Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study

Robert C. Reiner, Helen Elizabeth Olsen, Chad Ikeda, Michelle Echko, Katherine E. Ballesteros, Helena Manguerra, Ira Martopullo, Anoushka I. Millear, Chloe Shields, Alison Smith, Bryan Strub, Molla Abebe, Zegeye Abebe, Beyene Meressa Adhena, Tara Ballav Adhikari, Mohammed Akibu, Rajaa Al-Raddadi, Nelson Alvis-Guzman, Carl Abelardo T. Antonio, Olatunde Aremu & 100 others Solomon Weldegebreal Asgedom, Netsanet Abera Asseffa, Leticia Avila-Burgos, Aleksandra Barac, Till Bärnighausen, Quique Bassat, Isabela M. Bensenor, Zulfiqar Bhutta, Ali Bijani, Nigus Bililign, Lucero Cahuana-Hurtado, Deborah Carvalho Malta, Jung Chen Chang, Fiona Charlson, Samath Dhamminda Dharmaratne, David Teye Doku, Dumessa Edessa, Ziad El-Khatib, Holly E. Erskine, Alize J. Ferrari, Nancy Fullman, Rahul Gupta, Hamid Yimam Hassen, Simon I Hay, Olayinka Stephen Ilesanmi, Kathryn H. Jacobsen, Amaha Kahsay, Amir Kasaeian, Tesfaye Dessale Kassa, Seifu Kebede, Yousef Saleh Khader, Ejaz Ahmad Khan, Mohammed Nuruzzaman Khan, Young-Ho Khang, Jagdish Khubchandani, Yohannes KINFU, Sonali Kochhar, Yoshihiro Kokubo, Ai Koyanagi, Barthelemy Kuate Defo, Dharmesh Kumar Lal, Fekede Asefa Kumsa, Heidi J Larson, Janni Leung, Abdullah A Mamun, Suresh Mehata, Mulugeta Melku, Walter Mendoza, Haftay Berhane Mezgebe, Ted Miller, Nurilign Abebe Moges, Shafiu Mohammed, Ali H Mokdad, Lorenzo Monasta, Subas Neupane, Huong Lan Thi Nguyen, Dina Nur Anggraini Ningrum, Yirga Legesse Nirayo, Vuong Minh Nong, Felix Akpojene Ogbo, Andrew Toyin Olagunju, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, George C Patton, David M Pereira, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Rajesh Kumar Rai, Usha Ram, Chhabi Lal Ranabhat, Andre M. N. Renzaho, Mohammad Sadegh Rezai, Luca Ronfani, Gregory A. Roth, Saeid Safiri, Benn Sartorius, James G. Scott, Katya Anne Shackelford, Karen Sliwa, Chandrashekhar Sreeramareddy, Mu'awiyyah Bable Sufiyan, Abdullah Sulieman Terkawi, Roman Topor-Madry, Bach Xuan Tran, Kingsley Nnanna Ukwaja, Olalekan A Uthman, Stein Emil Vollset, Kidu Gidey Weldegwergs, Andrea Werdecker, Harvey A. Whiteford, Tissa Wijeratne, Naohiro Yonemoto, Marcel Yotebieng, Liesl J. Zuhlke, Hmwe Hmwe Kyu, Mohsen Naghavi, Theo Vos, Christopher J L Murray, Nicholas J Kassebaum

