Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes

M. Wilson, R. O'Hanlon, S. Prasad, A. Deighan, P. MacMillan, D. Oxborough, R. Godfrey, G. Smith, A. Maceira, S. Sharma, K. George, G. Whyte

Research output: Contribution to journalArticle

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Abstract

This study examined the cardiac structure and function of a unique cohort of documented lifelong, competitive endurance veteran athletes (>50 yr). Twelve lifelong veteran male endurance athletes [mean ± SD (range) age: 56 ± 6 yr (50-67)], 20 age-matched veteran controls [60 ± 5 yr; (52-69)], and 17 younger male endurance athletes [31 ± 5 yr (26-40)] without significant comorbidities underwent cardiac magnetic resonance (CMR) imaging to assess cardiac morphology and function, as well as CMR imaging with late gadolinium enhancement (LGE) to assess myocardial fibrosis. Lifelong veteran athletes had smaller left (LV) and right ventricular (RV) end-diastolic and end-systolic volumes (P < 0.05), but maintained LV and RV systolic function compared with young athletes. However, veteran athletes had a significantly larger absolute and indexed LV and RV end-diastolic and systolic volumes, intraventricular septum thickness during diastole, posterior wall thickness during diastole, and LV and RV stroke volumes (P < 0.05), together with significantly reduced LV and RV ejection fractions (P < 0.05), compared with veteran controls. In six (50%) of the veteran athletes, LGE of CMR indicated the presence of myocardial fibrosis (4 veteran athletes with LGE of nonspecific cause, 1 probable previous myocarditis, and 1 probable previous silent myocardial infarction). There was no LGE in the age-matched veteran controls or young athletes. The prevalence of LGE in veteran athletes was not associated with age, height, weight, or body surface area (P > 0.05), but was significantly associated with the number of years spent training (P < 0.001), number of competitive marathons (P < 0.001), and ultraendurance (>50 miles) marathons (P < 0.007) completed. An unexpectedly high prevalence of myocardial fibrosis (50%) was observed in healthy, asymptomatic, lifelong veteran male athletes, compared with zero cases in age-matched veteran controls and young athletes. These data suggest a link between lifelong endurance exercise and myocardial fibrosis that requires further investigation.

Original languageEnglish
Pages (from-to)1622-1626
Number of pages5
JournalJournal of Applied Physiology
Volume110
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

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Veterans
Athletes
Fibrosis
Magnetic Resonance Imaging
Gadolinium
Comorbidity
Exercise

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Wilson, M., O'Hanlon, R., Prasad, S., Deighan, A., MacMillan, P., Oxborough, D., ... Whyte, G. (2011). Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. Journal of Applied Physiology, 110(6), 1622-1626. https://doi.org/10.1152/japplphysiol.01280.2010
Wilson, M. ; O'Hanlon, R. ; Prasad, S. ; Deighan, A. ; MacMillan, P. ; Oxborough, D. ; Godfrey, R. ; Smith, G. ; Maceira, A. ; Sharma, S. ; George, K. ; Whyte, G. / Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. In: Journal of Applied Physiology. 2011 ; Vol. 110, No. 6. pp. 1622-1626.
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Wilson, M, O'Hanlon, R, Prasad, S, Deighan, A, MacMillan, P, Oxborough, D, Godfrey, R, Smith, G, Maceira, A, Sharma, S, George, K & Whyte, G 2011, 'Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes', Journal of Applied Physiology, vol. 110, no. 6, pp. 1622-1626. https://doi.org/10.1152/japplphysiol.01280.2010

Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. / Wilson, M.; O'Hanlon, R.; Prasad, S.; Deighan, A.; MacMillan, P.; Oxborough, D.; Godfrey, R.; Smith, G.; Maceira, A.; Sharma, S.; George, K.; Whyte, G.

In: Journal of Applied Physiology, Vol. 110, No. 6, 06.2011, p. 1622-1626.

Research output: Contribution to journalArticle

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AU - Oxborough, D.

AU - Godfrey, R.

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AU - Whyte, G.

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AB - This study examined the cardiac structure and function of a unique cohort of documented lifelong, competitive endurance veteran athletes (>50 yr). Twelve lifelong veteran male endurance athletes [mean ± SD (range) age: 56 ± 6 yr (50-67)], 20 age-matched veteran controls [60 ± 5 yr; (52-69)], and 17 younger male endurance athletes [31 ± 5 yr (26-40)] without significant comorbidities underwent cardiac magnetic resonance (CMR) imaging to assess cardiac morphology and function, as well as CMR imaging with late gadolinium enhancement (LGE) to assess myocardial fibrosis. Lifelong veteran athletes had smaller left (LV) and right ventricular (RV) end-diastolic and end-systolic volumes (P < 0.05), but maintained LV and RV systolic function compared with young athletes. However, veteran athletes had a significantly larger absolute and indexed LV and RV end-diastolic and systolic volumes, intraventricular septum thickness during diastole, posterior wall thickness during diastole, and LV and RV stroke volumes (P < 0.05), together with significantly reduced LV and RV ejection fractions (P < 0.05), compared with veteran controls. In six (50%) of the veteran athletes, LGE of CMR indicated the presence of myocardial fibrosis (4 veteran athletes with LGE of nonspecific cause, 1 probable previous myocarditis, and 1 probable previous silent myocardial infarction). There was no LGE in the age-matched veteran controls or young athletes. The prevalence of LGE in veteran athletes was not associated with age, height, weight, or body surface area (P > 0.05), but was significantly associated with the number of years spent training (P < 0.001), number of competitive marathons (P < 0.001), and ultraendurance (>50 miles) marathons (P < 0.007) completed. An unexpectedly high prevalence of myocardial fibrosis (50%) was observed in healthy, asymptomatic, lifelong veteran male athletes, compared with zero cases in age-matched veteran controls and young athletes. These data suggest a link between lifelong endurance exercise and myocardial fibrosis that requires further investigation.

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Wilson M, O'Hanlon R, Prasad S, Deighan A, MacMillan P, Oxborough D et al. Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. Journal of Applied Physiology. 2011 Jun;110(6):1622-1626. https://doi.org/10.1152/japplphysiol.01280.2010