Endometriosis and ovulatory disorder: Reduced fertilisation in vitro compared with tubal and unexplained infertility

P. G. Wardle, E. A. Mclaughlin, A. Mcdermott, J. D. Mitchell, B. D. Ray, M. G.R. Hull

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

In-vitro fertilisation (IVF) was carried out once for each of 104 couples who had a single cause of infertility. The group with tubal damage was used as the reference for normal fertilising capacity of both oocytes and sperms: the IVF rates were 68% (71/105) per mature oocyte and 88% (37/42) for couples from whom mature oocytes were recovered. Couples with poor sperm/mucus penetration had reduced IVF rates: 32% (12/38) per oocyte and 60% (9/15) per couple. Sperm function, which was judged normal by means of standard seminal analysis and mucus penetration, was confirmed by normal IVF in unexplained infertility: 63% (37/59) per oocyte and 90% (18/20) per couple. Despite favourable sperm function in their partners, women with endometriosis (without tubal damage) had reduced IVF rates: 33% (19/58) per oocyte and 60% (9/15) per couple. These findings indicate that ovulatory disorder is present in endometriosis and suggest that it causes the associated infertility.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalThe Lancet
Volume326
Issue number8449
DOIs
Publication statusPublished - 3 Aug 1985
Externally publishedYes

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