Deep learning in gene expression modeling

Dinesh KUMAR, Dharmendra SHARMA

Research output: A Conference proceeding or a Chapter in BookChapter

Abstract

Developing computational intelligence algorithms for learning insights from data has been a growing intellectual challenge. Much advances have already been made through data mining but there is an increasing research focus on deep learning to exploit the massive improvement in computational power. This chapter presents recent advancements in deep learning research and identifies some remaining challenges as drawn from using deep learning in the application area of gene expression modelling. It highlights deep learning (DL) as a branch of Machine Learning (ML), the various models and theoretical foundations, its motivations as to why we need deep learning in the context of evolving Big Data, particularly in the area of gene expression level classification. We present a review, and strengths and weaknesses of various DL models and their computational power to specific to gene expression modeling. Deep learning models are efficient feature selectors and therefore work best in high dimension datasets. We present major research challenges in feature extraction and selection using different deep models. Our case studies are drawn from gene expression datasets. Hence we report some of the key formats of gene expression datasets used for deep learning. As ongoing research we will discuss the future prospects of deep learning for gene expression modelling.

Original languageEnglish
Title of host publicationHandbook of Deep Learning Applications
EditorsValentina Balas, Sanjiban Roy, Dharmendra Sharma, Pijush Samui
Place of PublicationCham, Switzerland
PublisherSpringer
Pages363-383
Number of pages21
Volume136
ISBN (Electronic)9783030114794
ISBN (Print)9783030114787
DOIs
Publication statusPublished - 2019

Publication series

NameSmart Innovation, Systems and Technologies
Volume136

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KUMAR, D., & SHARMA, D. (2019). Deep learning in gene expression modeling. In V. Balas, S. Roy, D. Sharma, & P. Samui (Eds.), Handbook of Deep Learning Applications (Vol. 136, pp. 363-383). (Smart Innovation, Systems and Technologies; Vol. 136). Cham, Switzerland: Springer. https://doi.org/10.1007/978-3-030-11479-4_17