Contraception Targets in Mammalian Ovarian Development

Eileen A. McLaughlin, Alexander P. Sobinoff

Research output: A Conference proceeding or a Chapter in BookChapter

5 Citations (Scopus)

Abstract

In the human ovary, early in pre-natal life, oocytes are surrounded by pre-granulosa follicular cells to form primordial follicles. These primordial oocytes remain dormant, often for decades, until recruited into the growing pool throughout a woman's adult reproductive years. Activation of follicle growth and subsequent development of growing oocytes in pre-antral follicles are major biological checkpoints that determine an individual females reproductive potential. In the past decade, great strides have been made in the elucidation of the molecular and cellular mechanisms underpinning maintenance of the quiescent primordial follicle pool and initiation and development of follicle growth. Gaining an in-depth knowledge of the intracellular signalling systems that control oocyte preservation and follicle activation has significant implications for improving female reproductive productivity and alleviating infertility. It also has application in domestic animal husbandry, feral animal population control and contraception in women.

Original languageEnglish
Title of host publicationFertility Control
EditorsUrsula-F. Habenicht, R. John Aitken
Place of PublicationBerlin
PublisherSpringer
Pages45-66
Number of pages22
ISBN (Electronic)9783642020629
ISBN (Print)9783642020612
DOIs
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume198
ISSN (Print)0171-2004

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  • Cite this

    McLaughlin, E. A., & Sobinoff, A. P. (2010). Contraception Targets in Mammalian Ovarian Development. In U-F. Habenicht, & R. J. Aitken (Eds.), Fertility Control (pp. 45-66). (Handbook of Experimental Pharmacology; Vol. 198). Springer. https://doi.org/10.1007/978-3-642-02062-9_4