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Importance: Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective: To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants: This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income, educational attainment, and fertility. Data collected from 1990 to 2017 on children and adolescents from birth through 19 years of age in 195 countries and territories were assessed. Data analysis occurred from January 2018 to August 2018. Exposures: Being under the age of 20 years between 1990 and 2017. Main Outcomes and Measures: Death and disability. All-cause and cause-specific deaths, disability-adjusted life years, years of life lost, and years of life lived with disability. Results: Child and adolescent deaths decreased 51.7% from 13.77 million (95% uncertainty interval [UI], 13.60-13.93 million) in 1990 to 6.64 million (95% UI, 6.44-6.87 million) in 2017, but in 2017, but aggregate disability increased 4.7% to a total of 145 million (95% UI, 107-190 million) years lived with disability globally. Progress was uneven, and inequity increased, with low-SDI and low-middle-SDI locations experiencing 82.2% (95% UI, 81.6%-82.9%) of deaths, up from 70.9% (95% UI, 70.4%-71.4%) in 1990. The leading disaggregated causes of disability-adjusted life years in 2017 in the low-SDI quintile were neonatal disorders, lower respiratory infections, diarrhea, malaria, and congenital birth defects, whereas neonatal disorders, congenital birth defects, headache, dermatitis, and anxiety were highest-ranked in the high-SDI quintile. Conclusions and Relevance: Mortality reductions over this 27-year period mean that children are more likely than ever to reach their 20th birthdays. The concomitant expansion of nonfatal health loss and epidemiological transition in children and adolescents, especially in low-SDI and middle-SDI countries, has the potential to increase already overburdened health systems, will affect the human capital potential of societies, and may influence the trajectory of socioeconomic development. Continued monitoring of child and adolescent health loss is crucial to sustain the progress of the past 27 years..

LanguageEnglish
Pages1-17
Number of pages17
JournalJAMA Pediatrics
DOIs
Publication statusPublished - 2019

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Demography
Uncertainty
Wounds and Injuries
Quality-Adjusted Life Years
Health
Mortality
Statistical Data Interpretation
Dermatitis
Child Health
Adolescent Health
Global Burden of Disease
Respiratory Tract Infections
Malaria
Fertility
Headache
Cause of Death
Diarrhea
Anxiety
Economics
Outcome Assessment (Health Care)

