Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro

Nichole Orr-Burks, Jackelyn Murray, Kyle V. Todd, Abhijeet Bakre, Ralph A. Tripp

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Abstract

Influenza viruses cause respiratory tract infections and substantial health concerns. Infection may result in mild to severe respiratory disease associated with morbidity and some mortality. Several anti-influenza drugs are available, but these agents target viral components and are susceptible to drug resistance. There is a need for new antiviral drug strategies that include repurposing of clinically approved drugs. Drugs that target cellular machinery necessary for influenza virus replication can provide a means for inhibiting influenza virus replication. We used RNA interference screening to identify key host cell genes required for influenza replication, and then FDA-approved drugs that could be repurposed for targeting host genes. We examined the effects of Clopidogrel and Triamterene to inhibit A/WSN/33 (EC50 5.84 uM and 31.48 uM, respectively), A/CA/04/09 (EC50 6.432 uM and 3.32 uM, respectively), and B/Yamagata/16/1988 (EC50 0.28 uM and 0.11 uM, respectively) replication. Clopidogrel and Triamterene provide a druggable approach to influenza treatment across multiple strains and subtypes.

Original languageEnglish
Article numbere0259129
Pages (from-to)1-18
Number of pages18
JournalPLoS One
Volume16
Issue number10 October
DOIs
Publication statusPublished - Oct 2021
Externally publishedYes

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