Effect of dual-focus soft contact lens wear on axial myopia progression in children

Nicola S Anstice, John R Phillips

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

PURPOSE: To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression.

DESIGN: Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. PARTICIPANTS: Forty children, 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71 ± 1.10 diopters (D). METHODS: Dual-Focus lenses had a central zone that corrected refractive error and concentric treatment zones that created 2.00 D of simultaneous myopic retinal defocus during distance and near viewing. Control was a single vision distance (SVD) lens with the same parameters but without treatment zones. Children wore a DF lens in 1 randomly assigned eye and an SVD lens in the fellow eye for 10 months (period 1). Lens assignment was then swapped between eyes, and lenses were worn for a further 10 months (period 2). MAIN OUTCOME MEASURES: Primary outcome was change in SER measured by cycloplegic autorefraction over 10 months. Secondary outcome was a change in axial eye length (AXL) measured by partial coherence interferometry over 10 months. Accommodation wearing DF lenses was assessed using an open-field autorefractor. RESULTS: In period 1, the mean change in SER with DF lenses (-0.44 ± 0.33 D) was less than with SVD lenses (-0.69 ± 0.38 D; P < 0.001); mean increase in AXL was also less with DF lenses (0.11 ± 0.09 mm) than with SVD lenses (0.22 ± 0.10 mm; P < 0.001). In 70% of the children, myopia progression was reduced by 30% or more in the eye wearing the DF lens relative to that wearing the SVD lens. Similar reductions in myopia progression and axial eye elongation were also observed with DF lens wear during period 2. Visual acuity and contrast sensitivity with DF lenses were not significantly different than with SVD lenses. Accommodation to a target at 40 cm was driven through the central distance-correction zone of the DF lens. CONCLUSIONS: Dual-Focus lenses provided normal acuity and contrast sensitivity and allowed accommodation to near targets. Myopia progression and eye elongation were reduced significantly in eyes wearing DF lenses. The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow myopia progression without compromising visual function. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Original languageEnglish
Pages (from-to)1152-1161
Number of pages10
JournalOphthalmology
Volume118
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

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Hydrophilic Contact Lens
Myopia
Lenses
Eye Axial Length
Contrast Sensitivity
Interferometry
Mydriatics
Crystalline Lens

Cite this

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title = "Effect of dual-focus soft contact lens wear on axial myopia progression in children",
abstract = "PURPOSE: To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression.DESIGN: Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. PARTICIPANTS: Forty children, 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71 ± 1.10 diopters (D). METHODS: Dual-Focus lenses had a central zone that corrected refractive error and concentric treatment zones that created 2.00 D of simultaneous myopic retinal defocus during distance and near viewing. Control was a single vision distance (SVD) lens with the same parameters but without treatment zones. Children wore a DF lens in 1 randomly assigned eye and an SVD lens in the fellow eye for 10 months (period 1). Lens assignment was then swapped between eyes, and lenses were worn for a further 10 months (period 2). MAIN OUTCOME MEASURES: Primary outcome was change in SER measured by cycloplegic autorefraction over 10 months. Secondary outcome was a change in axial eye length (AXL) measured by partial coherence interferometry over 10 months. Accommodation wearing DF lenses was assessed using an open-field autorefractor. RESULTS: In period 1, the mean change in SER with DF lenses (-0.44 ± 0.33 D) was less than with SVD lenses (-0.69 ± 0.38 D; P < 0.001); mean increase in AXL was also less with DF lenses (0.11 ± 0.09 mm) than with SVD lenses (0.22 ± 0.10 mm; P < 0.001). In 70{\%} of the children, myopia progression was reduced by 30{\%} or more in the eye wearing the DF lens relative to that wearing the SVD lens. Similar reductions in myopia progression and axial eye elongation were also observed with DF lens wear during period 2. Visual acuity and contrast sensitivity with DF lenses were not significantly different than with SVD lenses. Accommodation to a target at 40 cm was driven through the central distance-correction zone of the DF lens. CONCLUSIONS: Dual-Focus lenses provided normal acuity and contrast sensitivity and allowed accommodation to near targets. Myopia progression and eye elongation were reduced significantly in eyes wearing DF lenses. The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow myopia progression without compromising visual function. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.",
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author = "Anstice, {Nicola S} and Phillips, {John R}",
note = "Copyright {\circledC} 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.",
year = "2011",
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Effect of dual-focus soft contact lens wear on axial myopia progression in children. / Anstice, Nicola S; Phillips, John R.