Cite this

Reiner, Robert C. ; Olsen, Helen Elizabeth ; Ikeda, Chad ; Echko, Michelle ; Ballesteros, Katherine E. ; Manguerra, Helena ; Martopullo, Ira ; Millear, Anoushka I. ; Shields, Chloe ; Smith, Alison ; Strub, Bryan ; Abebe, Molla ; Abebe, Zegeye ; Adhena, Beyene Meressa ; Adhikari, Tara Ballav ; Akibu, Mohammed ; Al-Raddadi, Rajaa ; Alvis-Guzman, Nelson ; Antonio, Carl Abelardo T. ; Aremu, Olatunde ; Asgedom, Solomon Weldegebreal ; Asseffa, Netsanet Abera ; Avila-Burgos, Leticia ; Barac, Aleksandra ; Bärnighausen, Till ; Bassat, Quique ; Bensenor, Isabela M. ; Bhutta, Zulfiqar ; Bijani, Ali ; Bililign, Nigus ; Cahuana-Hurtado, Lucero ; Malta, Deborah Carvalho ; Chang, Jung Chen ; Charlson, Fiona ; Dharmaratne, Samath Dhamminda ; Doku, David Teye ; Edessa, Dumessa ; El-Khatib, Ziad ; Erskine, Holly E. ; Ferrari, Alize J. ; Fullman, Nancy ; Gupta, Rahul ; Hassen, Hamid Yimam ; Hay, Simon I ; Stephen Ilesanmi, Olayinka ; Jacobsen, Kathryn H. ; Kahsay, Amaha ; Kasaeian, Amir ; Kassa, Tesfaye Dessale ; Kebede, Seifu ; Khader, Yousef Saleh ; Khan, Ejaz Ahmad ; Khan, Mohammed Nuruzzaman ; Khang, Young-Ho ; Khubchandani, Jagdish ; KINFU, Yohannes ; Kochhar, Sonali ; Kokubo, Yoshihiro ; Koyanagi, Ai ; Defo, Barthelemy Kuate ; Lal, Dharmesh Kumar ; Kumsa, Fekede Asefa ; Larson, Heidi J ; Leung, Janni ; Mamun, Abdullah A ; Mehata, Suresh ; Melku, Mulugeta ; Mendoza, Walter ; Mezgebe, Haftay Berhane ; Miller, Ted ; Moges, Nurilign Abebe ; Mohammed, Shafiu ; Mokdad, Ali H ; Monasta, Lorenzo ; Neupane, Subas ; Nguyen, Huong Lan Thi ; Ningrum, Dina Nur Anggraini ; Nirayo, Yirga Legesse ; Nong, Vuong Minh ; Ogbo, Felix Akpojene ; Olagunju, Andrew Toyin ; Olusanya, Bolajoko Olubukunola ; Olusanya, Jacob Olusegun ; Patton, George C ; Pereira, David M ; Pourmalek, Farshad ; Qorbani, Mostafa ; Rafay, Anwar ; Rai, Rajesh Kumar ; Ram, Usha ; Ranabhat, Chhabi Lal ; Renzaho, Andre M. N. ; Rezai, Mohammad Sadegh ; Ronfani, Luca ; Roth, Gregory A. ; Safiri, Saeid ; Sartorius, Benn ; Scott, James G. ; Shackelford, Katya Anne ; Sliwa, Karen ; Sreeramareddy, Chandrashekhar ; Sufiyan, Mu'awiyyah Bable ; Terkawi, Abdullah Sulieman ; Topor-Madry, Roman ; Tran, Bach Xuan ; Ukwaja, Kingsley Nnanna ; Uthman, Olalekan A ; Vollset, Stein Emil ; Weldegwergs, Kidu Gidey ; Werdecker, Andrea ; Whiteford, Harvey A. ; Wijeratne, Tissa ; Yonemoto, Naohiro ; Yotebieng, Marcel ; Zuhlke, Liesl J. ; Kyu, Hmwe Hmwe ; Naghavi, Mohsen ; Vos, Theo ; Murray, Christopher J L ; Kassebaum, Nicholas J . / Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017 : Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study. In: JAMA Pediatrics. 2019 ; pp. 1-17.
@article{9e1e8c35fd4a411a9c5f998275ae8cb3,
title = "Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study",
abstract = "Importance: Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective: To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants: This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income, educational attainment, and fertility. Data collected from 1990 to 2017 on children and adolescents from birth through 19 years of age in 195 countries and territories were assessed. Data analysis occurred from January 2018 to August 2018. Exposures: Being under the age of 20 years between 1990 and 2017. Main Outcomes and Measures: Death and disability. All-cause and cause-specific deaths, disability-adjusted life years, years of life lost, and years of life lived with disability. Results: Child and adolescent deaths decreased 51.7{\%} from 13.77 million (95{\%} uncertainty interval [UI], 13.60-13.93 million) in 1990 to 6.64 million (95{\%} UI, 6.44-6.87 million) in 2017, but in 2017, but aggregate disability increased 4.7{\%} to a total of 145 million (95{\%} UI, 107-190 million) years lived with disability globally. Progress was uneven, and inequity increased, with low-SDI and low-middle-SDI locations experiencing 82.2{\%} (95{\%} UI, 81.6{\%}-82.9{\%}) of deaths, up from 70.9{\%} (95{\%} UI, 