Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis

Ali Zaid, Nestor Rulli, Michael Rolph, Andreas Suhrbier, Suresh Mahalingam

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE: Mosquito-borne alphaviruses such as chikungunya virus, O'nyong-nyong virus and Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. Here we test the effect of treating RRV-induced arthritis using the anti-TNF drug, etanercept, in a mouse model of rheumatic disease. METHODS: Mice were infected with RRV and treated with etanercept. Weight loss, tissue viral titers and histological examination of muscle and joint tissues were undertaken. RESULTS: RRV-infected mice treated with etanercept showed increased weight loss, higher viral titres in muscle, joints and blood, more tissue damage and inflammatory cell recruitment than RRV-infected mice without treatment. CONCLUSION: Anti-TNF therapy is unlikely to have utility in treating alphaviral arthritides. During alphaviral epidemics careful monitoring of patients being treated with anti-TNF drugs may be warranted.
Original languageEnglish
Pages (from-to)488-491
Number of pages4
JournalArthritis and Rheumatism (Online)
Volume63
Issue number2
DOIs
Publication statusPublished - 2011

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Ross River virus
Myositis
Arthritis
Disease Progression
Rheumatic Diseases
O'nyong-nyong Virus
Weight Loss
Joints
Chikungunya virus
Alphavirus
Muscles
Physiologic Monitoring
Culicidae
Pharmaceutical Preparations
Disease Outbreaks
Etanercept

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Zaid, Ali ; Rulli, Nestor ; Rolph, Michael ; Suhrbier, Andreas ; Mahalingam, Suresh. / Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis. In: Arthritis and Rheumatism (Online). 2011 ; Vol. 63, No. 2. pp. 488-491.
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Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis. / Zaid, Ali; Rulli, Nestor; Rolph, Michael; Suhrbier, Andreas; Mahalingam, Suresh.

In: Arthritis and Rheumatism (Online), Vol. 63, No. 2, 2011, p. 488-491.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis

AU - Zaid, Ali

AU - Rulli, Nestor

AU - Rolph, Michael

AU - Suhrbier, Andreas

AU - Mahalingam, Suresh

PY - 2011

Y1 - 2011

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AB - OBJECTIVE: Mosquito-borne alphaviruses such as chikungunya virus, O'nyong-nyong virus and Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. Here we test the effect of treating RRV-induced arthritis using the anti-TNF drug, etanercept, in a mouse model of rheumatic disease. METHODS: Mice were infected with RRV and treated with etanercept. Weight loss, tissue viral titers and histological examination of muscle and joint tissues were undertaken. RESULTS: RRV-infected mice treated with etanercept showed increased weight loss, higher viral titres in muscle, joints and blood, more tissue damage and inflammatory cell recruitment than RRV-infected mice without treatment. CONCLUSION: Anti-TNF therapy is unlikely to have utility in treating alphaviral arthritides. During alphaviral epidemics careful monitoring of patients being treated with anti-TNF drugs may be warranted.

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