Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis

Tomasz Cudejko, Martin van der Esch, Josien C. van den Noort, Judith J.M. Rijnhart, Marike van der Leeden, Leo D. Roorda, Willem Lems, Gordon Waddington, Jaap Harlaar, Joost Dekker

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Abstract

Objective: To evaluate whether improvement of proprioception, pain, or dynamic knee instability mediates the effect of wearing a soft knee brace on activity limitations in patients with knee osteoarthritis (OA). Methods: We conducted an analysis of data for 44 patients with knee OA who were enrolled in a laboratory-based trial evaluating the effect of wearing a commercially available soft knee brace. Activity limitations were assessed with the 10-meter walk test and the Get Up and Go test. Knee joint proprioception was assessed by an active joint position sense test; pain was assessed on a numeric rating scale (NRS) (range 0–10); pressure pain threshold (PPT) was assessed with a hand-held pressure algometer; dynamic knee instability was expressed by the perturbation response, i.e., a measure reflecting a deviation in mean knee varus–valgus angle after a controlled mechanical perturbation on a treadmill, with respect to level walking. Mediation analysis was conducted using the product of coefficients approach. Confidence intervals were calculated with a bootstrap procedure. Results: A decrease in pain (scored on an NRS) and a decrease in dynamic knee instability mediated the effect of wearing a soft knee brace on the reduction of activity limitations (P < 0.05), while changes in proprioception and PPT did not mediate this effect (P > 0.05). Conclusion: This study shows that decreased pain and reduced dynamic knee instability are pathways by which wearing a soft knee brace decreases activity limitations in patients with knee OA.

Original languageEnglish
Pages (from-to)1036-1043
Number of pages8
JournalArthritis Care and Research
Volume71
Issue number8
DOIs
Publication statusPublished - Aug 2019

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Braces
Knee Osteoarthritis
Knee
Pain
Proprioception
Pressure
Pain Threshold
Knee Joint
Walking
Hand
Joints
Confidence Intervals

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Cudejko, Tomasz ; van der Esch, Martin ; van den Noort, Josien C. ; Rijnhart, Judith J.M. ; van der Leeden, Marike ; Roorda, Leo D. ; Lems, Willem ; Waddington, Gordon ; Harlaar, Jaap ; Dekker, Joost. / Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis. In: Arthritis Care and Research. 2019 ; Vol. 71, No. 8. pp. 1036-1043.
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title = "Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis",
abstract = "Objective: To evaluate whether improvement of proprioception, pain, or dynamic knee instability mediates the effect of wearing a soft knee brace on activity limitations in patients with knee osteoarthritis (OA). Methods: We conducted an analysis of data for 44 patients with knee OA who were enrolled in a laboratory-based trial evaluating the effect of wearing a commercially available soft knee brace. Activity limitations were assessed with the 10-meter walk test and the Get Up and Go test. Knee joint proprioception was assessed by an active joint position sense test; pain was assessed on a numeric rating scale (NRS) (range 0–10); pressure pain threshold (PPT) was assessed with a hand-held pressure algometer; dynamic knee instability was expressed by the perturbation response, i.e., a measure reflecting a deviation in mean knee varus–valgus angle after a controlled mechanical perturbation on a treadmill, with respect to level walking. Mediation analysis was conducted using the product of coefficients approach. Confidence intervals were calculated with a bootstrap procedure. Results: A decrease in pain (scored on an NRS) and a decrease in dynamic knee instability mediated the effect of wearing a soft knee brace on the reduction of activity limitations (P < 0.05), while changes in proprioception and PPT did not mediate this effect (P > 0.05). Conclusion: This study shows that decreased pain and reduced dynamic knee instability are pathways by which wearing a soft knee brace decreases activity limitations in patients with knee OA.",
author = "Tomasz Cudejko and {van der Esch}, Martin and {van den Noort}, {Josien C.} and Rijnhart, {Judith J.M.} and {van der Leeden}, Marike and Roorda, {Leo D.} and Willem Lems and Gordon Waddington and Jaap Harlaar and Joost Dekker",
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Cudejko, T, van der Esch, M, van den Noort, JC, Rijnhart, JJM, van der Leeden, M, Roorda, LD, Lems, W, Waddington, G, Harlaar, J & Dekker, J 2019, 'Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis', Arthritis Care and Research, vol. 71, no. 8, pp. 1036-1043. https://doi.org/10.1002/acr.23722

Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis. / Cudejko, Tomasz; van der Esch, Martin; van den Noort, Josien C.; Rijnhart, Judith J.M.; van der Leeden, Marike; Roorda, Leo D.; Lems, Willem; Waddington, Gordon; Harlaar, Jaap; Dekker, Joost.

In: Arthritis Care and Research, Vol. 71, No. 8, 08.2019, p. 1036-1043.

Research output: Contribution to journalArticle

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T1 - Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis

AU - Cudejko, Tomasz

AU - van der Esch, Martin

AU - van den Noort, Josien C.

AU - Rijnhart, Judith J.M.

AU - van der Leeden, Marike

AU - Roorda, Leo D.

AU - Lems, Willem

AU - Waddington, Gordon

AU - Harlaar, Jaap

AU - Dekker, Joost

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