70.4{\%}-71.4{\%}) in 1990. The leading disaggregated causes of disability-adjusted life years in 2017 in the low-SDI quintile were neonatal disorders, lower respiratory infections, diarrhea, malaria, and congenital birth defects, whereas neonatal disorders, congenital birth defects, headache, dermatitis, and anxiety were highest-ranked in the high-SDI quintile. Conclusions and Relevance: Mortality reductions over this 27-year period mean that children are more likely than ever to reach their 20th birthdays. The concomitant expansion of nonfatal health loss and epidemiological transition in children and adolescents, especially in low-SDI and middle-SDI countries, has the potential to increase already overburdened health systems, will affect the human capital potential of societies, and may influence the trajectory of socioeconomic development. Continued monitoring of child and adolescent health loss is crucial to sustain the progress of the past 27 years..",
author = "Reiner, {Robert C.} and Olsen, {Helen Elizabeth} and Chad Ikeda and Michelle Echko and Ballesteros, {Katherine E.} and Helena Manguerra and Ira Martopullo and Millear, {Anoushka I.} and Chloe Shields and Alison Smith and Bryan Strub and Molla Abebe and Zegeye Abebe and Adhena, {Beyene Meressa} and Adhikari, {Tara Ballav} and Mohammed Akibu and Rajaa Al-Raddadi and Nelson Alvis-Guzman and Antonio, {Carl Abelardo T.} and Olatunde Aremu and Asgedom, {Solomon Weldegebreal} and Asseffa, {Netsanet Abera} and Leticia Avila-Burgos and Aleksandra Barac and Till B{\"a}rnighausen and Quique Bassat and Bensenor, {Isabela M.} and Zulfiqar Bhutta and Ali Bijani and Nigus Bililign and Lucero Cahuana-Hurtado and Malta, {Deborah Carvalho} and Chang, {Jung Chen} and Fiona Charlson and Dharmaratne, {Samath Dhamminda} and Doku, {David Teye} and Dumessa Edessa and Ziad El-Khatib and Erskine, {Holly E.} and Ferrari, {Alize J.} and Nancy Fullman and Rahul Gupta and Hassen, {Hamid Yimam} and Hay, {Simon I} and {Stephen Ilesanmi}, Olayinka and Jacobsen, {Kathryn H.} and Amaha Kahsay and Amir Kasaeian and Kassa, {Tesfaye Dessale} and Seifu Kebede and Khader, {Yousef Saleh} and Khan, {Ejaz Ahmad} and Khan, {Mohammed Nuruzzaman} and Young-Ho Khang and Jagdish Khubchandani and Yohannes KINFU and Sonali Kochhar and Yoshihiro Kokubo and Ai Koyanagi and Defo, {Barthelemy Kuate} and Lal, {Dharmesh Kumar} and Kumsa, {Fekede Asefa} and Larson, {Heidi J} and Janni Leung and Mamun, {Abdullah A} and Suresh Mehata and Mulugeta Melku and Walter Mendoza and Mezgebe, {Haftay Berhane} and Ted Miller and Moges, {Nurilign Abebe} and Shafiu Mohammed and Mokdad, {Ali H} and Lorenzo Monasta and Subas Neupane and Nguyen, {Huong Lan Thi} and Ningrum, {Dina Nur Anggraini} and Nirayo, {Yirga Legesse} and Nong, {Vuong Minh} and Ogbo, {Felix Akpojene} and Olagunju, {Andrew Toyin} and Olusanya, {Bolajoko Olubukunola} and Olusanya, {Jacob Olusegun} and Patton, {George C} and Pereira, {David M} and Farshad Pourmalek and Mostafa Qorbani and Anwar Rafay and Rai, {Rajesh Kumar} and Usha Ram and Ranabhat, {Chhabi Lal} and Renzaho, {Andre M. N.} and Rezai, {Mohammad Sadegh} and Luca Ronfani and Roth, {Gregory A.} and Saeid Safiri and Benn Sartorius and Scott, {James G.} and Shackelford, {Katya Anne} and Karen Sliwa and Chandrashekhar Sreeramareddy and Sufiyan, {Mu'awiyyah Bable} and Terkawi, {Abdullah Sulieman} and Roman Topor-Madry and Tran, {Bach Xuan} and Ukwaja, {Kingsley Nnanna} and Uthman, {Olalekan A} and Vollset, {Stein Emil} and Weldegwergs, {Kidu Gidey} and Andrea Werdecker and Whiteford, {Harvey A.} and Tissa Wijeratne and Naohiro Yonemoto and Marcel Yotebieng and Zuhlke, {Liesl J.} and Kyu, {Hmwe Hmwe} and Mohsen Naghavi and Theo Vos and Murray, {Christopher J L} and Kassebaum, {Nicholas J}",
year = "2019",
doi = "10.1001/jamapediatrics.2019.0337",
language = "English",
pages = "1--17",
journal = "Archives of Pediatrics and Adolescent Medicine",
issn = "1072-4710",
publisher = "American Medical Association",

