Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals

Ali Fouad; Adel A. Marzouk; Montaser Sh A. Shaykoon; Samy M. Ibrahim; Sobhy M. El-Adl; Ashraf Ghanem

doi:10.3390/molecules26123527

Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals

Ali Fouad
, Adel A. Marzouk
, Montaser Sh A. Shaykoon
, Samy M. Ibrahim
, Sobhy M. El-Adl
, Ashraf Ghanem

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

119 Downloads (Pure)

Abstract

Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.

Original language	English
Article number	3527
Pages (from-to)	1-15
Number of pages	15
Journal	Molecules
Volume	26
Issue number	12
DOIs	https://doi.org/10.3390/molecules26123527
Publication status	Published - Jun 2021

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Fouad, A., Marzouk, A. A., Shaykoon, M. S. A., Ibrahim, S. M., El-Adl, S. M., & Ghanem, A. (2021). Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals. Molecules, 26(12), 1-15. Article 3527. https://doi.org/10.3390/molecules26123527

Fouad, Ali ; Marzouk, Adel A. ; Shaykoon, Montaser Sh A. et al. / Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals : A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals. In: Molecules. 2021 ; Vol. 26, No. 12. pp. 1-15.

@article{dc36e73d90474bcb9a3443f0207cd552,

title = "Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals",

abstract = "Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.",

keywords = "Daptomycin, Enantioselective, Monoliths, Nano-HPLC",

author = "Ali Fouad and Marzouk, \{Adel A.\} and Shaykoon, \{Montaser Sh A.\} and Ibrahim, \{Samy M.\} and El-Adl, \{Sobhy M.\} and Ashraf Ghanem",

note = "Funding Information: Funding: This research was supported, in part, by Al-Azhar University in Egypt and University of Canberra in Australia. Funding to A. Fouad was supported by the Cultural Affairs and Missions Sector Ministry of Higher Education, Egypt. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

doi = "10.3390/molecules26123527",

language = "English",

volume = "26",

pages = "1--15",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

Fouad, A, Marzouk, AA, Shaykoon, MSA, Ibrahim, SM, El-Adl, SM & Ghanem, A 2021, 'Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals', Molecules, vol. 26, no. 12, 3527, pp. 1-15. https://doi.org/10.3390/molecules26123527

Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals. / Fouad, Ali; Marzouk, Adel A.; Shaykoon, Montaser Sh A. et al.
In: Molecules, Vol. 26, No. 12, 3527, 06.2021, p. 1-15.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals

T2 - A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals

AU - Fouad, Ali

AU - Marzouk, Adel A.

AU - Shaykoon, Montaser Sh A.

AU - Ibrahim, Samy M.

AU - El-Adl, Sobhy M.

AU - Ghanem, Ashraf

N1 - Funding Information: Funding: This research was supported, in part, by Al-Azhar University in Egypt and University of Canberra in Australia. Funding to A. Fouad was supported by the Cultural Affairs and Missions Sector Ministry of Higher Education, Egypt. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/6

Y1 - 2021/6

N2 - Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.

AB - Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.

KW - Daptomycin

KW - Enantioselective

KW - Monoliths

KW - Nano-HPLC

UR - https://www.scopus.com/pages/publications/85108380311

U2 - 10.3390/molecules26123527

DO - 10.3390/molecules26123527

M3 - Article

C2 - 34207780

AN - SCOPUS:85108380311

SN - 1420-3049

VL - 26

SP - 1

EP - 15

JO - Molecules

JF - Molecules

IS - 12

M1 - 3527

ER -

Fouad A, Marzouk AA, Shaykoon MSA, Ibrahim SM, El-Adl SM, Ghanem A. Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals: A novel macrocyclic antibiotic as a chiral selector in an organic polymer monolithic capillary for the enantioselective analysis of a set of pharmaceuticals. Molecules. 2021 Jun;26(12):1-15. 3527. doi: 10.3390/molecules26123527

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