Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes

Frady Adly, Ashraf GHANEM

Research output: A Conference proceeding or a Chapter in BookChapterpeer-review


Historically, two approaches have been reported for achieving enantiomerically enriched compounds. The first approach is through asymmetric chemical transformations involving chiral pools, chiral auxiliaries, chiral reagents, and/or enantioselective catalysis/biocatalysis. 1 The second approach is through the preparation of the racemic mixture and the separation of enantiomers by means of chiral separation. 2 These two pathways, however, have their own disadvantages. While the former requires a suitable precursor—auxiliary, reagent, or catalyst—the latter is generally time consuming and yields only up to 50% of the desired enantiomer.
Original languageEnglish
Title of host publicationAsymmetric Synthesis of Drugs and Natural Products
EditorsAhindra Nag
Place of PublicationUSA
PublisherCRC Press
Number of pages57
ISBN (Print)9781138033610, 9781315302300
Publication statusPublished - Feb 2018


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