Historically, two approaches have been reported for achieving enantiomerically enriched compounds. The first approach is through asymmetric chemical transformations involving chiral pools, chiral auxiliaries, chiral reagents, and/or enantioselective catalysis/biocatalysis. 1 The second approach is through the preparation of the racemic mixture and the separation of enantiomers by means of chiral separation. 2 These two pathways, however, have their own disadvantages. While the former requires a suitable precursor—auxiliary, reagent, or catalyst—the latter is generally time consuming and yields only up to 50% of the desired enantiomer.
|Title of host publication||Asymmetric Synthesis of Drugs and Natural Products|
|Place of Publication||USA|
|Number of pages||57|
|ISBN (Print)||9781138033610, 9781315302300|
|Publication status||Published - Feb 2018|
Adly, F., & GHANEM, A. (2018). Enantiomerically Pure Compounds by Enantioselective Synthetic Chiral Metal Complexes. In A. Nag (Ed.), Asymmetric Synthesis of Drugs and Natural Products (pp. 75-131). CRC Press. https://www.taylorfrancis.com/books/e/9781315302300/chapters/10.4201%2F9781315302317-3