Cross-sectional study of high-sensitivity cardiac troponins T and I in a hospital and community outpatient setting

Julia Potter, Aaron Simpson, Jennifer Kerrigan, Emma Southcott, Marie Salib, Gus KOERBIN, Peter Hickman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives Cardiac troponins are specific for the heart, but not for the acute coronary syndrome. We wanted to assess how common elevated cardiac troponin concentrations were, in a population with significant non-cardiac disease. Design Methods We measured both hs-cTnT and hs-cTnI on all samples submitted to the laboratory during one 24 h period, and assessed the magnitude of the cTn concentration with the location and severity of disease of the patient. Results Community patients and patients from the maternity ward had the lowest cTn concentrations with results above the 99th percentile being only 0–2% of the total. As expected, the highest proportion of results > 99th percentile came from Coronary Care and Intensive Care. However, substantial numbers of persons on Medical and Surgical wards, without a primary diagnosis of cardiac disease, also had cTn > 99th percentile. Particularly for cTnT, there was a highly significant odds ratio predicting mortality when results above and below the 99th percentile were compared. Conclusions Significant illnesses apart from the acute coronary syndrome are important causes of a rise in cTn to above the 99th percentile, and appear to reflect the total body burden of disease. Even when the high hs-cTn concentration is not due to the acute coronary syndrome, there is a significant association with all-cause mortality.
Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalClinical Biochemistry
Volume50
Issue number3
DOIs
Publication statusPublished - 2017

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Troponin T
Troponin I
Acute Coronary Syndrome
Troponin
Outpatients
Cross-Sectional Studies
Body Burden
Mortality
Critical Care
Heart Diseases
Odds Ratio
Population

Cite this

Potter, Julia ; Simpson, Aaron ; Kerrigan, Jennifer ; Southcott, Emma ; Salib, Marie ; KOERBIN, Gus ; Hickman, Peter. / Cross-sectional study of high-sensitivity cardiac troponins T and I in a hospital and community outpatient setting. In: Clinical Biochemistry. 2017 ; Vol. 50, No. 3. pp. 105-109.
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abstract = "Objectives Cardiac troponins are specific for the heart, but not for the acute coronary syndrome. We wanted to assess how common elevated cardiac troponin concentrations were, in a population with significant non-cardiac disease. Design Methods We measured both hs-cTnT and hs-cTnI on all samples submitted to the laboratory during one 24 h period, and assessed the magnitude of the cTn concentration with the location and severity of disease of the patient. Results Community patients and patients from the maternity ward had the lowest cTn concentrations with results above the 99th percentile being only 0–2{\%} of the total. As expected, the highest proportion of results > 99th percentile came from Coronary Care and Intensive Care. However, substantial numbers of persons on Medical and Surgical wards, without a primary diagnosis of cardiac disease, also had cTn > 99th percentile. Particularly for cTnT, there was a highly significant odds ratio predicting mortality when results above and below the 99th percentile were compared. Conclusions Significant illnesses apart from the acute coronary syndrome are important causes of a rise in cTn to above the 99th percentile, and appear to reflect the total body burden of disease. Even when the high hs-cTn concentration is not due to the acute coronary syndrome, there is a significant association with all-cause mortality.",
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Potter, J, Simpson, A, Kerrigan, J, Southcott, E, Salib, M, KOERBIN, G & Hickman, P 2017, 'Cross-sectional study of high-sensitivity cardiac troponins T and I in a hospital and community outpatient setting', Clinical Biochemistry, vol. 50, no. 3, pp. 105-109. https://doi.org/10.1016/j.clinbiochem.2016.10.011

Cross-sectional study of high-sensitivity cardiac troponins T and I in a hospital and community outpatient setting. / Potter, Julia; Simpson, Aaron; Kerrigan, Jennifer; Southcott, Emma; Salib, Marie; KOERBIN, Gus; Hickman, Peter.

In: Clinical Biochemistry, Vol. 50, No. 3, 2017, p. 105-109.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cross-sectional study of high-sensitivity cardiac troponins T and I in a hospital and community outpatient setting

AU - Potter, Julia

AU - Simpson, Aaron

AU - Kerrigan, Jennifer

AU - Southcott, Emma

AU - Salib, Marie

AU - KOERBIN, Gus

AU - Hickman, Peter

PY - 2017

Y1 - 2017

N2 - Objectives Cardiac troponins are specific for the heart, but not for the acute coronary syndrome. We wanted to assess how common elevated cardiac troponin concentrations were, in a population with significant non-cardiac disease. Design Methods We measured both hs-cTnT and hs-cTnI on all samples submitted to the laboratory during one 24 h period, and assessed the magnitude of the cTn concentration with the location and severity of disease of the patient. Results Community patients and patients from the maternity ward had the lowest cTn concentrations with results above the 99th percentile being only 0–2% of the total. As expected, the highest proportion of results > 99th percentile came from Coronary Care and Intensive Care. However, substantial numbers of persons on Medical and Surgical wards, without a primary diagnosis of cardiac disease, also had cTn > 99th percentile. Particularly for cTnT, there was a highly significant odds ratio predicting mortality when results above and below the 99th percentile were compared. Conclusions Significant illnesses apart from the acute coronary syndrome are important causes of a rise in cTn to above the 99th percentile, and appear to reflect the total body burden of disease. Even when the high hs-cTn concentration is not due to the acute coronary syndrome, there is a significant association with all-cause mortality.

AB - Objectives Cardiac troponins are specific for the heart, but not for the acute coronary syndrome. We wanted to assess how common elevated cardiac troponin concentrations were, in a population with significant non-cardiac disease. Design Methods We measured both hs-cTnT and hs-cTnI on all samples submitted to the laboratory during one 24 h period, and assessed the magnitude of the cTn concentration with the location and severity of disease of the patient. Results Community patients and patients from the maternity ward had the lowest cTn concentrations with results above the 99th percentile being only 0–2% of the total. As expected, the highest proportion of results > 99th percentile came from Coronary Care and Intensive Care. However, substantial numbers of persons on Medical and Surgical wards, without a primary diagnosis of cardiac disease, also had cTn > 99th percentile. Particularly for cTnT, there was a highly significant odds ratio predicting mortality when results above and below the 99th percentile were compared. Conclusions Significant illnesses apart from the acute coronary syndrome are important causes of a rise in cTn to above the 99th percentile, and appear to reflect the total body burden of disease. Even when the high hs-cTn concentration is not due to the acute coronary syndrome, there is a significant association with all-cause mortality.

KW - 99th percentile

KW - Acute coronary syndrome

KW - Cardiac troponin

KW - Non-cardiac illness

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U2 - 10.1016/j.clinbiochem.2016.10.011

DO - 10.1016/j.clinbiochem.2016.10.011

M3 - Article

VL - 50

SP - 105

EP - 109

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

IS - 3

ER -