Enhancement of Latent Fingermarks on Non-Porous Surfaces Using Anti-L-Amino Acid Antibodies Conjugated to Gold Nanoparticles

Xanthe Spindler, Oliver Hofstetter, Andrew McDonagh, Claude Roux, Christopher Lennard

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Anecdotal evidence from forensic practitioners and studies conducted under controlled conditions have indicated that the reaction between 1,2-indanedione and the amino acids present in latent fingermark deposits is highly susceptible to ambient humidity. The addition of catalytic amounts of zinc chloride to the 1,2-indanedione working solution – usually in the order of 1:25 to 1:4 molar ratio (indanedione:zinc) – significantly improves the colour and luminescence of fingermarks treated under dry conditions but appears to have a negligible effect on fingermarks treated in humid environments. The results presented in this paper confirmed that zinc(II) ions added to the 1,2-indanedione working solution act as a Lewis acid catalyst, stabilising a key intermediate during a rate-limiting hydrolysis step. Furthermore, studying the reaction using a chromatography-grade cellulose substrate method previously reported confirmed that cellulose substrates play a major role in facilitating the indanedione-amino acid reaction by acting as a surface catalyst in the early stages of the reaction and by directing the formation of the desired luminescent product (Joullié’s Pink).
Original languageEnglish
Pages (from-to)5602-5604
Number of pages3
JournalChemical Communications
Volume47
Issue number19
DOIs
Publication statusPublished - 2011

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Antibodies
Gold
Amino acids
Cellulose
Zinc
Nanoparticles
Zinc chloride
Amino Acids
Catalysts
Substrates
Chromatography
Luminescence
Hydrolysis
Atmospheric humidity
Deposits
Color
Acids
Ions
Lewis Acids
1,2-indanedione

Cite this

Spindler, Xanthe ; Hofstetter, Oliver ; McDonagh, Andrew ; Roux, Claude ; Lennard, Christopher. / Enhancement of Latent Fingermarks on Non-Porous Surfaces Using Anti-L-Amino Acid Antibodies Conjugated to Gold Nanoparticles. In: Chemical Communications. 2011 ; Vol. 47, No. 19. pp. 5602-5604.
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abstract = "Anecdotal evidence from forensic practitioners and studies conducted under controlled conditions have indicated that the reaction between 1,2-indanedione and the amino acids present in latent fingermark deposits is highly susceptible to ambient humidity. The addition of catalytic amounts of zinc chloride to the 1,2-indanedione working solution – usually in the order of 1:25 to 1:4 molar ratio (indanedione:zinc) – significantly improves the colour and luminescence of fingermarks treated under dry conditions but appears to have a negligible effect on fingermarks treated in humid environments. The results presented in this paper confirmed that zinc(II) ions added to the 1,2-indanedione working solution act as a Lewis acid catalyst, stabilising a key intermediate during a rate-limiting hydrolysis step. Furthermore, studying the reaction using a chromatography-grade cellulose substrate method previously reported confirmed that cellulose substrates play a major role in facilitating the indanedione-amino acid reaction by acting as a surface catalyst in the early stages of the reaction and by directing the formation of the desired luminescent product (Joulli{\'e}’s Pink).",
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Enhancement of Latent Fingermarks on Non-Porous Surfaces Using Anti-L-Amino Acid Antibodies Conjugated to Gold Nanoparticles. / Spindler, Xanthe; Hofstetter, Oliver; McDonagh, Andrew; Roux, Claude; Lennard, Christopher.

In: Chemical Communications, Vol. 47, No. 19, 2011, p. 5602-5604.

Research output: Contribution to journalArticle

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AU - Spindler, Xanthe

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AU - McDonagh, Andrew

AU - Roux, Claude

AU - Lennard, Christopher

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AB - Anecdotal evidence from forensic practitioners and studies conducted under controlled conditions have indicated that the reaction between 1,2-indanedione and the amino acids present in latent fingermark deposits is highly susceptible to ambient humidity. The addition of catalytic amounts of zinc chloride to the 1,2-indanedione working solution – usually in the order of 1:25 to 1:4 molar ratio (indanedione:zinc) – significantly improves the colour and luminescence of fingermarks treated under dry conditions but appears to have a negligible effect on fingermarks treated in humid environments. The results presented in this paper confirmed that zinc(II) ions added to the 1,2-indanedione working solution act as a Lewis acid catalyst, stabilising a key intermediate during a rate-limiting hydrolysis step. Furthermore, studying the reaction using a chromatography-grade cellulose substrate method previously reported confirmed that cellulose substrates play a major role in facilitating the indanedione-amino acid reaction by acting as a surface catalyst in the early stages of the reaction and by directing the formation of the desired luminescent product (Joullié’s Pink).

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