Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals

Ali Fouad, Adel A. Marzouk, Montaser Sh A. Shaykoon, Samy M. Ibrahim, Sobhy M. El-Adl, Ashraf Ghanem

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Abstract

Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.

Original languageEnglish
Article number3527
Pages (from-to)1-15
Number of pages15
JournalMolecules
Volume26
Issue number12
DOIs
Publication statusPublished - Jun 2021

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