Duplicity of protein kinase C-O: Novel insights into human T-cell biology

Elissa Sutcliffe, Sudha Rao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We recently reported on a new wrinkle of complexity in how eukaryotic genes are regulated by providing evidence for a hitherto unknown nuclear function of the signaling kinase, Protein Kinase C-theta (PKC-θ). This chromatin-anchored complex positively regulates inducible immune genes and negatively regulates target miRNA genes. These data challenge the traditional view of mammalian signaling kinases and provides new avenues for therapeutic drug design
Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalTranscription
Volume2
Issue number4
DOIs
Publication statusPublished - 2011

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