Differing cytokine responses by ethnic groups to a bout of exercise-induced muscle damage

A preliminary report

Dorota Starzak, Stuart SEMPLE, Lucile Smith, Andrew MCKUNE

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Strenuous exercise has been shown to alter immune and inflammatory responses potentially predisposing athletes to infection and injury. Ethnic disparities have been demonstrated in athletic performance and in the way individuals respond to exercise as well as in the predisposition towards certain diseases however, the information relating to immune and inflammatory responses to exercise between ethnic groups is still limited. The aim of this study was to investigate whether serum cytokine levels respond differently to eccentrically-biased exercise in African and Caucasian males. Methods: Seven black and 8 white males (18-22 years), active but untrained, participated in the study. Participants performed a 60-minute downhill run on a treadmill (gradient -13.5%) at a speed eliciting 75% of their VO2peak on a level grade. Venipunctures were performed before, immediately after and then at 3, 6, 9, 12, 24 hours, and 1, 2 and 3 weeks afterwards. The following serum cytokine concentrations were quantified using the Bio-Plex suspension array system: IL-4, IL-6, IL-10, IL-Ira, IL-12p70, IFNγ, IL-7, IL-8, MCP-1, MIP-1β, eotaxin, IP-10, IL-1β, TNFα, GM-CSF, G-CSF, FGF basic and VEGF. Results: Significant differences between the two groups were evident from 6 hours postexercise onwards with the African runners maintaining significantly higher relative cytokine concentrations. IL-6 serum concentrations of the African runners, for example, ranged from 8% to 55.1% higher than that of the Caucasian runners from 6 hours to 2 weeks postexercise (P<0.05). Conclusions: The study demonstrated that the cytokine response to a bout of downhill running differs between African and Caucasian runners indicating that ethnicity may play a role in exercise-induced immune and inflammatory responses.

Original languageEnglish
Pages (from-to)665-677
Number of pages13
JournalThe Journal of Sports Medicine and Physical Fitness
Volume56
Issue number6
Publication statusPublished - 2016

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Ethnic Groups
Exercise
Cytokines
Muscles
Interleukin-6
Chemokine CCL11
Serum
Athletic Performance
Interleukin-7
Phlebotomy
Granulocyte Colony-Stimulating Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-8
Interleukin-1
Running
Interleukin-4
Athletes
Interleukin-10
Vascular Endothelial Growth Factor A
Suspensions

Cite this

@article{66db6aaef1d043188b9309a24cc7e6a6,
title = "Differing cytokine responses by ethnic groups to a bout of exercise-induced muscle damage: A preliminary report",
abstract = "Background: Strenuous exercise has been shown to alter immune and inflammatory responses potentially predisposing athletes to infection and injury. Ethnic disparities have been demonstrated in athletic performance and in the way individuals respond to exercise as well as in the predisposition towards certain diseases however, the information relating to immune and inflammatory responses to exercise between ethnic groups is still limited. The aim of this study was to investigate whether serum cytokine levels respond differently to eccentrically-biased exercise in African and Caucasian males. Methods: Seven black and 8 white males (18-22 years), active but untrained, participated in the study. Participants performed a 60-minute downhill run on a treadmill (gradient -13.5{\%}) at a speed eliciting 75{\%} of their VO2peak on a level grade. Venipunctures were performed before, immediately after and then at 3, 6, 9, 12, 24 hours, and 1, 2 and 3 weeks afterwards. The following serum cytokine concentrations were quantified using the Bio-Plex suspension array system: IL-4, IL-6, IL-10, IL-Ira, IL-12p70, IFNγ, IL-7, IL-8, MCP-1, MIP-1β, eotaxin, IP-10, IL-1β, TNFα, GM-CSF, G-CSF, FGF basic and VEGF. Results: Significant differences between the two groups were evident from 6 hours postexercise onwards with the African runners maintaining significantly higher relative cytokine concentrations. IL-6 serum concentrations of the African runners, for example, ranged from 8{\%} to 55.1{\%} higher than that of the Caucasian runners from 6 hours to 2 weeks postexercise (P<0.05). Conclusions: The study demonstrated that the cytokine response to a bout of downhill running differs between African and Caucasian runners indicating that ethnicity may play a role in exercise-induced immune and inflammatory responses.",
keywords = "Cytokines, Ethnic groups, Exercise, Inflammation, Running",
author = "Dorota Starzak and Stuart SEMPLE and Lucile Smith and Andrew MCKUNE",
year = "2016",
language = "English",
volume = "56",
pages = "665--677",
journal = "Journal of Sports Medicine and Physical Fitness",
issn = "0022-4707",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "6",

