Duplicity of protein kinase C-O: Novel insights into human T-cell biology

Elissa Sutcliffe, Sudha Rao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design
Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalTranscription
Volume2
Issue number4
DOIs
Publication statusPublished - 2011

Fingerprint

Cytology
T-cells
Protein Kinase C
Cell Biology
Genes
T-Lymphocytes
Drug Design
MicroRNAs
Chromatin
Phosphotransferases
Pharmaceutical Preparations
Therapeutics

Cite this

Sutcliffe, Elissa ; Rao, Sudha. / Duplicity of protein kinase C-O: Novel insights into human T-cell biology. In: Transcription. 2011 ; Vol. 2, No. 4. pp. 189-192.
@article{4494bc8c7062407b9dd8a7a40c473e6e,
title = "Duplicity of protein kinase C-O: Novel insights into human T-cell biology",
abstract = "We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design",
author = "Elissa Sutcliffe and Sudha Rao",
year = "2011",
doi = "10.4161/trns.2.4.16565",
language = "English",
volume = "2",
pages = "189--192",
journal = "Transcription",
issn = "2154-1264",
publisher = "Taylor and Francis Ltd.",
number = "4",

}

Duplicity of protein kinase C-O: Novel insights into human T-cell biology. / Sutcliffe, Elissa; Rao, Sudha.

In: Transcription, Vol. 2, No. 4, 2011, p. 189-192.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Duplicity of protein kinase C-O: Novel insights into human T-cell biology

AU - Sutcliffe, Elissa

AU - Rao, Sudha

PY - 2011

Y1 - 2011

N2 - We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design

AB - We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design

U2 - 10.4161/trns.2.4.16565

DO - 10.4161/trns.2.4.16565

M3 - Article

VL - 2

SP - 189

EP - 192

JO - Transcription

JF - Transcription

SN - 2154-1264

IS - 4

ER -