Disease exacerbation by etanercept in a mouse model of alphaviral arthritis and myositis

Ali Zaid, Nestor Rulli, Michael Rolph, Andreas Suhrbier, Suresh Mahalingam

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

OBJECTIVE: Mosquito-borne alphaviruses such as chikungunya virus, O'nyong-nyong virus and Ross River virus (RRV) cause sporadic, sometimes large, outbreaks of rheumatic disease worldwide. Here we test the effect of treating RRV-induced arthritis using the anti-TNF drug, etanercept, in a mouse model of rheumatic disease. METHODS: Mice were infected with RRV and treated with etanercept. Weight loss, tissue viral titers and histological examination of muscle and joint tissues were undertaken. RESULTS: RRV-infected mice treated with etanercept showed increased weight loss, higher viral titres in muscle, joints and blood, more tissue damage and inflammatory cell recruitment than RRV-infected mice without treatment. CONCLUSION: Anti-TNF therapy is unlikely to have utility in treating alphaviral arthritides. During alphaviral epidemics careful monitoring of patients being treated with anti-TNF drugs may be warranted.
Original languageEnglish
Pages (from-to)488-491
Number of pages4
JournalArthritis and Rheumatism (Online)
Volume63
Issue number2
DOIs
Publication statusPublished - 2011

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