Entamoeba histolytica protein CaBP3 uses a calcium dependent nuclear localisation pathway in mammalian cells.

Kejun Wei, Reena Ghildyal

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Abstract

Entamoeba histolytica is a major cause of dysentery that leads to a high level of morbidity and mortality, especially in developing countries. Calmodulin-like calcium binding protein EhCaBP3 of E. histolytica is directly involved in disease mechanisms with roles in cytoskeleton dynamics and scission during erythrophagocytosis in a calcium dependent fashion. Interestingly, EhCaBP3 is also present in the nucleus of E. histolytica. We have used a transfected cell system to show that EhCaBP3 is capable of calcium dependent nucleocytoplasmic trafficking. Our data confirms and extends recent findings suggesting presence of a calcium dependent nuclear transport pathway in E. histolytica.
Original languageEnglish
Article numbere53
Pages (from-to)1-8
Number of pages8
JournalExperimental Results
Volume1
DOIs
Publication statusPublished - 24 Nov 2020

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