}

TY - JOUR

T1 - Differing cytokine responses by ethnic groups to a bout of exercise-induced muscle damage

T2 - A preliminary report

AU - Starzak, Dorota

AU - SEMPLE, Stuart

AU - Smith, Lucile

AU - MCKUNE, Andrew

PY - 2016

Y1 - 2016

N2 - Background: Strenuous exercise has been shown to alter immune and inflammatory responses potentially predisposing athletes to infection and injury. Ethnic disparities have been demonstrated in athletic performance and in the way individuals respond to exercise as well as in the predisposition towards certain diseases however, the information relating to immune and inflammatory responses to exercise between ethnic groups is still limited. The aim of this study was to investigate whether serum cytokine levels respond differently to eccentrically-biased exercise in African and Caucasian males. Methods: Seven black and 8 white males (18-22 years), active but untrained, participated in the study. Participants performed a 60-minute downhill run on a treadmill (gradient -13.5%) at a speed eliciting 75% of their VO2peak on a level grade. Venipunctures were performed before, immediately after and then at 3, 6, 9, 12, 24 hours, and 1, 2 and 3 weeks afterwards. The following serum cytokine concentrations were quantified using the Bio-Plex suspension array system: IL-4, IL-6, IL-10, IL-Ira, IL-12p70, IFNγ, IL-7, IL-8, MCP-1, MIP-1β, eotaxin, IP-10, IL-1β, TNFα, GM-CSF, G-CSF, FGF basic and VEGF. Results: Significant differences between the two groups were evident from 6 hours postexercise onwards with the African runners maintaining significantly higher relative cytokine concentrations. IL-6 serum concentrations of the African runners, for example, ranged from 8% to 55.1% higher than that of the Caucasian runners from 6 hours to 2 weeks postexercise (P<0.05). Conclusions: The study demonstrated that the cytokine response to a bout of downhill running differs between African and Caucasian runners indicating that ethnicity may play a role in exercise-induced immune and inflammatory responses.

AB - Background: Strenuous exercise has been shown to alter immune and inflammatory responses potentially predisposing athletes to infection and injury. Ethnic disparities have been demonstrated in athletic performance and in the way individuals respond to exercise as well as in the predisposition towards certain diseases however, the information relating to immune and inflammatory responses to exercise between ethnic groups is still limited. The aim of this study was to investigate whether serum cytokine levels respond differently to eccentrically-biased exercise in African and Caucasian males. Methods: Seven black and 8 white males (18-22 years), active but untrained, participated in the study. Participants performed a 60-minute downhill run on a treadmill (gradient -13.5%) at a speed eliciting 75% of their VO2peak on a level grade. Venipunctures were performed before, immediately after and then at 3, 6, 9, 12, 24 hours, and 1, 2 and 3 weeks afterwards. The following serum cytokine concentrations were quantified using the Bio-Plex suspension array system: IL-4, IL-6, IL-10, IL-Ira, IL-12p70, IFNγ, IL-7, IL-8, MCP-1, MIP-1β, eotaxin, IP-10, IL-1β, TNFα, GM-CSF, G-CSF, FGF basic and VEGF. Results: Significant differences between the two groups were evident from 6 hours postexercise onwards with the African runners maintaining significantly higher relative cytokine concentrations. IL-6 serum concentrations of the African runners, for example, ranged from 8% to 55.1% higher than that of the Caucasian runners from 6 hours to 2 weeks postexercise (P<0.05). Conclusions: The study demonstrated that the cytokine response to a bout of downhill running differs between African and Caucasian runners indicating that ethnicity may play a role in exercise-induced immune and inflammatory responses.

KW - Cytokines

KW - Ethnic groups

KW - Exercise

KW - Inflammation

KW - Running

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UR - https://www.minervamedica.it/en/journals/sports-med-physical-fitness/article.php?cod=R40Y2016N06A0665

M3 - Article

VL - 56

SP - 665

EP - 677

JO - Journal of Sports Medicine and Physical Fitness

JF - Journal of Sports Medicine and Physical Fitness

SN - 0022-4707

IS - 6

ER -