Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians

David Banham, David Roder, Dorothy Keefe, Gelareh Farshid, Marion Eckert, Margaret Cargo, Alex Brown, CanDAD Aboriginal Community Reference Group and CanDAD Investigators

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aim This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. Methods This test dataset comprised 950 Aboriginal cases and all other cases recorded on the South Australian cancer registry with a 1977–2010 diagnosis. A sub-set of 777 Aboriginal cases diagnosed in 1990–2010 were matched with randomly selected non-Aboriginal cases by year of birth, diagnostic year, sex, and primary site of cancer. Competing risk regression summarised associations of Aboriginal status, stage, and geographic attributes with risk of cancer death. Results Aboriginal cases were 10 years younger at diagnosis, more likely to present in recent diagnostic years, to be resident of remote areas, and have primary cancer sites of head & neck, lung, liver and cervix. Risk of cancer death was associated in the matched analysis with more advanced stage at diagnosis. More Aboriginal than non-Aboriginal cases had distant metastases at diagnosis (31.3% vs 22.0, p < 0.001). After adjusting for stage, remote-living Aboriginal residents had higher risks of cancer death than Aboriginal residents of metropolitan areas. Non-Aboriginal cases had the lowest risk of cancer death. Conclusion Retrospective staging proved to be feasible using registry data. Results indicated more advanced stages for Aboriginal than matched non-Aboriginal cases. Aboriginal people had higher risks of cancer death, which persisted after adjusting for stage, and applied irrespective of remoteness of residence, with highest risk of death occurring among Aboriginal people from remote areas.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalCancer Epidemiology
Volume48
DOIs
Publication statusPublished - Jun 2017
Externally publishedYes

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Neoplasms
Registries
Neoplasm Staging
Head and Neck Neoplasms
Cervix Uteri
Neck
Parturition
Neoplasm Metastasis
Lung
Liver

Cite this

Banham, D., Roder, D., Keefe, D., Farshid, G., Eckert, M., Cargo, M., ... CanDAD Aboriginal Community Reference Group and CanDAD Investigators (2017). Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians. Cancer Epidemiology, 48, 131-139. https://doi.org/10.1016/j.canep.2017.04.013
Banham, David ; Roder, David ; Keefe, Dorothy ; Farshid, Gelareh ; Eckert, Marion ; Cargo, Margaret ; Brown, Alex ; CanDAD Aboriginal Community Reference Group and CanDAD Investigators. / Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians. In: Cancer Epidemiology. 2017 ; Vol. 48. pp. 131-139.
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abstract = "Background/Aim This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. Methods This test dataset comprised 950 Aboriginal cases and all other cases recorded on the South Australian cancer registry with a 1977–2010 diagnosis. A sub-set of 777 Aboriginal cases diagnosed in 1990–2010 were matched with randomly selected non-Aboriginal cases by year of birth, diagnostic year, sex, and primary site of cancer. Competing risk regression summarised associations of Aboriginal status, stage, and geographic attributes with risk of cancer death. Results Aboriginal cases were 10 years younger at diagnosis, more likely to present in recent diagnostic years, to be resident of remote areas, and have primary cancer sites of head & neck, lung, liver and cervix. Risk of cancer death was associated in the matched analysis with more advanced stage at diagnosis. More Aboriginal than non-Aboriginal cases had distant metastases at diagnosis (31.3{\%} vs 22.0, p < 0.001). After adjusting for stage, remote-living Aboriginal residents had higher risks of cancer death than Aboriginal residents of metropolitan areas. Non-Aboriginal cases had the lowest risk of cancer death. Conclusion Retrospective staging proved to be feasible using registry data. Results indicated more advanced stages for Aboriginal than matched non-Aboriginal cases. Aboriginal people had higher risks of cancer death, which persisted after adjusting for stage, and applied irrespective of remoteness of residence, with highest risk of death occurring among Aboriginal people from remote areas.",
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Banham, D, Roder, D, Keefe, D, Farshid, G, Eckert, M, Cargo, M, Brown, A & CanDAD Aboriginal Community Reference Group and CanDAD Investigators 2017, 'Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians', Cancer Epidemiology, vol. 48, pp. 131-139. https://doi.org/10.1016/j.canep.2017.04.013

Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians. / Banham, David; Roder, David; Keefe, Dorothy; Farshid, Gelareh; Eckert, Marion; Cargo, Margaret; Brown, Alex; CanDAD Aboriginal Community Reference Group and CanDAD Investigators.