}

Reiner, RC, Olsen, HE, Ikeda, C, Echko, M, Ballesteros, KE, Manguerra, H, Martopullo, I, Millear, AI, Shields, C, Smith, A, Strub, B, Abebe, M, Abebe, Z, Adhena, BM, Adhikari, TB, Akibu, M, Al-Raddadi, R, Alvis-Guzman, N, Antonio, CAT, Aremu, O, Asgedom, SW, Asseffa, NA, Avila-Burgos, L, Barac, A, Bärnighausen, T, Bassat, Q, Bensenor, IM, Bhutta, Z, Bijani, A, Bililign, N, Cahuana-Hurtado, L, Malta, DC, Chang, JC, Charlson, F, Dharmaratne, SD, Doku, DT, Edessa, D, El-Khatib, Z, Erskine, HE, Ferrari, AJ, Fullman, N, Gupta, R, Hassen, HY, Hay, SI, Stephen Ilesanmi, O, Jacobsen, KH, Kahsay, A, Kasaeian, A, Kassa, TD, Kebede, S, Khader, YS, Khan, EA, Khan, MN, Khang, Y-H, Khubchandani, J, KINFU, Y, Kochhar, S, Kokubo, Y, Koyanagi, A, Defo, BK, Lal, DK, Kumsa, FA, Larson, HJ, Leung, J, Mamun, AA, Mehata, S, Melku, M, Mendoza, W, Mezgebe, HB, Miller, T, Moges, NA, Mohammed, S, Mokdad, AH, Monasta, L, Neupane, S, Nguyen, HLT, Ningrum, DNA, Nirayo, YL, Nong, VM, Ogbo, FA, Olagunju, AT, Olusanya, BO, Olusanya, JO, Patton, GC, Pereira, DM, Pourmalek, F, Qorbani, M, Rafay, A, Rai, RK, Ram, U, Ranabhat, CL, Renzaho, AMN, Rezai, MS, Ronfani, L, Roth, GA, Safiri, S, Sartorius, B, Scott, JG, Shackelford, KA, Sliwa, K, Sreeramareddy, C, Sufiyan, MB, Terkawi, AS, Topor-Madry, R, Tran, BX, Ukwaja, KN, Uthman, OA, Vollset, SE, Weldegwergs, KG, Werdecker, A, Whiteford, HA, Wijeratne, T, Yonemoto, N, Yotebieng, M, Zuhlke, LJ, Kyu, HH, Naghavi, M, Vos, T, Murray, CJL & Kassebaum, NJ 2019, 'Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study', JAMA Pediatrics, pp. 1-17. https://doi.org/10.1001/jamapediatrics.2019.0337

Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017 : Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study. / Reiner, Robert C.; Olsen, Helen Elizabeth ; Ikeda, Chad; Echko, Michelle; Ballesteros, Katherine E.; Manguerra, Helena; Martopullo, Ira ; Millear, Anoushka I.; Shields, Chloe; Smith, Alison; Strub, Bryan; Abebe, Molla; Abebe, Zegeye; Adhena, Beyene Meressa; Adhikari, Tara Ballav; Akibu, Mohammed; Al-Raddadi, Rajaa; Alvis-Guzman, Nelson; Antonio, Carl Abelardo T.; Aremu, Olatunde; Asgedom, Solomon Weldegebreal; Asseffa, Netsanet Abera; Avila-Burgos, Leticia; Barac, Aleksandra; Bärnighausen, Till; Bassat, Quique; Bensenor, Isabela M.; Bhutta, Zulfiqar; Bijani, Ali; Bililign, Nigus; Cahuana-Hurtado, Lucero; Malta, Deborah Carvalho ; Chang, Jung Chen; Charlson, Fiona; Dharmaratne, Samath Dhamminda; Doku, David Teye; Edessa, Dumessa; El-Khatib, Ziad; Erskine, Holly E.; Ferrari, Alize J.; Fullman, Nancy; Gupta, Rahul; Hassen, Hamid Yimam; Hay, Simon I; Stephen Ilesanmi, Olayinka ; Jacobsen, Kathryn H.; Kahsay, Amaha ; Kasaeian, Amir; Kassa, Tesfaye Dessale ; Kebede, Seifu ; Khader, Yousef Saleh; Khan, Ejaz Ahmad; Khan, Mohammed Nuruzzaman ; Khang, Young-Ho; Khubchandani, Jagdish; KINFU, Yohannes; Kochhar, Sonali ; Kokubo, Yoshihiro; Koyanagi, Ai; Defo, Barthelemy Kuate; Lal, Dharmesh Kumar; Kumsa, Fekede Asefa ; Larson, Heidi J; Leung, Janni; Mamun, Abdullah A ; Mehata, Suresh ; Melku, Mulugeta ; Mendoza, Walter; Mezgebe, Haftay Berhane ; Miller, Ted; Moges, Nurilign Abebe ; Mohammed, Shafiu ; Mokdad, Ali H; Monasta, Lorenzo; Neupane, Subas ; Nguyen, Huong Lan Thi ; Ningrum, Dina Nur Anggraini; Nirayo, Yirga Legesse ; Nong, Vuong Minh; Ogbo, Felix Akpojene ; Olagunju, Andrew Toyin; Olusanya, Bolajoko Olubukunola ; Olusanya, Jacob Olusegun ; Patton, George C; Pereira, David M ; Pourmalek, Farshad; Qorbani, Mostafa; Rafay, Anwar; Rai, Rajesh Kumar ; Ram, Usha ; Ranabhat, Chhabi Lal; Renzaho, Andre M. N. ; Rezai, Mohammad Sadegh ; Ronfani, Luca; Roth, Gregory A.; Safiri, Saeid; Sartorius, Benn; Scott, James G. ; Shackelford, Katya Anne ; Sliwa, Karen; Sreeramareddy, Chandrashekhar; Sufiyan, Mu'awiyyah Bable ; Terkawi, Abdullah Sulieman ; Topor-Madry, Roman; Tran, Bach Xuan ; Ukwaja, Kingsley Nnanna; Uthman, Olalekan A; Vollset, Stein Emil; Weldegwergs, Kidu Gidey ; Werdecker, Andrea; Whiteford, Harvey A.; Wijeratne, Tissa ; Yonemoto, Naohiro; Yotebieng, Marcel; Zuhlke, Liesl J. ; Kyu, Hmwe Hmwe; Naghavi, Mohsen; Vos, Theo; Murray, Christopher J L; Kassebaum, Nicholas J .

In: JAMA Pediatrics, 2019, p. 1-17.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017

T2 - Archives of Pediatrics and Adolescent Medicine

AU - Reiner, Robert C.

AU - Olsen, Helen Elizabeth

AU - Ikeda, Chad

AU - Echko, Michelle

AU - Ballesteros, Katherine E.

AU - Manguerra, Helena

AU - Martopullo, Ira

AU - Millear, Anoushka I.

AU - Shields, Chloe

AU - Smith, Alison

AU - Strub, Bryan

AU - Abebe, Molla

AU - Abebe, Zegeye

AU - Adhena, Beyene Meressa

AU - Adhikari, Tara Ballav

AU - Akibu, Mohammed

AU - Al-Raddadi, Rajaa

AU - Alvis-Guzman, Nelson

AU - Antonio, Carl Abelardo T.

AU - Aremu, Olatunde

AU - Asgedom, Solomon Weldegebreal

AU - Asseffa, Netsanet Abera

AU - Avila-Burgos, Leticia

AU - Barac, Aleksandra

AU - Bärnighausen, Till

AU - Bassat, Quique

AU - Bensenor, Isabela M.

