Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children - the LOOK study

Dick TELFORD, Ross Cunningham, Jonathan Shaw, David Dunstan, Tony Lafferty, Graham Reynolds, Peter Hickman, Emma Southcott, Julia M. Potter, Paul Waring, Rohan Telford

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness and physical activity in children- the LOOK study.Background: Knowledge of individual changes in insulin resistance (IR) and longitudinal relationships of IR with lifestyle-associated factors are of important practical significance, but little longitudinal data exist in asymptomatic children. We aimed to determine (a) changes in the homeostatic model of insulin resistance (HOMA-IR) over a 2-yr period and (b) comparisons of longitudinal and cross-sectional relationships between HOMA-IR and lifestyle-related risk factors. Methods: Our subjects, 241 boys and 257 girls, were assessed at age 8.1 yr (SD 0.35) and again 2 yr later for fasting blood glucose and insulin, dual X-ray absorptiometry-assessed percentage of body fat (%BF), pedometer-assessed physical activity (PA), and cardio-respiratory fitness (CRF) by multistage running test.
Original languageEnglish
Pages (from-to)500-507
Number of pages8
JournalPediatric Diabetes
Volume10
Issue number8
DOIs
Publication statusPublished - 2009
Externally publishedYes

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