Dietary patterns and breast cancer risk

A study in 2 cohorts

Chelsea Catsburg, Rhungsuk Kim, Victoria Kirsh, Colin SOSKOLNE, Nancy Kreiger, Thomas Rohan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Evidence for a role of dietary risk factors in the cause of breast cancer has been inconsistent. The evaluation of overall dietary patterns instead of foods in isolation may better reflect the nature of true dietary exposure in a population. Objective: We used 2 cohort studies to identify and confirm associations between dietary patterns and breast cancer risk. Design: Dietary patterns were derived by using a principal components factor analysis in 1097 breast cancer cases and an age-stratified subcohort of 3320 women sampled from 39,532 female participants in the Canadian Study of Diet, Lifestyle and Health (CSDLH). We conducted a confirmatory factor analysis in 49,410 subjects in the National Breast Screening Study (NBSS) in whom 3659 cases of incident breast cancer developed. Cox regression models were used to estimate HRs for the association between derived dietary factors and risk of breast cancer in both cohorts. Results: The following 3 dietary factors were identified from the CSDLH: healthy, ethnic, and meat and potatoes. In the CSDLH, the healthy dietary pattern was associated with reduced risk of breast cancer (HR for high compared with low quintiles: 0.73; 95% CI: 0.58, 0.91; P-trend = 0.001), and the meat and potatoes dietary pattern was associated with increased risk in postmenopausal women only (HR for high compared with low quintiles: 1.26; 95% CI: 0.92, 1.73; P-trend = 0.043). In the NBSS, the association between the meat and potatoes pattern and postmenopausal breast cancer risk was confirmed (HR: 1.31; 95% CI: 0.98, 1.76; P-trend = 0.043), but there was no association between the healthy pattern and risk of breast cancer. Conclusion: Adherence to a plant-based diet that limits red meat intake may be associated with reduced risk of breast cancer, particularly in postmenopausal women.
Original languageEnglish
Pages (from-to)817-823
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume101
Issue number4
DOIs
Publication statusPublished - 2015

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Breast Neoplasms
Solanum tuberosum
Meat
Diet
Statistical Factor Analysis
Life Style
Health
Breast
Principal Component Analysis
Proportional Hazards Models
Cohort Studies
Food
Population

Cite this

Catsburg, C., Kim, R., Kirsh, V., SOSKOLNE, C., Kreiger, N., & Rohan, T. (2015). Dietary patterns and breast cancer risk: A study in 2 cohorts. American Journal of Clinical Nutrition, 101(4), 817-823. https://doi.org/10.3945/ajcn.114.097659
Catsburg, Chelsea ; Kim, Rhungsuk ; Kirsh, Victoria ; SOSKOLNE, Colin ; Kreiger, Nancy ; Rohan, Thomas. / Dietary patterns and breast cancer risk : A study in 2 cohorts. In: American Journal of Clinical Nutrition. 2015 ; Vol. 101, No. 4. pp. 817-823.
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abstract = "Background: Evidence for a role of dietary risk factors in the cause of breast cancer has been inconsistent. The evaluation of overall dietary patterns instead of foods in isolation may better reflect the nature of true dietary exposure in a population. Objective: We used 2 cohort studies to identify and confirm associations between dietary patterns and breast cancer risk. Design: Dietary patterns were derived by using a principal components factor analysis in 1097 breast cancer cases and an age-stratified subcohort of 3320 women sampled from 39,532 female participants in the Canadian Study of Diet, Lifestyle and Health (CSDLH). We conducted a confirmatory factor analysis in 49,410 subjects in the National Breast Screening Study (NBSS) in whom 3659 cases of incident breast cancer developed. Cox regression models were used to estimate HRs for the association between derived dietary factors and risk of breast cancer in both cohorts. Results: The following 3 dietary factors were identified from the CSDLH: healthy, ethnic, and meat and potatoes. In the CSDLH, the healthy dietary pattern was associated with reduced risk of breast cancer (HR for high compared with low quintiles: 0.73; 95{\%} CI: 0.58, 0.91; P-trend = 0.001), and the meat and potatoes dietary pattern was associated with increased risk in postmenopausal women only (HR for high compared with low quintiles: 1.26; 95{\%} CI: 0.92, 1.73; P-trend = 0.043). In the NBSS, the association between the meat and potatoes pattern and postmenopausal breast cancer risk was confirmed (HR: 1.31; 95{\%} CI: 0.98, 1.76; P-trend = 0.043), but there was no association between the healthy pattern and risk of breast cancer. Conclusion: Adherence to a plant-based diet that limits red meat intake may be associated with reduced risk of breast cancer, particularly in postmenopausal women.",
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Catsburg, C, Kim, R, Kirsh, V, SOSKOLNE, C, Kreiger, N & Rohan, T 2015, 'Dietary patterns and breast cancer risk: A study in 2 cohorts', American Journal of Clinical Nutrition, vol. 101, no. 4, pp. 817-823. https://doi.org/10.3945/ajcn.114.097659

Dietary patterns and breast cancer risk : A study in 2 cohorts. / Catsburg, Chelsea; Kim, Rhungsuk; Kirsh, Victoria; SOSKOLNE, Colin; Kreiger, Nancy; Rohan, Thomas.

In: American Journal of Clinical Nutrition, Vol. 101, No. 4, 2015, p. 817-823.

Research output: Contribution to journalArticle

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T1 - Dietary patterns and breast cancer risk

T2 - A study in 2 cohorts

AU - Catsburg, Chelsea

AU - Kim, Rhungsuk

AU - Kirsh, Victoria

AU - SOSKOLNE, Colin

AU - Kreiger, Nancy

AU - Rohan, Thomas

PY - 2015

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AB - Background: Evidence for a role of dietary risk factors in the cause of breast cancer has been inconsistent. The evaluation of overall dietary patterns instead of foods in isolation may better reflect the nature of true dietary exposure in a population. Objective: We used 2 cohort studies to identify and confirm associations between dietary patterns and breast cancer risk. Design: Dietary patterns were derived by using a principal components factor analysis in 1097 breast cancer cases and an age-stratified subcohort of 3320 women sampled from 39,532 female participants in the Canadian Study of Diet, Lifestyle and Health (CSDLH). We conducted a confirmatory factor analysis in 49,410 subjects in the National Breast Screening Study (NBSS) in whom 3659 cases of incident breast cancer developed. Cox regression models were used to estimate HRs for the association between derived dietary factors and risk of breast cancer in both cohorts. Results: The following 3 dietary factors were identified from the CSDLH: healthy, ethnic, and meat and potatoes. In the CSDLH, the healthy dietary pattern was associated with reduced risk of breast cancer (HR for high compared with low quintiles: 0.73; 95% CI: 0.58, 0.91; P-trend = 0.001), and the meat and potatoes dietary pattern was associated with increased risk in postmenopausal women only (HR for high compared with low quintiles: 1.26; 95% CI: 0.92, 1.73; P-trend = 0.043). In the NBSS, the association between the meat and potatoes pattern and postmenopausal breast cancer risk was confirmed (HR: 1.31; 95% CI: 0.98, 1.76; P-trend = 0.043), but there was no association between the healthy pattern and risk of breast cancer. Conclusion: Adherence to a plant-based diet that limits red meat intake may be associated with reduced risk of breast cancer, particularly in postmenopausal women.

KW - Breast cancer

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KW - PCFA

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KW - dietary patterns

KW - breast cancer

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