Dihydrotestosterone is elevated following sprint exercise in healthy young men

A.A. Smith, R. Toone, O. Peacock, S. Drawer, K.A. Stokes, C.J. Cook

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dihydrotestosterone (DHT) exerts both functional and signaling effects extending beyond the effects of testosterone in rodent skeletal muscle. As a primer for investigating the role of DHT in human skeletal muscle function, this study aimed to determine whether circulating DHT is acutely elevated in men following a bout of repeat sprint exercise and to establish the importance of training status and sprint performance to this response. Fourteen healthy active young men (V̇O2max 61.0 ± 8.1 ml·kg body mass-1·min-1) performed a bout of repeat sprint cycle exercise at a target workload based on an incremental work-rate maximum (10 × 30 s at 150% Wmax with 90-recovery). Venous blood samples were collected preexercise and 5 and 60 min after exercise. Five minutes after exercise, there were significant elevations in total testosterone (TT; P < 0.001), free testosterone (FT; P < 0.001), and DHT (P = 0.004), which returned to baseline after 1 h. Changes in DHT with exercise (5 min postexercise - preexercise) correlated significantly with changes in TT (r = 0.870; P < 0.001) and FT (r = 0.914; P < 0.001). Sprinting cadence correlated with changes in FT (r = 0.697; P = 0.006), DHT (r = 0.625; P = 0.017), and TT (r = 0.603; P = 0.022), and habitual training volume correlated with the change in TT (r = 0.569, P = 0.034). In conclusion, our data demonstrate that DHT is acutely elevated following sprint cycle exercise and that this response is influenced by cycling cadence. The importance of DHT in the context of exercise training and sports performance remains to be determined. Copyright © 2013 the American Physiological Society.
Original languageEnglish
Pages (from-to)1435-1440
Number of pages6
JournalJournal of Applied Physiology
Volume114
Issue number10
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Dihydrotestosterone
Exercise
Testosterone
Skeletal Muscle
Athletic Performance
Workload
Rodentia

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Smith, A. A., Toone, R., Peacock, O., Drawer, S., Stokes, K. A., & Cook, C. J. (2013). Dihydrotestosterone is elevated following sprint exercise in healthy young men. Journal of Applied Physiology, 114(10), 1435-1440. https://doi.org/10.1152/japplphysiol.01419.2012
Smith, A.A. ; Toone, R. ; Peacock, O. ; Drawer, S. ; Stokes, K.A. ; Cook, C.J. / Dihydrotestosterone is elevated following sprint exercise in healthy young men. In: Journal of Applied Physiology. 2013 ; Vol. 114, No. 10. pp. 1435-1440.
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Smith, AA, Toone, R, Peacock, O, Drawer, S, Stokes, KA & Cook, CJ 2013, 'Dihydrotestosterone is elevated following sprint exercise in healthy young men', Journal of Applied Physiology, vol. 114, no. 10, pp. 1435-1440. https://doi.org/10.1152/japplphysiol.01419.2012

Dihydrotestosterone is elevated following sprint exercise in healthy young men. / Smith, A.A.; Toone, R.; Peacock, O.; Drawer, S.; Stokes, K.A.; Cook, C.J.

In: Journal of Applied Physiology, Vol. 114, No. 10, 2013, p. 1435-1440.

Research output: Contribution to journalArticle

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T1 - Dihydrotestosterone is elevated following sprint exercise in healthy young men

AU - Smith, A.A.

AU - Toone, R.

AU - Peacock, O.

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PY - 2013

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AB - Dihydrotestosterone (DHT) exerts both functional and signaling effects extending beyond the effects of testosterone in rodent skeletal muscle. As a primer for investigating the role of DHT in human skeletal muscle function, this study aimed to determine whether circulating DHT is acutely elevated in men following a bout of repeat sprint exercise and to establish the importance of training status and sprint performance to this response. Fourteen healthy active young men (V̇O2max 61.0 ± 8.1 ml·kg body mass-1·min-1) performed a bout of repeat sprint cycle exercise at a target workload based on an incremental work-rate maximum (10 × 30 s at 150% Wmax with 90-recovery). Venous blood samples were collected preexercise and 5 and 60 min after exercise. Five minutes after exercise, there were significant elevations in total testosterone (TT; P < 0.001), free testosterone (FT; P < 0.001), and DHT (P = 0.004), which returned to baseline after 1 h. Changes in DHT with exercise (5 min postexercise - preexercise) correlated significantly with changes in TT (r = 0.870; P < 0.001) and FT (r = 0.914; P < 0.001). Sprinting cadence correlated with changes in FT (r = 0.697; P = 0.006), DHT (r = 0.625; P = 0.017), and TT (r = 0.603; P = 0.022), and habitual training volume correlated with the change in TT (r = 0.569, P = 0.034). In conclusion, our data demonstrate that DHT is acutely elevated following sprint cycle exercise and that this response is influenced by cycling cadence. The importance of DHT in the context of exercise training and sports performance remains to be determined. Copyright © 2013 the American Physiological Society.

KW - Androgens

KW - Exercise training

KW - Sprint cycling

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