Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes

Frady Adly, Ashraf GHANEM

Research output: A Conference proceeding or a Chapter in BookChapter

Abstract

Historically, two approaches have been reported for achieving enantiomerically enriched compounds. The first approach is through asymmetric chemical transformations involving chiral pools, chiral auxiliaries, chiral reagents, and/or enantioselective catalysis/biocatalysis. 1 The second approach is through the preparation of the racemic mixture and the separation of enantiomers by means of chiral separation. 2 These two pathways, however, have their own disadvantages. While the former requires a suitable precursor—auxiliary, reagent, or catalyst—the latter is generally time consuming and yields only up to 50% of the desired enantiomer.
Original languageEnglish
Title of host publicationAsymmetric Synthesis of Drugs and Natural Products
EditorsAhindra Nag
Place of PublicationUSA
PublisherCRC Press
Chapter3
Pages75-131
Number of pages57
ISBN (Print)9781138033610, 9781315302300
Publication statusPublished - Feb 2018

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Adly, F., & GHANEM, A. (2018). Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes. In A. Nag (Ed.), Asymmetric Synthesis of Drugs and Natural Products (pp. 75-131). USA: CRC Press.