Comparison of 6-Month Outcomes of COVID-19 vs Non-COVID-19 Survivors of Critical Illness

COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group

doi:10.1164/rccm.202110-2335OC

Comparison of 6-Month Outcomes of COVID-19 vs Non-COVID-19 Survivors of Critical Illness

COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group

Physiotherapy

Research output: Contribution to journal › Other Journal Article › peer-review

53 Citations (Scopus)

81 Downloads (Pure)

Abstract

RATIONALE: The outcomes of survivors of critical illness due to COVID-19 compared to non-COVID are yet to be established.

OBJECTIVE: We aimed to compare new disability at 6-months in mechanically ventilated patients admitted to Australian intensive care units (ICUs) with COVID-19 compared to non-COVID-19.

METHODS: We included COVID-19 and non-COVID-19 critically ill patients from two prospective observational studies. Patients were eligible if they were adult (age ≥18 years) with over 24 hours of mechanical ventilation.

MEASUREMENTS: Demographic, intervention and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0.

MAIN RESULTS: Between 6 March 2020 and 21 April 2021, 120 critically ill patients with COVID-19 and between August 2017 and January 2019, 199 critically ill patients without COVID-19 fulfilled the inclusion criteria. Patients with COVID-19 were older (62 (55-71) vs 58 (44-69), p=0.019) with a lower APACHE II (17 (13-20) vs 19 (15-23), p=0.011). While duration of ventilation was longer in patients with COVID-19 compared to without COVID-19 (12 days (5-19) vs 4.8 (2.3-8.8), p <0.001), 180-day mortality was similar between the groups (39/120 (32.5%) vs 70/199 (35.2%), p=0.715). The incidence of death or new disability at 180 days was similar (58/93 (62.4%) versus 99/150 (66/0%), p=0.583).

CONCLUSION: At 6-months there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared to non-COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Original language	English
Pages (from-to)	1159-1168
Number of pages	10
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	205
Issue number	10
DOIs	https://doi.org/10.1164/rccm.202110-2335OC
Publication status	Published - 15 May 2022

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@article{4de3b96d352544fbb4a2dc21a01f490e,

title = "Comparison of 6-Month Outcomes of COVID-19 vs Non-COVID-19 Survivors of Critical Illness",

abstract = "RATIONALE: The outcomes of survivors of critical illness due to COVID-19 compared to non-COVID are yet to be established.OBJECTIVE: We aimed to compare new disability at 6-months in mechanically ventilated patients admitted to Australian intensive care units (ICUs) with COVID-19 compared to non-COVID-19.METHODS: We included COVID-19 and non-COVID-19 critically ill patients from two prospective observational studies. Patients were eligible if they were adult (age ≥18 years) with over 24 hours of mechanical ventilation.MEASUREMENTS: Demographic, intervention and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0.MAIN RESULTS: Between 6 March 2020 and 21 April 2021, 120 critically ill patients with COVID-19 and between August 2017 and January 2019, 199 critically ill patients without COVID-19 fulfilled the inclusion criteria. Patients with COVID-19 were older (62 (55-71) vs 58 (44-69), p=0.019) with a lower APACHE II (17 (13-20) vs 19 (15-23), p=0.011). While duration of ventilation was longer in patients with COVID-19 compared to without COVID-19 (12 days (5-19) vs 4.8 (2.3-8.8), p <0.001), 180-day mortality was similar between the groups (39/120 (32.5%) vs 70/199 (35.2%), p=0.715). The incidence of death or new disability at 180 days was similar (58/93 (62.4%) versus 99/150 (66/0%), p=0.583).CONCLUSION: At 6-months there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared to non-COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

keywords = "critical care, long COVID, long-term outcomes, recovery, SARS-CoV-2",

author = "{COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group} and Hodgson, {Carol L} and Higgins, {Alisa M} and Bailey, {Michael J} and Mather, {Anne M} and Lisa Beach and Rinaldo Bellomo and Bernie Bissett and Boden, {Ianthe J} and Scott Bradley and Aidan Burrell and Cooper, {D James} and Fulcher, {Bentley J} and Haines, {Kimberley J} and Hodgson, {Isabelle T} and Jack Hopkins and Jones, {Alice Y M} and Stuart Lane and Drew Lawrence and {van der Lee}, Lisa and Jennifer Liacos and Linke, {Natalie J} and {Marques Gomes}, Lonni and Marc Nickels and George Ntoumenopoulos and Myles, {Paul S} and Shane Patman and Michelle Paton and Gemma Pound and Sumeet Rai and Alana Rix and Rollinson, {Thomas C} and Tipping, {Claire J} and Peter Thomas and Tony Trapani and Udy, {Andrew A} and Christina Whitehead and Shannah Anderson and {Serpa Neto}, Ary",

note = "Funding Information: Acknowledgment: This work was completed with thanks to the patients, families, and all staff who contributed to the care of COVID-19 patients in Australian ICUs and the SPRINT-SARI (Short Period Incidence Study of Severe Acute Respiratory Infection) Australia management committee, investigators, and research coordinators. SPRINT-SARI Australia is supported by the Department of Health, Commonwealth of Australia (Standing Deed SON60002733). Funding Information: Supported by a National Health and Medical Research Council Australia Translational Project grant (the PREDICT study [Predicting the Outcome of Critically Ill Patients]) and National Health and Medical Research Council Australia Investigator grant GNT1173271 (C.L.H.). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. Publisher Copyright: Copyright {\textcopyright} 2022 by the American Thoracic Society",

year = "2022",

month = may,

day = "15",

doi = "10.1164/rccm.202110-2335OC",

language = "English",

volume = "205",

pages = "1159--1168",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "10",

}

TY - JOUR

T1 - Comparison of 6-Month Outcomes of COVID-19 vs Non-COVID-19 Survivors of Critical Illness

