TY - JOUR
T1 - EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study)
AU - Lam, Thomas B.L.
AU - MacLennan, Steven
AU - Willemse, Peter Paul M.
AU - Mason, Malcolm D.
AU - Plass, Karin
AU - Shepherd, Robert
AU - Baanders, Ruud
AU - Bangma, Chris H.
AU - Bjartell, Anders
AU - Bossi, Alberto
AU - Briers, Erik
AU - Briganti, Alberto
AU - Buddingh, Karel T.
AU - Catto, James W.F.
AU - Colecchia, Maurizio
AU - Cox, Brett W.
AU - Cumberbatch, Marcus G.
AU - Davies, Jeff
AU - Davis, Niall F.
AU - De Santis, Maria
AU - Dell'Oglio, Paolo
AU - Deschamps, André
AU - Donaldson, James F.
AU - Egawa, Shin
AU - Fankhauser, Christian D.
AU - Fanti, Stefano
AU - Fossati, Nicola
AU - Gandaglia, Giorgio
AU - Gillessen, Silke
AU - Grivas, Nikolaos
AU - Gross, Tobias
AU - Grummet, Jeremy P.
AU - Henry, Ann M.
AU - Ingels, Alexandre
AU - Irani, Jacques
AU - Lardas, Michael
AU - Liew, Matthew
AU - Lin, Daniel W.
AU - Moris, Lisa
AU - Omar, Muhammad Imran
AU - Pang, Karl H.
AU - Paterson, Catherine C.
AU - Renard-Penna, Raphaële
AU - Ribal, Maria J.
AU - Roobol, Monique J.
AU - Rouprêt, Morgan
AU - Rouvière, Olivier
AU - Sancho Pardo, Gemma
AU - Richenberg, Jonathan
AU - Schoots, Ivo G.
AU - Sedelaar, J. P.Michiel
AU - Stricker, Phillip
AU - Tilki, Derya
AU - Vahr Lauridsen, Susanne
AU - van den Bergh, Roderick C.N.
AU - Van den Broeck, Thomas
AU - van der Kwast, Theodorus H.
AU - van der Poel, Henk G.
AU - van Leenders, Geert J.L.H.
AU - Varma, Murali
AU - Violette, Philippe D.
AU - Wallis, Christopher J.D.
AU - Wiegel, Thomas
AU - Wilkinson, Karen
AU - Zattoni, Fabio
AU - N'Dow, James M.O.
AU - Van Poppel, Hendrik
AU - Cornford, Philip
AU - Mottet, Nicolas
N1 - Publisher Copyright:
© 2019
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Background: There is uncertainty in deferred active treatment (DAT) programmes, regarding patient selection, follow-up and monitoring, reclassification, and which outcome measures should be prioritised. Objective: To develop consensus statements for all domains of DAT. Design, setting, and participants: A protocol-driven, three phase study was undertaken by the European Association of Urology (EAU)-European Association of Nuclear Medicine (EANM)-European Society for Radiotherapy and Oncology (ESTRO)-European Association of Urology Section of Urological Research (ESUR)-International Society of Geriatric Oncology (SIOG) Prostate Cancer Guideline Panel in conjunction with partner organisations, including the following: (1) a systematic review to describe heterogeneity across all domains; (2) a two-round Delphi survey involving a large, international panel of stakeholders, including healthcare practitioners (HCPs) and patients; and (3) a consensus group meeting attended by stakeholder group representatives. Robust methods regarding what constituted the consensus were strictly followed. Results and limitations: A total of 109 HCPs and 16 patients completed both survey rounds. Of 129 statements in the survey, consensus was achieved in 66 (51%); the rest of the statements were discussed and voted on in the consensus meeting by 32 HCPs and three patients, where consensus was achieved in additional 27 statements (43%). Overall, 93 statements (72%) achieved consensus in the project. Some uncertainties remained regarding clinically important thresholds for disease extent on biopsy in low-risk disease, and the role of multiparametric magnetic resonance imaging in determining disease stage and aggressiveness as a criterion for inclusion and exclusion. Conclusions: Consensus statements and the findings are expected to guide and inform routine clinical practice and research, until higher levels of evidence emerge through prospective comparative studies and clinical trials. Patient summary: We undertook a project aimed at standardising the elements of practice in active surveillance programmes for early localised prostate cancer because currently there is great variation and uncertainty regarding how best to conduct them. The project involved large numbers of healthcare practitioners and patients using a survey and face-to-face meeting, in order to achieve agreement (ie, consensus) regarding best practice, which will provide guidance to clinicians and researchers.
AB - Background: There is uncertainty in deferred active treatment (DAT) programmes, regarding patient selection, follow-up and monitoring, reclassification, and which outcome measures should be prioritised. Objective: To develop consensus statements for all domains of DAT. Design, setting, and participants: A protocol-driven, three phase study was undertaken by the European Association of Urology (EAU)-European Association of Nuclear Medicine (EANM)-European Society for Radiotherapy and Oncology (ESTRO)-European Association of Urology Section of Urological Research (ESUR)-International Society of Geriatric Oncology (SIOG) Prostate Cancer Guideline Panel in conjunction with partner organisations, including the following: (1) a systematic review to describe heterogeneity across all domains; (2) a two-round Delphi survey involving a large, international panel of stakeholders, including healthcare practitioners (HCPs) and patients; and (3) a consensus group meeting attended by stakeholder group representatives. Robust methods regarding what constituted the consensus were strictly followed. Results and limitations: A total of 109 HCPs and 16 patients completed both survey rounds. Of 129 statements in the survey, consensus was achieved in 66 (51%); the rest of the statements were discussed and voted on in the consensus meeting by 32 HCPs and three patients, where consensus was achieved in additional 27 statements (43%). Overall, 93 statements (72%) achieved consensus in the project. Some uncertainties remained regarding clinically important thresholds for disease extent on biopsy in low-risk disease, and the role of multiparametric magnetic resonance imaging in determining disease stage and aggressiveness as a criterion for inclusion and exclusion. Conclusions: Consensus statements and the findings are expected to guide and inform routine clinical practice and research, until higher levels of evidence emerge through prospective comparative studies and clinical trials. Patient summary: We undertook a project aimed at standardising the elements of practice in active surveillance programmes for early localised prostate cancer because currently there is great variation and uncertainty regarding how best to conduct them. The project involved large numbers of healthcare practitioners and patients using a survey and face-to-face meeting, in order to achieve agreement (ie, consensus) regarding best practice, which will provide guidance to clinicians and researchers.
KW - Active surveillance and monitoring
KW - Clinical practice guidelines
KW - Consensus group meeting
KW - Consensus statements
KW - Deferred treatment with curative intent
KW - Delphi survey
KW - Eligibility
KW - Follow-up
KW - Localised prostate cancer
KW - Outcome measures
KW - Reclassification
UR - http://www.scopus.com/inward/record.url?scp=85072774547&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/eaueanmestroesursiog-prostate-cancer-guideline-panel-consensus-statements-deferred-treatment-curativ
U2 - 10.1016/j.eururo.2019.09.020
DO - 10.1016/j.eururo.2019.09.020
M3 - Article
AN - SCOPUS:85072774547
SN - 0302-2838
VL - 76
SP - 790
EP - 813
JO - European Urology
JF - European Urology
IS - 6
ER -