Do self-reported stress and depressive symptoms effect endothelial function in healthy youth?

The LOOK longitudinal study

Lisa S. Olive, Walter P. Abhayaratna, Don Byrne, Alice Richardson, Richard D. Telford

Research output: Contribution to journalArticle

Abstract

Background and aims: Endothelial dysfunction is thought to be an early indicator of risk for cardiovascular disease and has been associated with both stress and depression in adults and adolescents. Less is known of these relationships in younger populations, where the origins of CVD is thought to manifest. This study examined the effects of questionnaire derived psychosocial stress and depressive symptoms on endothelial function among children, following them through to adolescence. Method: Participants were 203 grade 2 children (111 girls; M age = 7.6 ± 0.3 years) from the LOOK longitudinal study, who were followed through to adolescence (16 years). Self-reported psychosocial stress and depression were assessed using the validated Children’s Stress Questionnaire and a modified and validated version of the Children’s Depression Inventory respectively; endothelial function was assessed using EndoPAT 2000 system at follow-up only; and adjustments were made for fitness, pubertal development and socioeconomic status. Results: Although all relationships occurred in the hypothesised direction, no cross-sectional or prospective evidence of early symptoms of psychological stress or depression being associated with endothelial dysfunction was found among our asymptomatic cohort of adolescents (all p > .05). Conclusions: In contrast to previous findings in adolescents, our data provided little evidence of any relationship between current or previous psychosocial stress or depression and endothelial function in 16-year-old boys and girls. However, our data need to be interpreted alongside the potential limitations in the sensitivity associated with self-report methods for detecting psychological distress of children.

Original languageEnglish
Article number0196137
Pages (from-to)1-13
Number of pages13
JournalPLoS One
Volume13
Issue number4
DOIs
Publication statusPublished - 23 Apr 2018

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longitudinal studies
Longitudinal Studies
Depression
Chemical vapor deposition
mental depression
questionnaires
Social Adjustment
socioeconomic status
distress
Psychological Stress
Social Class
Self Report
cardiovascular diseases
Cardiovascular Diseases
Psychology
Equipment and Supplies
methodology
Population

Cite this

Olive, Lisa S. ; Abhayaratna, Walter P. ; Byrne, Don ; Richardson, Alice ; Telford, Richard D. / Do self-reported stress and depressive symptoms effect endothelial function in healthy youth? The LOOK longitudinal study. In: PLoS One. 2018 ; Vol. 13, No. 4. pp. 1-13.
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Do self-reported stress and depressive symptoms effect endothelial function in healthy youth? The LOOK longitudinal study. / Olive, Lisa S.; Abhayaratna, Walter P.; Byrne, Don; Richardson, Alice; Telford, Richard D.

In: PLoS One, Vol. 13, No. 4, 0196137, 23.04.2018, p. 1-13.

Research output: Contribution to journalArticle

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