Abstract
| Original language | English |
|---|---|
| Article number | 345 |
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | BMC Musculoskeletal Disorders |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 10 Nov 2015 |
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Does type 1 diabetes mellitus affect Achilles tendon response to a 10 km run? A case control study Epidemiology of musculoskeletal disorders. / Wong, Andrea; Docking, Sean; Cook, Jill; GAIDA, Jamie.
In: BMC Musculoskeletal Disorders, Vol. 16, No. 1, 345, 10.11.2015, p. 1-7.Research output: Contribution to journal › Article
TY - JOUR
T1 - Does type 1 diabetes mellitus affect Achilles tendon response to a 10 km run? A case control study Epidemiology of musculoskeletal disorders
AU - Wong, Andrea
AU - Docking, Sean
AU - Cook, Jill
AU - GAIDA, Jamie
PY - 2015/11/10
Y1 - 2015/11/10
N2 - Background Achilles tendon structure deteriorates 2-days after maximal loading in elite athletes. The load-response behaviour of tendons may be altered in type 1 diabetes mellitus (T1DM) as hyperglycaemia accelerates collagen cross-linking. This study compared Achilles tendon load-response in participants with T1DM and controls. Methods Achilles tendon structure was quantified at day-0, day-2 and day-4 after a 10 km run. Ultrasound tissue characterisation (UTC) measures tendon structural integrity by classifying pixels as echo-type I, II, III or IV. Echo-type I has the most aligned collagen fibrils and IV has the least. Results Participants were 7 individuals with T1DM and 10 controls. All regularly ran distances greater than 5 km and VISA-A scores indicated good tendon function (T1DM = 94 ± 11, control = 94 ± 10). There were no diabetic complications and HbA1c was 8.7 ± 2.6 mmol/mol for T1DM and 5.3 ± 0.4 mmol/mol for control groups. Baseline tendon structure was similar in T1DM and control groups – UTC echo-types (I-IV) and anterior-posterior thickness were all p > 0.05. No response to load was seen in either T1DM or control group over the 4-days post exercise. Conclusion Active individuals with T1DM do not have a heightened Achilles tendon response to load, which suggests no increased risk of tendon injury. We cannot extrapolate these findings to sedentary individuals with T1DM
AB - Background Achilles tendon structure deteriorates 2-days after maximal loading in elite athletes. The load-response behaviour of tendons may be altered in type 1 diabetes mellitus (T1DM) as hyperglycaemia accelerates collagen cross-linking. This study compared Achilles tendon load-response in participants with T1DM and controls. Methods Achilles tendon structure was quantified at day-0, day-2 and day-4 after a 10 km run. Ultrasound tissue characterisation (UTC) measures tendon structural integrity by classifying pixels as echo-type I, II, III or IV. Echo-type I has the most aligned collagen fibrils and IV has the least. Results Participants were 7 individuals with T1DM and 10 controls. All regularly ran distances greater than 5 km and VISA-A scores indicated good tendon function (T1DM = 94 ± 11, control = 94 ± 10). There were no diabetic complications and HbA1c was 8.7 ± 2.6 mmol/mol for T1DM and 5.3 ± 0.4 mmol/mol for control groups. Baseline tendon structure was similar in T1DM and control groups – UTC echo-types (I-IV) and anterior-posterior thickness were all p > 0.05. No response to load was seen in either T1DM or control group over the 4-days post exercise. Conclusion Active individuals with T1DM do not have a heightened Achilles tendon response to load, which suggests no increased risk of tendon injury. We cannot extrapolate these findings to sedentary individuals with T1DM
KW - Achilles
KW - Exercise
KW - Imaging
KW - T1DM
KW - Tendon
KW - Humans
KW - Middle Aged
KW - Male
KW - Diabetes Mellitus, Type 1/physiopathology
KW - Running/physiology
KW - Case-Control Studies
KW - Adult
KW - Female
KW - Weight-Bearing
KW - Achilles Tendon/physiopathology
UR - http://www.scopus.com/inward/record.url?scp=84946735088&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/type-1-diabetes-mellitus-affect-achilles-tendon-response-10-km-run-case-control-study-epidemiology-m
U2 - 10.1186/s12891-015-0803-z
DO - 10.1186/s12891-015-0803-z
M3 - Article
VL - 16
SP - 1
EP - 7
JO - BMC Musculoskeletal Disorders
JF - BMC Musculoskeletal Disorders
SN - 1471-2474
IS - 1
M1 - 345
ER -