AU - Bhutta, Zulfiqar

AU - Bijani, Ali

AU - Bililign, Nigus

AU - Cahuana-Hurtado, Lucero

AU - Malta, Deborah Carvalho

AU - Chang, Jung Chen

AU - Charlson, Fiona

AU - Dharmaratne, Samath Dhamminda

AU - Doku, David Teye

AU - Edessa, Dumessa

AU - El-Khatib, Ziad

AU - Erskine, Holly E.

AU - Ferrari, Alize J.

AU - Fullman, Nancy

AU - Gupta, Rahul

AU - Hassen, Hamid Yimam

AU - Hay, Simon I

AU - Stephen Ilesanmi, Olayinka

AU - Jacobsen, Kathryn H.

AU - Kahsay, Amaha

AU - Kasaeian, Amir

AU - Kassa, Tesfaye Dessale

AU - Kebede, Seifu

AU - Khader, Yousef Saleh

AU - Khan, Ejaz Ahmad

AU - Khan, Mohammed Nuruzzaman

AU - Khang, Young-Ho

AU - Khubchandani, Jagdish

AU - KINFU, Yohannes

AU - Kochhar, Sonali

AU - Kokubo, Yoshihiro

AU - Koyanagi, Ai

AU - Defo, Barthelemy Kuate

AU - Lal, Dharmesh Kumar

AU - Kumsa, Fekede Asefa

AU - Larson, Heidi J

AU - Leung, Janni

AU - Mamun, Abdullah A

AU - Mehata, Suresh

AU - Melku, Mulugeta

AU - Mendoza, Walter

AU - Mezgebe, Haftay Berhane

AU - Miller, Ted

AU - Moges, Nurilign Abebe

AU - Mohammed, Shafiu

AU - Mokdad, Ali H

AU - Monasta, Lorenzo

AU - Neupane, Subas

AU - Nguyen, Huong Lan Thi

AU - Ningrum, Dina Nur Anggraini

AU - Nirayo, Yirga Legesse

AU - Nong, Vuong Minh

AU - Ogbo, Felix Akpojene

AU - Olagunju, Andrew Toyin

AU - Olusanya, Bolajoko Olubukunola

AU - Olusanya, Jacob Olusegun

AU - Patton, George C

AU - Pereira, David M

AU - Pourmalek, Farshad

AU - Qorbani, Mostafa

AU - Rafay, Anwar

AU - Rai, Rajesh Kumar

AU - Ram, Usha

AU - Ranabhat, Chhabi Lal

AU - Renzaho, Andre M. N.

AU - Rezai, Mohammad Sadegh

AU - Ronfani, Luca

AU - Roth, Gregory A.

AU - Safiri, Saeid

AU - Sartorius, Benn

AU - Scott, James G.

AU - Shackelford, Katya Anne

AU - Sliwa, Karen

AU - Sreeramareddy, Chandrashekhar

AU - Sufiyan, Mu'awiyyah Bable

AU - Terkawi, Abdullah Sulieman

AU - Topor-Madry, Roman

AU - Tran, Bach Xuan

AU - Ukwaja, Kingsley Nnanna

AU - Uthman, Olalekan A

AU - Vollset, Stein Emil

AU - Weldegwergs, Kidu Gidey

AU - Werdecker, Andrea

AU - Whiteford, Harvey A.

AU - Wijeratne, Tissa

AU - Yonemoto, Naohiro

AU - Yotebieng, Marcel

AU - Zuhlke, Liesl J.

