15, no. 1, 115, pp. 1-9. https://doi.org/10.1186/s12889-015-1461-7

    Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function : The Sun Exposure and Vitamin D Supplementation (SEDS) Study. / Hartley, Mica; Hoare, Samuel; LITHANDER, Fiona; Neale, Rachel; Hart, Prue; Gorman, Shelley; Gies, Peter; Sherriff, Jill; Swaminathan, Ashwin; Beilin, Lawrence; Mori, Trevor; King, Laura; Black, Lucinda; Marshall, Kushani; Xiang, Fan; Wyatt, Candy; King, Kerryn; Slevin, Terry; Pandeya, Nirmala; Lucas, Robyn.

    In: BMC Public Health, Vol. 15, No. 1, 115, 10.02.2015, p. 1-9.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function

    T2 - The Sun Exposure and Vitamin D Supplementation (SEDS) Study

    AU - Hartley, Mica

    AU - Hoare, Samuel

    AU - LITHANDER, Fiona

    AU - Neale, Rachel

    AU - Hart, Prue

    AU - Gorman, Shelley

    AU - Gies, Peter

    AU - Sherriff, Jill

    AU - Swaminathan, Ashwin

    AU - Beilin, Lawrence

    AU - Mori, Trevor

    AU - King, Laura

    AU - Black, Lucinda

    AU - Marshall, Kushani

    AU - Xiang, Fan

    AU - Wyatt, Candy

    AU - King, Kerryn

    AU - Slevin, Terry

    AU - Pandeya, Nirmala

    AU - Lucas, Robyn

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    N2 - Background: Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. Methods/Design: The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. Discussion: This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention.

    AB - Background: Adults living in the sunny Australian climate are at high risk of skin cancer, but vitamin D deficiency (defined here as a serum 25-hydroxyvitamin D (25(OH)D) concentration of less than 50 nmol/L) is also common. Vitamin D deficiency may be a risk factor for a range of diseases. However, the optimal strategies to achieve and maintain vitamin D adequacy (sun exposure, vitamin D supplementation or both), and whether sun exposure itself has benefits over and above initiating synthesis of vitamin D, remain unclear. The Sun Exposure and Vitamin D Supplementation (SEDS) Study aims to compare the effectiveness of sun exposure and vitamin D supplementation for the management of vitamin D insufficiency, and to test whether these management strategies differentially affect markers of immune and cardio-metabolic function. Methods/Design: The SEDS Study is a multi-centre, randomised controlled trial of two different daily doses of vitamin D supplementation, and placebo, in conjunction with guidance on two different patterns of sun exposure. Participants recruited from across Australia are aged 18-64 years and have a recent vitamin D test result showing a serum 25(OH)D level of 40-60 nmol/L. Discussion: This paper discusses the rationale behind the study design, and considers the challenges but necessity of data collection within a non-institutionalised adult population, in order to address the study aims. We also discuss the challenges of participant recruitment and retention, ongoing engagement of referring medical practitioners and address issues of compliance and participant retention.

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    KW - New Zealand/epidemiology

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    KW - Vitamins/administration & dosage

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