TY - JOUR
T1 - COVID-19 in the elderly people and advances in vaccination approaches
AU - Dhama, Kuldeep
AU - Patel, Shailesh Kumar
AU - Natesan, Senthilkumar
AU - Vora, Kranti Suresh
AU - Yatoo, Mohd Iqbal
AU - Tiwari, Ruchi
AU - Saxena, Shailendra K.
AU - Singh, Karam Pal
AU - Singh, Rajendra
AU - Malik, Yashpal Singh
N1 - Funding Information:
This compilation is a review article written by its authors and required no substantial funding to be stated. All the authors acknowledge and thank their respective Institutes and Universities.
Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of millions of infections and over one million deaths. SARS-CoV-2 infection affects all age groups; however, those over 60 years old are affected more severely. Moreover, pre-existing co-morbidities result in higher COVID-19-associated mortality in the geriatric population. This article highlights the associated risk factors of SARS-CoV-2 infection in older people and progress in developing COVID-19 vaccines, especially for efficient vaccination of the older population. There is also a summary of immunomodulatory and immunotherapeutic approaches to ameliorate the outcome of COVID-19 in older individuals.
AB - The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of millions of infections and over one million deaths. SARS-CoV-2 infection affects all age groups; however, those over 60 years old are affected more severely. Moreover, pre-existing co-morbidities result in higher COVID-19-associated mortality in the geriatric population. This article highlights the associated risk factors of SARS-CoV-2 infection in older people and progress in developing COVID-19 vaccines, especially for efficient vaccination of the older population. There is also a summary of immunomodulatory and immunotherapeutic approaches to ameliorate the outcome of COVID-19 in older individuals.
KW - SARS-CoV-2
KW - covid-19
KW - elderly people
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=85097145596&partnerID=8YFLogxK
U2 - 10.1080/21645515.2020.1842683
DO - 10.1080/21645515.2020.1842683
M3 - Comment/debate
SN - 2164-5515
VL - 16
SP - 2938
EP - 2943
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
IS - 12
ER -
