Core skeletal muscle ryanodine receptor calcium release complex

Angela F. Dulhunty, Lan Wei-LaPierre, Marco Casarotto, Nicole BEARD

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The core skeletal muscle ryanodine receptor (RyR1) calcium release complex extends through three compartments of the muscle fibre, linking the extracellular environment through the cytoplasmic junctional gap to the lumen of the internal sarcoplasmic reticulum (SR) calcium store. The protein complex is essential for skeletal excitation-contraction (EC)-coupling and skeletal muscle function. Its importance is highlighted by perinatal death if any one of the EC-coupling components are missing and by myopathies associated with mutation of any of the proteins. The proteins essential for EC-coupling include the DHPR a1S subunit in the transverse tubule membrane, the DHPR ß1a subunit in the cytosol and the RyR1 ion channel in the SR membrane. The other core proteins are triadin and junctin and calsequestrin, associated mainly with SR. These SR proteins are not essential for survival but exert structural and functional influences that modify the gain of EC-coupling and maintain normal muscle function. This review summarises our current knowledge of the individual protein/protein interactions within the core complex and their overall contribution to EC-coupling. We highlight significant areas that provide a continuing challenge for the field. Additional important components of the Ca2+ release complex, such as FKBP12, calmodulin, S100A1 and Stac3 are identified and reviewed elsewhere.
Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalClinical and Experimental Pharmacology and Physiology
Volume44
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

Ryanodine Receptor Calcium Release Channel
Excitation Contraction Coupling
Skeletal Muscle
Sarcoplasmic Reticulum
Proteins
Tacrolimus Binding Protein 1A
Calsequestrin
Calcium
Muscles
Membranes
Muscular Diseases
Calmodulin
Ion Channels
Cytosol
Mutation

Cite this

Dulhunty, Angela F. ; Wei-LaPierre, Lan ; Casarotto, Marco ; BEARD, Nicole. / Core skeletal muscle ryanodine receptor calcium release complex. In: Clinical and Experimental Pharmacology and Physiology. 2017 ; Vol. 44, No. 1. pp. 3-12.
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Core skeletal muscle ryanodine receptor calcium release complex. / Dulhunty, Angela F.; Wei-LaPierre, Lan; Casarotto, Marco; BEARD, Nicole.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 44, No. 1, 2017, p. 3-12.

Research output: Contribution to journalArticle

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