Control of interleukin-2 gene transcription: A paradigm for inducible, tissue-specific gene expression

Karen Bunting, Jun Wang, Frances Shannon

Research output: Contribution to journalArticle

18 Citations (Scopus)


Interleukin-2 (IL-2) is a key cytokine that controls immune cell function, in particular the adaptive arm of the immune system, through its ability to control the clonal expansion and homeostasis of peripheral T cells. IL-2 is produced almost exclusively by T cells in response to antigenic stimulation and thus provides an excellent example of a cell-specific inducible gene. The mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed
Original languageEnglish
Pages (from-to)105-145
Number of pages41
JournalVitamins and Hormones
Publication statusPublished - 2006
Externally publishedYes


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