Control of interleukin-2 gene transcription: A paradigm for inducible, tissue-specific gene expression

Karen Bunting, Jun Wang, Frances Shannon

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Interleukin-2 (IL-2) is a key cytokine that controls immune cell function, in particular the adaptive arm of the immune system, through its ability to control the clonal expansion and homeostasis of peripheral T cells. IL-2 is produced almost exclusively by T cells in response to antigenic stimulation and thus provides an excellent example of a cell-specific inducible gene. The mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed
Original languageEnglish
Pages (from-to)105-145
Number of pages41
JournalVitamins and Hormones
Volume74
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Interleukin-2
Gene Expression
Genes
T-Lymphocytes
Immune System
Homeostasis
Cytokines

Cite this

Bunting, Karen ; Wang, Jun ; Shannon, Frances. / Control of interleukin-2 gene transcription: A paradigm for inducible, tissue-specific gene expression. In: Vitamins and Hormones. 2006 ; Vol. 74. pp. 105-145.
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Control of interleukin-2 gene transcription: A paradigm for inducible, tissue-specific gene expression. / Bunting, Karen; Wang, Jun; Shannon, Frances.

In: Vitamins and Hormones, Vol. 74, 2006, p. 105-145.

Research output: Contribution to journalArticle

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