In: Ophthalmology, Vol. 118, No. 6, 06.2011, p. 1152-1161.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of dual-focus soft contact lens wear on axial myopia progression in children

AU - Anstice, Nicola S

AU - Phillips, John R

N1 - Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

PY - 2011/6

Y1 - 2011/6

N2 - PURPOSE: To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression.DESIGN: Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. PARTICIPANTS: Forty children, 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71 ± 1.10 diopters (D). METHODS: Dual-Focus lenses had a central zone that corrected refractive error and concentric treatment zones that created 2.00 D of simultaneous myopic retinal defocus during distance and near viewing. Control was a single vision distance (SVD) lens with the same parameters but without treatment zones. Children wore a DF lens in 1 randomly assigned eye and an SVD lens in the fellow eye for 10 months (period 1). Lens assignment was then swapped between eyes, and lenses were worn for a further 10 months (period 2). MAIN OUTCOME MEASURES: Primary outcome was change in SER measured by cycloplegic autorefraction over 10 months. Secondary outcome was a change in axial eye length (AXL) measured by partial coherence interferometry over 10 months. Accommodation wearing DF lenses was assessed using an open-field autorefractor. RESULTS: In period 1, the mean change in SER with DF lenses (-0.44 ± 0.33 D) was less than with SVD lenses (-0.69 ± 0.38 D; P < 0.001); mean increase in AXL was also less with DF lenses (0.11 ± 0.09 mm) than with SVD lenses (0.22 ± 0.10 mm; P < 0.001). In 70% of the children, myopia progression was reduced by 30% or more in the eye wearing the DF lens relative to that wearing the SVD lens. Similar reductions in myopia progression and axial eye elongation were also observed with DF lens wear during period 2. Visual acuity and contrast sensitivity with DF lenses were not significantly different than with SVD lenses. Accommodation to a target at 40 cm was driven through the central distance-correction zone of the DF lens. CONCLUSIONS: Dual-Focus lenses provided normal acuity and contrast sensitivity and allowed accommodation to near targets. Myopia progression and eye elongation were reduced significantly in eyes wearing DF lenses. The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow myopia progression without compromising visual function. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

AB - PURPOSE: To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression.DESIGN: Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. PARTICIPANTS: Forty children, 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71 ± 1.10 diopters (D). METHODS: Dual-Focus lenses had a central zone that corrected refractive error and concentric treatment zones that created 2.00 D of simultaneous myopic retinal defocus during distance and near viewing. Control was a single vision distance (SVD) lens with the same parameters but without treatment zones. Children wore a DF lens in 1 randomly assigned eye and an SVD lens in the fellow eye for 10 months (period 1). Lens assignment was then swapped between eyes, and lenses were worn for a further 10 months (period 2). MAIN OUTCOME MEASURES: Primary outcome was change in SER measured by cycloplegic autorefraction over 10 months. Secondary outcome was a change in axial eye length (AXL) measured by partial coherence interferometry over 10 months. Accommodation wearing DF lenses was assessed using an open-field autorefractor. RESULTS: In period 1, the mean change in SER with DF lenses (-0.44 ± 0.33 D) was less than with SVD lenses (-0.69 ± 0.38 D; P < 0.001); mean increase in AXL was also less with DF lenses (0.11 ± 0.09 mm) than with SVD lenses (0.22 ± 0.10 mm; P < 0.001). In 70% of the children, myopia progression was reduced by 30% or more in the eye wearing the DF lens relative to that wearing the SVD lens. Similar reductions in myopia progression and axial eye elongation were also observed with DF lens wear during period 2. Visual acuity and contrast sensitivity with DF lenses were not significantly different than with SVD lenses. Accommodation to a target at 40 cm was driven through the central distance-correction zone of the DF lens. CONCLUSIONS: Dual-Focus lenses provided normal acuity and contrast sensitivity and allowed accommodation to near targets. Myopia progression and eye elongation were reduced significantly in eyes wearing DF lenses. The data suggest that sustained myopic defocus, even when presented to the retina simultaneously with a clear image, can act to slow myopia progression without compromising visual function. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

KW - Accommodation, Ocular/physiology

KW - Adolescent

KW - Child

KW - Contact Lenses, Hydrophilic

KW - Cross-Over Studies

KW - Disease Progression

KW - Equipment Design

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Myopia/physiopathology

KW - Prospective Studies

KW - Refraction, Ocular

KW - Treatment Outcome

KW - Visual Acuity

U2 - 10.1016/j.ophtha.2010.10.035

DO - 10.1016/j.ophtha.2010.10.035

M3 - Article

VL - 118

SP - 1152

EP - 1161

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 6

ER -