AU - Kyu, Hmwe Hmwe

AU - Naghavi, Mohsen

AU - Vos, Theo

AU - Murray, Christopher J L

AU - Kassebaum, Nicholas J

PY - 2019

Y1 - 2019

N2 - Importance: Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective: To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants: This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income, educational attainment, and fertility. Data collected from 1990 to 2017 on children and adolescents from birth through 19 years of age in 195 countries and territories were assessed. Data analysis occurred from January 2018 to August 2018. Exposures: Being under the age of 20 years between 1990 and 2017. Main Outcomes and Measures: Death and disability. All-cause and cause-specific deaths, disability-adjusted life years, years of life lost, and years of life lived with disability. Results: Child and adolescent deaths decreased 51.7% from 13.77 million (95% uncertainty interval [UI], 13.60-13.93 million) in 1990 to 6.64 million (95% UI, 6.44-6.87 million) in 2017, but in 2017, but aggregate disability increased 4.7% to a total of 145 million (95% UI, 107-190 million) years lived with disability globally. Progress was uneven, and inequity increased, with low-SDI and low-middle-SDI locations experiencing 82.2% (95% UI, 81.6%-82.9%) of deaths, up from 70.9% (95% UI, 70.4%-71.4%) in 1990. The leading disaggregated causes of disability-adjusted life years in 2017 in the low-SDI quintile were neonatal disorders, lower respiratory infections, diarrhea, malaria, and congenital birth defects, whereas neonatal disorders, congenital birth defects, headache, dermatitis, and anxiety were highest-ranked in the high-SDI quintile. Conclusions and Relevance: Mortality reductions over this 27-year period mean that children are more likely than ever to reach their 20th birthdays. The concomitant expansion of nonfatal health loss and epidemiological transition in children and adolescents, especially in low-SDI and middle-SDI countries, has the potential to increase already overburdened health systems, will affect the human capital potential of societies, and may influence the trajectory of socioeconomic development. Continued monitoring of child and adolescent health loss is crucial to sustain the progress of the past 27 years..

AB - Importance: Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective: To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants: This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income, educational attainment, and fertility. Data collected from 1990 to 2017 on children and adolescents from birth through 19 years of age in 195 countries and territories were assessed. Data analysis occurred from January 2018 to August 2018. Exposures: Being under the age of 20 years between 1990 and 2017. Main Outcomes and Measures: Death and disability. All-cause and cause-specific deaths, disability-adjusted life years, years of life lost, and years of life lived with disability. Results: Child and adolescent deaths decreased 51.7% from 13.77 million (95% uncertainty interval [UI], 13.60-13.93 million) in 1990 to 6.64 million (95% UI, 6.44-6.87 million) in 2017, but in 2017, but aggregate disability increased 4.7% to a total of 145 million (95% UI, 107-190 million) years lived with disability globally. Progress was uneven, and inequity increased, with low-SDI and low-middle-SDI locations experiencing 82.2% (95% UI, 81.6%-82.9%) of deaths, up from 70.9% (95% UI, 70.4%-71.4%) in 1990. The leading disaggregated causes of disability-adjusted life years in 2017 in the low-SDI quintile were neonatal disorders, lower respiratory infections, diarrhea, malaria, and congenital birth defects, whereas neonatal disorders, congenital birth defects, headache, dermatitis, and anxiety were highest-ranked in the high-SDI quintile. Conclusions and Relevance: Mortality reductions over this 27-year period mean that children are more likely than ever to reach their 20th birthdays. The concomitant expansion of nonfatal health loss and epidemiological transition in children and adolescents, especially in low-SDI and middle-SDI countries, has the potential to increase already overburdened health systems, will affect the human capital potential of societies, and may influence the trajectory of socioeconomic development. Continued monitoring of child and adolescent health loss is crucial to sustain the progress of the past 27 years..

UR - http://www.scopus.com/inward/record.url?scp=85065307750&partnerID=8YFLogxK

U2 - 10.1001/jamapediatrics.2019.0337

DO - 10.1001/jamapediatrics.2019.0337

M3 - Article

SP - 1

EP - 17

JO - Archives of Pediatrics and Adolescent Medicine

JF - Archives of Pediatrics and Adolescent Medicine

SN - 1072-4710

ER -