Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy

Wan Nordiana Rahman, Nour Bishara, Trevor Ackerly, Cheng Fa He, Price Jackson, Christopher Wong, Robert Davidson, Moshi Geso

Research output: A Conference proceeding or a Chapter in BookChapter in text book

Abstract

The enhancement of radiation effects by gold nanoparticles (AuNPs) demonstrates the potential application of AuNPs to superficial radiation therapy using kilovoltage X-ray and electron beams. Bovine aortic endothelial cells (BAECs) were used as a model of endothelial tissue. The dose enhancement to BAECs by AuNPs is measured using cell survival as an indicator. Studies were done with kilovoltage superficial radiation therapy-type X-rays and megavoltage electron beams. The chapter investigates cytotoxicity and internalization of AuNPs to the BAEC cellular cytoplasm as a function of AuNP concentration. The dose enhancement factor (DEF) obtained from the cell survival curve is used to determine the effects of AuNPs as dose modifiers. The potential increase of cellular damage by AuNPs was also tested with an electron beam. Similar to the superficial x-ray, the results indicated that under identical radiation doses, cells containing AuNPs showed lower survival percentages with increasing concentration of AuNPs.
Original languageEnglish
Title of host publicationNanomedicine in Cancer
EditorsLajos P. Balogh
Place of PublicationSingapore
PublisherPan Stanford Publishing
Chapter30
Pages737-752
Number of pages16
Volume1
ISBN (Electronic)9781351627498
ISBN (Print)9789814745802
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint Dive into the research topics of 'Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy'. Together they form a unique fingerprint.

Cite this