Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness and physical activity in children- the LOOK study.Background: Knowledge of individual changes in insulin resistance (IR) and longitudinal relationships of IR with lifestyle-associated factors are of important practical significance, but little longitudinal data exist in asymptomatic children. We aimed to determine (a) changes in the homeostatic model of insulin resistance (HOMA-IR) over a 2-yr period and (b) comparisons of longitudinal and cross-sectional relationships between HOMA-IR and lifestyle-related risk factors. Methods: Our subjects, 241 boys and 257 girls, were assessed at age 8.1 yr (SD 0.35) and again 2 yr later for fasting blood glucose and insulin, dual X-ray absorptiometry-assessed percentage of body fat (%BF), pedometer-assessed physical activity (PA), and cardio-respiratory fitness (CRF) by multistage running test.
TELFORD, D., Cunningham, R., Shaw, J., Dunstan, D., Lafferty, T., Reynolds, G., Hickman, P., Southcott, E., Potter, J. M., Waring, P., & Telford, R. (2009). Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children - the LOOK study. Pediatric Diabetes, 10(8), 500-507. https://doi.org/10.1111/j.1399-5448.2009.00513.x