Distribution of fitness in populations of dengue viruses

Md Abu Choudhury; William B. Lott; John Aaskov

doi:10.1371/journal.pone.0107264

Distribution of fitness in populations of dengue viruses

Md Abu Choudhury, William B. Lott, John Aaskov

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Abstract

Genetically diverse RNA viruses like dengue viruses (DENVs) segregate into multiple, genetically distinct, lineages that temporally arise and disappear on a regular basis. Lineage turnover may occur through multiple processes such as, stochastic or due to variations in fitness. To determine the variation of fitness, we measured the distribution of fitness within DENV populations and correlated it with lineage extinction and replacement. The fitness of most members within a population proved lower than the aggregate fitness of populations from which they were drawn, but lineage replacement events were not associated with changes in the distribution of fitness. These data provide insights into variations in fitness of DENV populations, extending our understanding of the complexity between members of individual populations.

Original language	English
Article number	e107264
Pages (from-to)	1-9
Number of pages	9
Journal	PLoS One
Volume	9
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0107264
Publication status	Published - 15 Sept 2014
Externally published	Yes

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ArticleFinal published version, 1.16 MBLicence: CC BY

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AB - Genetically diverse RNA viruses like dengue viruses (DENVs) segregate into multiple, genetically distinct, lineages that temporally arise and disappear on a regular basis. Lineage turnover may occur through multiple processes such as, stochastic or due to variations in fitness. To determine the variation of fitness, we measured the distribution of fitness within DENV populations and correlated it with lineage extinction and replacement. The fitness of most members within a population proved lower than the aggregate fitness of populations from which they were drawn, but lineage replacement events were not associated with changes in the distribution of fitness. These data provide insights into variations in fitness of DENV populations, extending our understanding of the complexity between members of individual populations.

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Distribution of fitness in populations of dengue viruses

Abstract

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