@article{dc36e73d90474bcb9a3443f0207cd552,
title = "Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals",
abstract = "Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.",
keywords = "Daptomycin, Enantioselective, Monoliths, Nano-HPLC",
author = "Ali Fouad and Marzouk, {Adel A.} and Shaykoon, {Montaser Sh A.} and Ibrahim, {Samy M.} and El-Adl, {Sobhy M.} and Ashraf Ghanem",
note = "Funding Information: Funding: This research was supported, in part, by Al-Azhar University in Egypt and University of Canberra in Australia. Funding to A. Fouad was supported by the Cultural Affairs and Missions Sector Ministry of Higher Education, Egypt. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jun,
doi = "10.3390/molecules26123527",
language = "English",
volume = "26",
pages = "1--15",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}