In: Cancer Epidemiology, Vol. 48, 06.2017, p. 131-139.

Research output: Contribution to journalArticle

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AU - Banham, David

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AU - Farshid, Gelareh

AU - Eckert, Marion

AU - Cargo, Margaret

AU - Brown, Alex

AU - CanDAD Aboriginal Community Reference Group and CanDAD Investigators

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N2 - Background/Aim This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. Methods This test dataset comprised 950 Aboriginal cases and all other cases recorded on the South Australian cancer registry with a 1977–2010 diagnosis. A sub-set of 777 Aboriginal cases diagnosed in 1990–2010 were matched with randomly selected non-Aboriginal cases by year of birth, diagnostic year, sex, and primary site of cancer. Competing risk regression summarised associations of Aboriginal status, stage, and geographic attributes with risk of cancer death. Results Aboriginal cases were 10 years younger at diagnosis, more likely to present in recent diagnostic years, to be resident of remote areas, and have primary cancer sites of head & neck, lung, liver and cervix. Risk of cancer death was associated in the matched analysis with more advanced stage at diagnosis. More Aboriginal than non-Aboriginal cases had distant metastases at diagnosis (31.3% vs 22.0, p < 0.001). After adjusting for stage, remote-living Aboriginal residents had higher risks of cancer death than Aboriginal residents of metropolitan areas. Non-Aboriginal cases had the lowest risk of cancer death. Conclusion Retrospective staging proved to be feasible using registry data. Results indicated more advanced stages for Aboriginal than matched non-Aboriginal cases. Aboriginal people had higher risks of cancer death, which persisted after adjusting for stage, and applied irrespective of remoteness of residence, with highest risk of death occurring among Aboriginal people from remote areas.

AB - Background/Aim This study tested the utility of retrospectively staging cancer registry data for comparing stage and stage-specific survivals of Aboriginal and non-Aboriginal people. Differences by area level factors were also explored. Methods This test dataset comprised 950 Aboriginal cases and all other cases recorded on the South Australian cancer registry with a 1977–2010 diagnosis. A sub-set of 777 Aboriginal cases diagnosed in 1990–2010 were matched with randomly selected non-Aboriginal cases by year of birth, diagnostic year, sex, and primary site of cancer. Competing risk regression summarised associations of Aboriginal status, stage, and geographic attributes with risk of cancer death. Results Aboriginal cases were 10 years younger at diagnosis, more likely to present in recent diagnostic years, to be resident of remote areas, and have primary cancer sites of head & neck, lung, liver and cervix. Risk of cancer death was associated in the matched analysis with more advanced stage at diagnosis. More Aboriginal than non-Aboriginal cases had distant metastases at diagnosis (31.3% vs 22.0, p < 0.001). After adjusting for stage, remote-living Aboriginal residents had higher risks of cancer death than Aboriginal residents of metropolitan areas. Non-Aboriginal cases had the lowest risk of cancer death. Conclusion Retrospective staging proved to be feasible using registry data. Results indicated more advanced stages for Aboriginal than matched non-Aboriginal cases. Aboriginal people had higher risks of cancer death, which persisted after adjusting for stage, and applied irrespective of remoteness of residence, with highest risk of death occurring among Aboriginal people from remote areas.

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KW - Cancer

KW - Cancer stage

KW - Disadvantage

KW - Disparity

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KW - Indigenous

KW - Survival

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