Controlling the swimming speed of human sperm by varying the incubation temperature and its effect on cervical mucus penetration

W. C L FORD, F. A. PONTING, E. A. MCLAUGHLIN, J. M. REES, M. G R HULL

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The objective of the present experiments was to study the effect of sperm velocity as a single variable on the ability of sperm to penetrate cervical mucus in a modified Kremer test. Sperm incubated at 13, 22 and 37d̀C exhibited progressive velocities of 25±1.7, 40±2.1 μ sec‐1 (mean±SEM, n = 6) respectively, but the percentage of progressively motile sperm, their lateral head displacement and the viscoelastic properties of cervical mucus remained comparatively unchanged over this temperature range. The number of sperm which penetrated the mucus and the percentage of successful collisions were correlated strongly with the average velocity of the sperm population (r = 0.82 and r = 0.72 respectively). It is concluded that sperm velocity has an important influence on the penetration of cervical mucus because it governs the frequency of collisions with the mucus interface and is determined by the thrust generated by the flagellum which also determines the ability of the sperm to traverse the mucus interface.

Original languageEnglish
Pages (from-to)127-134
Number of pages8
JournalInternational Journal of Andrology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1992
Externally publishedYes

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Cervix Mucus
Spermatozoa
Temperature
Mucus
Sperm Count
Flagella

Cite this

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title = "Controlling the swimming speed of human sperm by varying the incubation temperature and its effect on cervical mucus penetration",
abstract = "The objective of the present experiments was to study the effect of sperm velocity as a single variable on the ability of sperm to penetrate cervical mucus in a modified Kremer test. Sperm incubated at 13, 22 and 37d̀C exhibited progressive velocities of 25±1.7, 40±2.1 μ sec‐1 (mean±SEM, n = 6) respectively, but the percentage of progressively motile sperm, their lateral head displacement and the viscoelastic properties of cervical mucus remained comparatively unchanged over this temperature range. The number of sperm which penetrated the mucus and the percentage of successful collisions were correlated strongly with the average velocity of the sperm population (r = 0.82 and r = 0.72 respectively). It is concluded that sperm velocity has an important influence on the penetration of cervical mucus because it governs the frequency of collisions with the mucus interface and is determined by the thrust generated by the flagellum which also determines the ability of the sperm to traverse the mucus interface.",
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Controlling the swimming speed of human sperm by varying the incubation temperature and its effect on cervical mucus penetration. / FORD, W. C L; PONTING, F. A.; MCLAUGHLIN, E. A.; REES, J. M.; HULL, M. G R.

In: International Journal of Andrology, Vol. 15, No. 2, 04.1992, p. 127-134.

Research output: Contribution to journalArticle

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