TY - JOUR
T1 - Effect of sustained experimental muscle pain on joint position sense
AU - Summers, Simon J.
AU - Schabrun, Siobhan M.
AU - Hirata, Rogerio P.
AU - Graven-Nielsen, Thomas
AU - Cavaleri, Rocco
AU - Chipchase, Lucy S.
N1 - Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Introduction: Joint position sense (JPS) is impaired in clinical musculoskeletal pain conditions, but when this impairment develops in the transition from initial to prolonged pain is not known. Objectives: This study assessed whether progressively developing sustained experimentally induced muscle pain impacts JPS in healthy individuals. Methods: Twenty-eight healthy individuals received injection of nerve growth factor (NGF) into the right extensor carpi radialis brevis muscle on days 0 and 2 to induce sustained pain and hyperalgesia. Wrist JPS was assessed 2 days before day 0 (day -2), before the injection on days 0 and 2, and on days 4 and 14. Joint position sense was quantified as the ability to return the wrist to a neutral position following movements in the direction of radial and ulnar deviation. A 3-dimensional motion analysis system was used to calculate absolute, relative, and joint-angle repositioning errors. Numerical rating scale scores of pain intensity, body chart pain drawings, and pressure pain thresholds (PPTs) were recorded on each day. Results: Compared with baseline, pressure pain thresholds decreased while pain intensity and area increased at day 2 (P < 0.001) and day 4 (P < 0.001) before returning to baseline on day 14 (P > 0.13). Relative to day 0, there was no change in wrist JPS at day 2, 4, and 14 following movements in either target direction (P > 0.05). Conclusion: Despite the presence of sustained muscle pain and hyperalgesia for 4 days at the elbow, no statistical change in wrist joint position error was observed. These findings suggest that pain and hyperalgesia lasting as long as 4 days does not impair JPS.
AB - Introduction: Joint position sense (JPS) is impaired in clinical musculoskeletal pain conditions, but when this impairment develops in the transition from initial to prolonged pain is not known. Objectives: This study assessed whether progressively developing sustained experimentally induced muscle pain impacts JPS in healthy individuals. Methods: Twenty-eight healthy individuals received injection of nerve growth factor (NGF) into the right extensor carpi radialis brevis muscle on days 0 and 2 to induce sustained pain and hyperalgesia. Wrist JPS was assessed 2 days before day 0 (day -2), before the injection on days 0 and 2, and on days 4 and 14. Joint position sense was quantified as the ability to return the wrist to a neutral position following movements in the direction of radial and ulnar deviation. A 3-dimensional motion analysis system was used to calculate absolute, relative, and joint-angle repositioning errors. Numerical rating scale scores of pain intensity, body chart pain drawings, and pressure pain thresholds (PPTs) were recorded on each day. Results: Compared with baseline, pressure pain thresholds decreased while pain intensity and area increased at day 2 (P < 0.001) and day 4 (P < 0.001) before returning to baseline on day 14 (P > 0.13). Relative to day 0, there was no change in wrist JPS at day 2, 4, and 14 following movements in either target direction (P > 0.05). Conclusion: Despite the presence of sustained muscle pain and hyperalgesia for 4 days at the elbow, no statistical change in wrist joint position error was observed. These findings suggest that pain and hyperalgesia lasting as long as 4 days does not impair JPS.
KW - Experimental pain
KW - Joint position sense
KW - Musculoskeletal pain
KW - Nerve growth factor
KW - Proprioception
UR - http://www.scopus.com/inward/record.url?scp=85071093738&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/effect-sustained-experimental-muscle-pain-joint-position-sense
U2 - 10.1097/PR9.0000000000000737
DO - 10.1097/PR9.0000000000000737
M3 - Article
C2 - 31583352
AN - SCOPUS:85071093738
SN - 2471-2531
VL - 4
SP - 1
EP - 8
JO - Pain Reports
JF - Pain Reports
IS - 3
M1 - 737
ER -