Contraception Targets in Mammalian Ovarian Development

Eileen A. McLaughlin, Alexander P. Sobinoff

Research output: A Conference proceeding or a Chapter in BookChapter

5 Citations (Scopus)

Abstract

In the human ovary, early in pre-natal life, oocytes are surrounded by pre-granulosa follicular cells to form primordial follicles. These primordial oocytes remain dormant, often for decades, until recruited into the growing pool throughout a woman's adult reproductive years. Activation of follicle growth and subsequent development of growing oocytes in pre-antral follicles are major biological checkpoints that determine an individual females reproductive potential. In the past decade, great strides have been made in the elucidation of the molecular and cellular mechanisms underpinning maintenance of the quiescent primordial follicle pool and initiation and development of follicle growth. Gaining an in-depth knowledge of the intracellular signalling systems that control oocyte preservation and follicle activation has significant implications for improving female reproductive productivity and alleviating infertility. It also has application in domestic animal husbandry, feral animal population control and contraception in women.

Original languageEnglish
Title of host publicationFertility Control
EditorsUrsula-F. Habenicht, R. John Aitken
Place of PublicationBerlin
PublisherSpringer
Pages45-66
Number of pages22
ISBN (Electronic)9783642020629
ISBN (Print)9783642020612
DOIs
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume198
ISSN (Print)0171-2004

Fingerprint

Contraception
Oocytes
Animals
Chemical activation
Growth and Development
Productivity
Animal Husbandry
Control systems
Population Control
Granulosa Cells
Domestic Animals
Infertility
Ovary
Maintenance
Antral
feral

Cite this

McLaughlin, E. A., & Sobinoff, A. P. (2010). Contraception Targets in Mammalian Ovarian Development. In U-F. Habenicht, & R. J. Aitken (Eds.), Fertility Control (pp. 45-66). (Handbook of Experimental Pharmacology; Vol. 198). Berlin: Springer. https://doi.org/10.1007/978-3-642-02062-9_4
McLaughlin, Eileen A. ; Sobinoff, Alexander P. / Contraception Targets in Mammalian Ovarian Development. Fertility Control. editor / Ursula-F. Habenicht ; R. John Aitken. Berlin : Springer, 2010. pp. 45-66 (Handbook of Experimental Pharmacology).
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McLaughlin, EA & Sobinoff, AP 2010, Contraception Targets in Mammalian Ovarian Development. in U-F Habenicht & RJ Aitken (eds), Fertility Control. Handbook of Experimental Pharmacology, vol. 198, Springer, Berlin, pp. 45-66. https://doi.org/10.1007/978-3-642-02062-9_4

Contraception Targets in Mammalian Ovarian Development. / McLaughlin, Eileen A.; Sobinoff, Alexander P.

Fertility Control. ed. / Ursula-F. Habenicht; R. John Aitken. Berlin : Springer, 2010. p. 45-66 (Handbook of Experimental Pharmacology; Vol. 198).

Research output: A Conference proceeding or a Chapter in BookChapter

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McLaughlin EA, Sobinoff AP. Contraception Targets in Mammalian Ovarian Development. In Habenicht U-F, Aitken RJ, editors, Fertility Control. Berlin: Springer. 2010. p. 45-66. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-642-02062-9_4