Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery

Wan Nordiana Rahman, Christopher James Wong, Naoto Yagi, Robert Davidson, Moshi Geso

Research output: A Conference proceeding or a Chapter in BookConference contribution

5 Citations (Scopus)

Abstract

Research into the areas of synchrotron generated microbeam radiotherapy (MRT) and stereotactic radiosurgery is increasing. Such MRT techniques are showing potential of tackling some of the more difficult radiotherapy cases such as certain type of brain tumours. Two challenging aspects of these techniques are addressed in this investigation; the difficulty of dose determination and the delivery of the treatments at lower dose levels. In this research polymer gels were used as phantoms and dosimeters and cells were used to confirm outcomes. Normoxic polyacrylamide gels (nPAG) were tested as potential dosimeters for microbeam dosimetry. Following irradiation using microbeam and minibeam radiation from the BL28BU beam-line at Spring-8, Japan, the nPAG were scanned using a Raman spectroscopy technique. Dose enhancement caused by the inclusion of the gold nanoparticles (AuNPs) in the target was investigated using both cells and polymer gels. The use of AuNP could potentially reduce the dose required for the delivery of MRT. In this study it was shown that using endothelial cells with AuNPs, the minimal dose for clear cell killing along the beam line was reduced to 10 Gy. Both studies cell and gel studies indicates significant dose enhancement caused by the gold atoms in the target.

Original languageEnglish
Title of host publication6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010
Pages107-110
Number of pages4
Volume1266
DOIs
Publication statusPublished - 20 Aug 2010
Event6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010 - Melbourne, VIC, Australia
Duration: 15 Feb 201018 Feb 2010

Conference

Conference6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010
CountryAustralia
CityMelbourne, VIC
Period15/02/1018/02/10

Fingerprint

microbeams
dosimeters
synchrotrons
gold
dosage
nanoparticles
gels
augmentation
radiation therapy
delivery
cells
polymers
brain
Japan
tumors
Raman spectroscopy
inclusions
irradiation
radiation
atoms

Cite this

Rahman, W. N., Wong, C. J., Yagi, N., Davidson, R., & Geso, M. (2010). Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery. In 6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010 (Vol. 1266, pp. 107-110) https://doi.org/10.1063/1.3478186
Rahman, Wan Nordiana ; Wong, Christopher James ; Yagi, Naoto ; Davidson, Robert ; Geso, Moshi. / Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery. 6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010. Vol. 1266 2010. pp. 107-110
@inproceedings{f90cd258d0014081abf6651f2856fb63,
title = "Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery",
abstract = "Research into the areas of synchrotron generated microbeam radiotherapy (MRT) and stereotactic radiosurgery is increasing. Such MRT techniques are showing potential of tackling some of the more difficult radiotherapy cases such as certain type of brain tumours. Two challenging aspects of these techniques are addressed in this investigation; the difficulty of dose determination and the delivery of the treatments at lower dose levels. In this research polymer gels were used as phantoms and dosimeters and cells were used to confirm outcomes. Normoxic polyacrylamide gels (nPAG) were tested as potential dosimeters for microbeam dosimetry. Following irradiation using microbeam and minibeam radiation from the BL28BU beam-line at Spring-8, Japan, the nPAG were scanned using a Raman spectroscopy technique. Dose enhancement caused by the inclusion of the gold nanoparticles (AuNPs) in the target was investigated using both cells and polymer gels. The use of AuNP could potentially reduce the dose required for the delivery of MRT. In this study it was shown that using endothelial cells with AuNPs, the minimal dose for clear cell killing along the beam line was reduced to 10 Gy. Both studies cell and gel studies indicates significant dose enhancement caused by the gold atoms in the target.",
keywords = "Gold Nanoparticles, Microbeam Radiotherapy, Polymer Gels dosimetry",
author = "Rahman, {Wan Nordiana} and Wong, {Christopher James} and Naoto Yagi and Robert Davidson and Moshi Geso",
year = "2010",
month = "8",
day = "20",
doi = "10.1063/1.3478186",
language = "English",
isbn = "9780735408135",
volume = "1266",
pages = "107--110",
booktitle = "6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010",

}

Rahman, WN, Wong, CJ, Yagi, N, Davidson, R & Geso, M 2010, Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery. in 6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010. vol. 1266, pp. 107-110, 6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010, Melbourne, VIC, Australia, 15/02/10. https://doi.org/10.1063/1.3478186

Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery. / Rahman, Wan Nordiana; Wong, Christopher James; Yagi, Naoto; Davidson, Robert; Geso, Moshi.

