Effects of intensive exercise training on immunity in athletes

D. B. Pyne, M. Gteeson

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

A large number of studies have failed to show whether exercise-induced perturbations in immune function are associated with the incidence of infection. "Sports immunology", examining the interaction of physical, psychological and environmental stress on immunity, is emerging as a sub-discipline of sports medicine. A series of studies by our research team has profiled the immune responses of elite swimmers during training. Serum immunoglobulin and IgG subclass levels were lower in swimmers than controls. Suppression of mucosal immune parameters has been associated with the risk of upper respiratory tract infection. Swimmers with a lower pre-season salivary IgA and/or lower pre-exercise salivary IgA level were more likely to contract an URTI during a 7-month training period. In a shorter 12-week study, infected swimmers had a mean salivary IgM concentration that dropped more sharply after a single training session. Significant declines in natural killer cell count and neutrophil oxidative activity were not associated with URTI. Despite systemic and mucosal immunosuppression a cohort of swimmers were also able to mount an antibody response to pneumococcal vaccine equivalent to that of sedentary individuals. Observations of chronic suppression of aspects of host defence and the significant relationship between changes in mucosal immune parameters and URTI, provide a framework for assessment of the immune status of athletes. The underlying causes of upper respiratory tract distress symptoms may be infective, inflammatory or allergic in origin: a differential diagnosis has implications for treatment and management.

Original languageEnglish
Pages (from-to)183-194
Number of pages12
JournalInternational Journal of Sports Medicine
Volume19
Issue numberSUPPL. 3
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Athletes
Immunoglobulin A
Immunity
Exercise
Pneumococcal Vaccines
Sports Medicine
Allergy and Immunology
Psychological Stress
Natural Killer Cells
Respiratory Tract Infections
Respiratory System
Immunosuppression
Antibody Formation
Sports
Immunoglobulin M
Immunoglobulins
Neutrophils
Differential Diagnosis
Cell Count
Immunoglobulin G

Cite this

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Effects of intensive exercise training on immunity in athletes. / Pyne, D. B.; Gteeson, M.

In: International Journal of Sports Medicine, Vol. 19, No. SUPPL. 3, 1998, p. 183-194.

Research output: Contribution to journalArticle

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