Diagnostic value of 64-slice CT angiography in coronary artery disease

A systematic review

Zhonghua Sun, ChengHsun Lin, Robert Davidson, Chiauhuei Dong, Yunchan Liao

Research output: Contribution to journalReview article

123 Citations (Scopus)

Abstract

Purpose: To perform a systematic review of the diagnostic value of 64-multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography. Materials and methods: A search of PUBMED and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing 64-slice MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analysed at segment-, vessel- and patient-based assessment. Results: Fifteen studies met selection criteria and were included for analysis. Pooled sensitivity, specificity, positive predictive value and negative predictive value as well as 95% confidence interval (CI) were 97% (94 and 99%), 88% (79 and 97%), 94% (91 and 97%), and 95% (90 and 99%) for patient-based assessment; 92% (85 and 99%), 92% (85 and 99%), 78% (66 and 91%) and 98% (96 and 99%) for vessel-based assessment; 90% (85 and 94%), 96% (95 and 97%), 75%(68 and 82%) and 98% (98 and 99%) for segment-based assessment, respectively. No significant difference was found in the diagnostic accuracy of 64-slice CT in the detection of CAD when comparison was performed either among four main coronary arteries, or between proximal and middle or distal segments (p > 0.05). Conclusion: Our results showed that 64-slice CT angiography has a high-diagnostic value in the detection of CAD. Severe coronary artery calcification seems to be the major factor affecting the visualisation and assessment.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalEuropean Journal of Radiology
Volume67
Issue number1
DOIs
Publication statusPublished - 1 Jul 2008
Externally publishedYes

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Coronary Artery Disease
Coronary Angiography
Coronary Vessels
Literature
MEDLINE
Patient Selection
Databases
Confidence Intervals
Sensitivity and Specificity
Computed Tomography Angiography

Cite this

Sun, Zhonghua ; Lin, ChengHsun ; Davidson, Robert ; Dong, Chiauhuei ; Liao, Yunchan. / Diagnostic value of 64-slice CT angiography in coronary artery disease : A systematic review. In: European Journal of Radiology. 2008 ; Vol. 67, No. 1. pp. 78-84.
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abstract = "Purpose: To perform a systematic review of the diagnostic value of 64-multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography. Materials and methods: A search of PUBMED and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing 64-slice MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analysed at segment-, vessel- and patient-based assessment. Results: Fifteen studies met selection criteria and were included for analysis. Pooled sensitivity, specificity, positive predictive value and negative predictive value as well as 95{\%} confidence interval (CI) were 97{\%} (94 and 99{\%}), 88{\%} (79 and 97{\%}), 94{\%} (91 and 97{\%}), and 95{\%} (90 and 99{\%}) for patient-based assessment; 92{\%} (85 and 99{\%}), 92{\%} (85 and 99{\%}), 78{\%} (66 and 91{\%}) and 98{\%} (96 and 99{\%}) for vessel-based assessment; 90{\%} (85 and 94{\%}), 96{\%} (95 and 97{\%}), 75{\%}(68 and 82{\%}) and 98{\%} (98 and 99{\%}) for segment-based assessment, respectively. No significant difference was found in the diagnostic accuracy of 64-slice CT in the detection of CAD when comparison was performed either among four main coronary arteries, or between proximal and middle or distal segments (p > 0.05). Conclusion: Our results showed that 64-slice CT angiography has a high-diagnostic value in the detection of CAD. Severe coronary artery calcification seems to be the major factor affecting the visualisation and assessment.",
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Diagnostic value of 64-slice CT angiography in coronary artery disease : A systematic review. / Sun, Zhonghua; Lin, ChengHsun; Davidson, Robert; Dong, Chiauhuei; Liao, Yunchan.

In: European Journal of Radiology, Vol. 67, No. 1, 01.07.2008, p. 78-84.

Research output: Contribution to journalReview article

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T1 - Diagnostic value of 64-slice CT angiography in coronary artery disease

T2 - A systematic review

AU - Sun, Zhonghua

AU - Lin, ChengHsun

AU - Davidson, Robert

AU - Dong, Chiauhuei

AU - Liao, Yunchan

PY - 2008/7/1

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N2 - Purpose: To perform a systematic review of the diagnostic value of 64-multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography. Materials and methods: A search of PUBMED and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing 64-slice MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analysed at segment-, vessel- and patient-based assessment. Results: Fifteen studies met selection criteria and were included for analysis. Pooled sensitivity, specificity, positive predictive value and negative predictive value as well as 95% confidence interval (CI) were 97% (94 and 99%), 88% (79 and 97%), 94% (91 and 97%), and 95% (90 and 99%) for patient-based assessment; 92% (85 and 99%), 92% (85 and 99%), 78% (66 and 91%) and 98% (96 and 99%) for vessel-based assessment; 90% (85 and 94%), 96% (95 and 97%), 75%(68 and 82%) and 98% (98 and 99%) for segment-based assessment, respectively. No significant difference was found in the diagnostic accuracy of 64-slice CT in the detection of CAD when comparison was performed either among four main coronary arteries, or between proximal and middle or distal segments (p > 0.05). Conclusion: Our results showed that 64-slice CT angiography has a high-diagnostic value in the detection of CAD. Severe coronary artery calcification seems to be the major factor affecting the visualisation and assessment.

AB - Purpose: To perform a systematic review of the diagnostic value of 64-multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography. Materials and methods: A search of PUBMED and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing 64-slice MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analysed at segment-, vessel- and patient-based assessment. Results: Fifteen studies met selection criteria and were included for analysis. Pooled sensitivity, specificity, positive predictive value and negative predictive value as well as 95% confidence interval (CI) were 97% (94 and 99%), 88% (79 and 97%), 94% (91 and 97%), and 95% (90 and 99%) for patient-based assessment; 92% (85 and 99%), 92% (85 and 99%), 78% (66 and 91%) and 98% (96 and 99%) for vessel-based assessment; 90% (85 and 94%), 96% (95 and 97%), 75%(68 and 82%) and 98% (98 and 99%) for segment-based assessment, respectively. No significant difference was found in the diagnostic accuracy of 64-slice CT in the detection of CAD when comparison was performed either among four main coronary arteries, or between proximal and middle or distal segments (p > 0.05). Conclusion: Our results showed that 64-slice CT angiography has a high-diagnostic value in the detection of CAD. Severe coronary artery calcification seems to be the major factor affecting the visualisation and assessment.

KW - Coronary artery disease

KW - Diagnostic value

KW - Multislice CT

KW - Systematic review

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JF - Journal of Medical Imaging

SN - 0720-048X

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