TY - JOUR
T1 - Do self-reported stress and depressive symptoms effect endothelial function in healthy youth?
T2 - The LOOK longitudinal study
AU - Olive, Lisa S.
AU - Abhayaratna, Walter P.
AU - Byrne, Don
AU - Richardson, Alice
AU - Telford, Richard D.
N1 - Funding Information:
Support for this research was provided via a co-funded National Heart Foundation of Australia (https://www.heartfoundation.org.au)/ National Health and Medical Research Council (https://www.nhmrc.gov.au) Postgraduate Scholarship [GNT1056551] awarded to LO; an Australian Research Council Linkage Grant to DB; and from The Commonwealth Education Trust (New Zealand House, London, UK); (http://www. commonwealth.org.uk/) awarded to DT. Adolescent work was funded by the Canberra Hospital Salaried Staff Specialists Fund awarded to WA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We extend our thanks to the children of the LOOK study for their efforts and ongoing participation; the local government jurisdiction, school principals, teachers, office staff and parents for their willing cooperation.
Publisher Copyright:
© 2018 Olive et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/4/23
Y1 - 2018/4/23
N2 - Background and aims: Endothelial dysfunction is thought to be an early indicator of risk for cardiovascular disease and has been associated with both stress and depression in adults and adolescents. Less is known of these relationships in younger populations, where the origins of CVD is thought to manifest. This study examined the effects of questionnaire derived psychosocial stress and depressive symptoms on endothelial function among children, following them through to adolescence. Method: Participants were 203 grade 2 children (111 girls; M age = 7.6 ± 0.3 years) from the LOOK longitudinal study, who were followed through to adolescence (16 years). Self-reported psychosocial stress and depression were assessed using the validated Children’s Stress Questionnaire and a modified and validated version of the Children’s Depression Inventory respectively; endothelial function was assessed using EndoPAT 2000 system at follow-up only; and adjustments were made for fitness, pubertal development and socioeconomic status. Results: Although all relationships occurred in the hypothesised direction, no cross-sectional or prospective evidence of early symptoms of psychological stress or depression being associated with endothelial dysfunction was found among our asymptomatic cohort of adolescents (all p > .05). Conclusions: In contrast to previous findings in adolescents, our data provided little evidence of any relationship between current or previous psychosocial stress or depression and endothelial function in 16-year-old boys and girls. However, our data need to be interpreted alongside the potential limitations in the sensitivity associated with self-report methods for detecting psychological distress of children.
AB - Background and aims: Endothelial dysfunction is thought to be an early indicator of risk for cardiovascular disease and has been associated with both stress and depression in adults and adolescents. Less is known of these relationships in younger populations, where the origins of CVD is thought to manifest. This study examined the effects of questionnaire derived psychosocial stress and depressive symptoms on endothelial function among children, following them through to adolescence. Method: Participants were 203 grade 2 children (111 girls; M age = 7.6 ± 0.3 years) from the LOOK longitudinal study, who were followed through to adolescence (16 years). Self-reported psychosocial stress and depression were assessed using the validated Children’s Stress Questionnaire and a modified and validated version of the Children’s Depression Inventory respectively; endothelial function was assessed using EndoPAT 2000 system at follow-up only; and adjustments were made for fitness, pubertal development and socioeconomic status. Results: Although all relationships occurred in the hypothesised direction, no cross-sectional or prospective evidence of early symptoms of psychological stress or depression being associated with endothelial dysfunction was found among our asymptomatic cohort of adolescents (all p > .05). Conclusions: In contrast to previous findings in adolescents, our data provided little evidence of any relationship between current or previous psychosocial stress or depression and endothelial function in 16-year-old boys and girls. However, our data need to be interpreted alongside the potential limitations in the sensitivity associated with self-report methods for detecting psychological distress of children.
UR - http://www.scopus.com/inward/record.url?scp=85045925105&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0196137
DO - 10.1371/journal.pone.0196137
M3 - Article
C2 - 29684063
AN - SCOPUS:85045925105
SN - 1932-6203
VL - 13
SP - 1
EP - 13
JO - PLoS One
JF - PLoS One
IS - 4
M1 - 0196137
ER -
