Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon

Hyunjung Cho, Sam KOSARI, Billie Hunne, Brid Callaghan, Leni Rivera, David Bravo, John Furness

Research output: Contribution to journalArticle

39 Citations (Scopus)


This study has investigated the patterns of colocalisation of the conventional K cell marker, glucagon-like insulinotropic peptide (GIP), and the L cell markers, glucagon like peptide-1 (GLP-1) and peptide YY (PYY), in enteroendocrine cells (EEC) of the small intestine and colon of mouse and pig. All combinations of the hormones, 3 in a cell, 2 in a cell and 1 at a time, were encountered. In both species, the three most common EEC types contained (1) both GLP-1 and PYY but not GIP, (2) GLP-1 alone or (3) GIP plus GLP-1 without PYY. Few GIP plus PYY cells and rare cells containing all 3 hormones were encountered. Gradients of cell types occurred along the intestine. For example, in mouse, there were no PYY cells in the duodenum and few in the jejunum, but >50 % of labelled EEC in the distal ileum and colon were PYY immunoreactive. By contrast, over 40 % of EEC in the pig duodenum contained PYY, and most also contained either GLP-1 or GIP. The gradient in pig was less pronounced. It is concluded that the traditional classification of K and L cells requires revision, and that there are major inter-species differences in the patterns of colocalisation of hormones that have been used to characterise K and L cells
Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalCell and Tissue Research
Issue number2
Publication statusPublished - 2015
Externally publishedYes


Cite this