Distribution of fitness in populations of dengue viruses

Md Abu Choudhury, William B. Lott, John Aaskov

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
26 Downloads (Pure)


Genetically diverse RNA viruses like dengue viruses (DENVs) segregate into multiple, genetically distinct, lineages that temporally arise and disappear on a regular basis. Lineage turnover may occur through multiple processes such as, stochastic or due to variations in fitness. To determine the variation of fitness, we measured the distribution of fitness within DENV populations and correlated it with lineage extinction and replacement. The fitness of most members within a population proved lower than the aggregate fitness of populations from which they were drawn, but lineage replacement events were not associated with changes in the distribution of fitness. These data provide insights into variations in fitness of DENV populations, extending our understanding of the complexity between members of individual populations.

Original languageEnglish
Article numbere107264
Pages (from-to)1-9
Number of pages9
JournalPLoS One
Issue number9
Publication statusPublished - 15 Sept 2014
Externally publishedYes


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