6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010. Vol. 1266 2010. p. 107-110.

Research output: A Conference proceeding or a Chapter in BookConference contribution

TY - GEN

T1 - Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery

AU - Rahman, Wan Nordiana

AU - Wong, Christopher James

AU - Yagi, Naoto

AU - Davidson, Robert

AU - Geso, Moshi

PY - 2010/8/20

Y1 - 2010/8/20

N2 - Research into the areas of synchrotron generated microbeam radiotherapy (MRT) and stereotactic radiosurgery is increasing. Such MRT techniques are showing potential of tackling some of the more difficult radiotherapy cases such as certain type of brain tumours. Two challenging aspects of these techniques are addressed in this investigation; the difficulty of dose determination and the delivery of the treatments at lower dose levels. In this research polymer gels were used as phantoms and dosimeters and cells were used to confirm outcomes. Normoxic polyacrylamide gels (nPAG) were tested as potential dosimeters for microbeam dosimetry. Following irradiation using microbeam and minibeam radiation from the BL28BU beam-line at Spring-8, Japan, the nPAG were scanned using a Raman spectroscopy technique. Dose enhancement caused by the inclusion of the gold nanoparticles (AuNPs) in the target was investigated using both cells and polymer gels. The use of AuNP could potentially reduce the dose required for the delivery of MRT. In this study it was shown that using endothelial cells with AuNPs, the minimal dose for clear cell killing along the beam line was reduced to 10 Gy. Both studies cell and gel studies indicates significant dose enhancement caused by the gold atoms in the target.

AB - Research into the areas of synchrotron generated microbeam radiotherapy (MRT) and stereotactic radiosurgery is increasing. Such MRT techniques are showing potential of tackling some of the more difficult radiotherapy cases such as certain type of brain tumours. Two challenging aspects of these techniques are addressed in this investigation; the difficulty of dose determination and the delivery of the treatments at lower dose levels. In this research polymer gels were used as phantoms and dosimeters and cells were used to confirm outcomes. Normoxic polyacrylamide gels (nPAG) were tested as potential dosimeters for microbeam dosimetry. Following irradiation using microbeam and minibeam radiation from the BL28BU beam-line at Spring-8, Japan, the nPAG were scanned using a Raman spectroscopy technique. Dose enhancement caused by the inclusion of the gold nanoparticles (AuNPs) in the target was investigated using both cells and polymer gels. The use of AuNP could potentially reduce the dose required for the delivery of MRT. In this study it was shown that using endothelial cells with AuNPs, the minimal dose for clear cell killing along the beam line was reduced to 10 Gy. Both studies cell and gel studies indicates significant dose enhancement caused by the gold atoms in the target.

KW - Gold Nanoparticles

KW - Microbeam Radiotherapy

KW - Polymer Gels dosimetry

UR - http://www.scopus.com/inward/record.url?scp=77955600357&partnerID=8YFLogxK

U2 - 10.1063/1.3478186

DO - 10.1063/1.3478186

M3 - Conference contribution

SN - 9780735408135

VL - 1266

SP - 107

EP - 110

BT - 6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010

ER -

Rahman WN, Wong CJ, Yagi N, Davidson R, Geso M. Dosimetry and its enhancement using gold nanoparticles in synchrotron based microbeam and stereotactic radiosurgery. In 6th International Conference on Medical Applications of Synchrotron Radiation, MASR2010. Vol. 1266. 2010. p. 107-110 https://doi.org/10.1063/1.3478186