AU - COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group

AU - Hodgson, Carol L

AU - Higgins, Alisa M

AU - Bailey, Michael J

AU - Mather, Anne M

AU - Beach, Lisa

AU - Bellomo, Rinaldo

AU - Bissett, Bernie

AU - Boden, Ianthe J

AU - Bradley, Scott

AU - Burrell, Aidan

AU - Cooper, D James

AU - Fulcher, Bentley J

AU - Haines, Kimberley J

AU - Hodgson, Isabelle T

AU - Hopkins, Jack

AU - Jones, Alice Y M

AU - Lane, Stuart

AU - Lawrence, Drew

AU - van der Lee, Lisa

AU - Liacos, Jennifer

AU - Linke, Natalie J

AU - Marques Gomes, Lonni

AU - Nickels, Marc

AU - Ntoumenopoulos, George

AU - Myles, Paul S

AU - Patman, Shane

AU - Paton, Michelle

AU - Pound, Gemma

AU - Rai, Sumeet

AU - Rix, Alana

AU - Rollinson, Thomas C

AU - Tipping, Claire J

AU - Thomas, Peter

AU - Trapani, Tony

AU - Udy, Andrew A

AU - Whitehead, Christina

AU - Anderson, Shannah

AU - Serpa Neto, Ary

N1 - Funding Information: Acknowledgment: This work was completed with thanks to the patients, families, and all staff who contributed to the care of COVID-19 patients in Australian ICUs and the SPRINT-SARI (Short Period Incidence Study of Severe Acute Respiratory Infection) Australia management committee, investigators, and research coordinators. SPRINT-SARI Australia is supported by the Department of Health, Commonwealth of Australia (Standing Deed SON60002733). Funding Information: Supported by a National Health and Medical Research Council Australia Translational Project grant (the PREDICT study [Predicting the Outcome of Critically Ill Patients]) and National Health and Medical Research Council Australia Investigator grant GNT1173271 (C.L.H.). The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. Publisher Copyright: Copyright © 2022 by the American Thoracic Society

PY - 2022/5/15

Y1 - 2022/5/15

N2 - RATIONALE: The outcomes of survivors of critical illness due to COVID-19 compared to non-COVID are yet to be established.OBJECTIVE: We aimed to compare new disability at 6-months in mechanically ventilated patients admitted to Australian intensive care units (ICUs) with COVID-19 compared to non-COVID-19.METHODS: We included COVID-19 and non-COVID-19 critically ill patients from two prospective observational studies. Patients were eligible if they were adult (age ≥18 years) with over 24 hours of mechanical ventilation.MEASUREMENTS: Demographic, intervention and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0.MAIN RESULTS: Between 6 March 2020 and 21 April 2021, 120 critically ill patients with COVID-19 and between August 2017 and January 2019, 199 critically ill patients without COVID-19 fulfilled the inclusion criteria. Patients with COVID-19 were older (62 (55-71) vs 58 (44-69), p=0.019) with a lower APACHE II (17 (13-20) vs 19 (15-23), p=0.011). While duration of ventilation was longer in patients with COVID-19 compared to without COVID-19 (12 days (5-19) vs 4.8 (2.3-8.8), p <0.001), 180-day mortality was similar between the groups (39/120 (32.5%) vs 70/199 (35.2%), p=0.715). The incidence of death or new disability at 180 days was similar (58/93 (62.4%) versus 99/150 (66/0%), p=0.583).CONCLUSION: At 6-months there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared to non-COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

AB - RATIONALE: The outcomes of survivors of critical illness due to COVID-19 compared to non-COVID are yet to be established.OBJECTIVE: We aimed to compare new disability at 6-months in mechanically ventilated patients admitted to Australian intensive care units (ICUs) with COVID-19 compared to non-COVID-19.METHODS: We included COVID-19 and non-COVID-19 critically ill patients from two prospective observational studies. Patients were eligible if they were adult (age ≥18 years) with over 24 hours of mechanical ventilation.MEASUREMENTS: Demographic, intervention and hospital outcome data were obtained from electronic medical records. Survivors were contacted by telephone for functional outcomes with trained outcome assessors using the World Health Organization Disability Assessment Schedule 2.0.MAIN RESULTS: Between 6 March 2020 and 21 April 2021, 120 critically ill patients with COVID-19 and between August 2017 and January 2019, 199 critically ill patients without COVID-19 fulfilled the inclusion criteria. Patients with COVID-19 were older (62 (55-71) vs 58 (44-69), p=0.019) with a lower APACHE II (17 (13-20) vs 19 (15-23), p=0.011). While duration of ventilation was longer in patients with COVID-19 compared to without COVID-19 (12 days (5-19) vs 4.8 (2.3-8.8), p <0.001), 180-day mortality was similar between the groups (39/120 (32.5%) vs 70/199 (35.2%), p=0.715). The incidence of death or new disability at 180 days was similar (58/93 (62.4%) versus 99/150 (66/0%), p=0.583).CONCLUSION: At 6-months there was no difference in new disability for patients requiring mechanical ventilation for acute respiratory failure due to COVID-19 compared to non-COVID-19. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

KW - critical care

KW - long COVID

KW - long-term outcomes

KW - recovery

KW - SARS-CoV-2

UR - http://www.scopus.com/inward/record.url?scp=85130632826&partnerID=8YFLogxK

U2 - 10.1164/rccm.202110-2335OC

DO - 10.1164/rccm.202110-2335OC

M3 - Other Journal Article

C2 - 35258437

SN - 1073-449X

VL - 205

SP - 1159

EP - 1168

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 10

ER -

Comparison of 6-Month Outcomes of COVID-19 vs Non-COVID-19 Survivors of Critical Illness

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