Duplicity of protein kinase C-O: Novel insights into human T-cell biology

Elissa Sutcliffe, Sudha Rao

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design
    Original languageEnglish
    Pages (from-to)189-192
    Number of pages4
    JournalTranscription
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Cytology
    T-cells
    Protein Kinase C
    Cell Biology
    Genes
    T-Lymphocytes
    Drug Design
    MicroRNAs
    Chromatin
    Phosphotransferases
    Pharmaceutical Preparations
    Therapeutics

    Cite this

    @article{4494bc8c7062407b9dd8a7a40c473e6e,
    title = "Duplicity of protein kinase C-O: Novel insights into human T-cell biology",
    abstract = "We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design",
    author = "Elissa Sutcliffe and Sudha Rao",
    year = "2011",
    doi = "10.4161/trns.2.4.16565",
    language = "English",
    volume = "2",
    pages = "189--192",
    journal = "Transcription",
    issn = "2154-1264",
    publisher = "Taylor and Francis Ltd.",
    number = "4",

    }

    Duplicity of protein kinase C-O: Novel insights into human T-cell biology. / Sutcliffe, Elissa; Rao, Sudha.

    In: Transcription, Vol. 2, No. 4, 2011, p. 189-192.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Duplicity of protein kinase C-O: Novel insights into human T-cell biology

    AU - Sutcliffe, Elissa

    AU - Rao, Sudha

    PY - 2011

    Y1 - 2011

    N2 - We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design

    AB - We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design

    U2 - 10.4161/trns.2.4.16565

    DO - 10.4161/trns.2.4.16565

    M3 - Article

    VL - 2

    SP - 189

    EP - 192

    JO - Transcription

    JF - Transcription

    SN - 2154-1264

    IS - 4

    ER -