Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes. Relevance to Differentiating Physiologic Left Ventricular Hypertrophy From Hypertrophic Cardiomyopathy

Sandeep Basavarajaiah, Araceli Boraita, Gregory Whyte, Mathew Wilson, Lorna Carby, Ajay Shah, Sanjay Sharma

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes. Background: The upper limits of left ventricular hypertrophy (LVH) are established in white athletes and aid the differentiation of physiologic LVH from hypertrophic cardiomyopathy (HCM). However, there are few data regarding LV remodeling in black athletes, in whom deaths from HCM are more prevalent. Methods: Between 2003 and 2007, 300 nationally ranked black male athletes (mean age 20.5 years) underwent 12-lead electrocardiogram and 2-dimensional echocardiography. The results were compared with 150 black and white sedentary individuals and 300 highly-trained white male athletes matched for age, size, and sport. Results: Black athletes exhibited greater LV wall thickness and cavity size compared with sedentary black and white individuals. Black athletes had greater LV wall thickness compared with white athletes (11.3 ± 1.6 mm vs. 10 ± 1.5 mm; p < 0.001). In absolute terms, 54 black athletes (18%) had LV wall thickness >12 mm compared with 12 white athletes (4%), and 3% of black athletes exhibited LV wall thickness ≥15 mm compared with none of the white athletes. Black athletes with LVH displayed an enlarged LV cavity and normal diastolic function. Conclusions: Black athletes develop a greater magnitude of LVH compared with white athletes; therefore, extrapolation of conclusions derived from white athletes has the potential of generating false-positive diagnoses of HCM in black athletes.

Original languageEnglish
Pages (from-to)2256-2262
Number of pages7
JournalJournal of the American College of Cardiology
Volume51
Issue number23
DOIs
Publication statusPublished - 10 Jun 2008
Externally publishedYes

Fingerprint

Ventricular Remodeling
Hypertrophic Cardiomyopathy
Left Ventricular Hypertrophy
Athletes

Cite this

Basavarajaiah, Sandeep ; Boraita, Araceli ; Whyte, Gregory ; Wilson, Mathew ; Carby, Lorna ; Shah, Ajay ; Sharma, Sanjay. / Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes. Relevance to Differentiating Physiologic Left Ventricular Hypertrophy From Hypertrophic Cardiomyopathy. In: Journal of the American College of Cardiology. 2008 ; Vol. 51, No. 23. pp. 2256-2262.
@article{a6aae5bdbb4d47de8c7a8c5aeda91eb1,
title = "Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes. Relevance to Differentiating Physiologic Left Ventricular Hypertrophy From Hypertrophic Cardiomyopathy",
abstract = "Objectives: The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes. Background: The upper limits of left ventricular hypertrophy (LVH) are established in white athletes and aid the differentiation of physiologic LVH from hypertrophic cardiomyopathy (HCM). However, there are few data regarding LV remodeling in black athletes, in whom deaths from HCM are more prevalent. Methods: Between 2003 and 2007, 300 nationally ranked black male athletes (mean age 20.5 years) underwent 12-lead electrocardiogram and 2-dimensional echocardiography. The results were compared with 150 black and white sedentary individuals and 300 highly-trained white male athletes matched for age, size, and sport. Results: Black athletes exhibited greater LV wall thickness and cavity size compared with sedentary black and white individuals. Black athletes had greater LV wall thickness compared with white athletes (11.3 ± 1.6 mm vs. 10 ± 1.5 mm; p < 0.001). In absolute terms, 54 black athletes (18{\%}) had LV wall thickness >12 mm compared with 12 white athletes (4{\%}), and 3{\%} of black athletes exhibited LV wall thickness ≥15 mm compared with none of the white athletes. Black athletes with LVH displayed an enlarged LV cavity and normal diastolic function. Conclusions: Black athletes develop a greater magnitude of LVH compared with white athletes; therefore, extrapolation of conclusions derived from white athletes has the potential of generating false-positive diagnoses of HCM in black athletes.",
author = "Sandeep Basavarajaiah and Araceli Boraita and Gregory Whyte and Mathew Wilson and Lorna Carby and Ajay Shah and Sanjay Sharma",
year = "2008",
month = "6",
day = "10",
doi = "10.1016/j.jacc.2007.12.061",
language = "English",
volume = "51",
pages = "2256--2262",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "23",

}

Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes. Relevance to Differentiating Physiologic Left Ventricular Hypertrophy From Hypertrophic Cardiomyopathy. / Basavarajaiah, Sandeep; Boraita, Araceli; Whyte, Gregory; Wilson, Mathew; Carby, Lorna; Shah, Ajay; Sharma, Sanjay.

In: Journal of the American College of Cardiology, Vol. 51, No. 23, 10.06.2008, p. 2256-2262.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes. Relevance to Differentiating Physiologic Left Ventricular Hypertrophy From Hypertrophic Cardiomyopathy

AU - Basavarajaiah, Sandeep

AU - Boraita, Araceli

AU - Whyte, Gregory

AU - Wilson, Mathew

AU - Carby, Lorna

AU - Shah, Ajay

AU - Sharma, Sanjay

PY - 2008/6/10

Y1 - 2008/6/10

N2 - Objectives: The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes. Background: The upper limits of left ventricular hypertrophy (LVH) are established in white athletes and aid the differentiation of physiologic LVH from hypertrophic cardiomyopathy (HCM). However, there are few data regarding LV remodeling in black athletes, in whom deaths from HCM are more prevalent. Methods: Between 2003 and 2007, 300 nationally ranked black male athletes (mean age 20.5 years) underwent 12-lead electrocardiogram and 2-dimensional echocardiography. The results were compared with 150 black and white sedentary individuals and 300 highly-trained white male athletes matched for age, size, and sport. Results: Black athletes exhibited greater LV wall thickness and cavity size compared with sedentary black and white individuals. Black athletes had greater LV wall thickness compared with white athletes (11.3 ± 1.6 mm vs. 10 ± 1.5 mm; p < 0.001). In absolute terms, 54 black athletes (18%) had LV wall thickness >12 mm compared with 12 white athletes (4%), and 3% of black athletes exhibited LV wall thickness ≥15 mm compared with none of the white athletes. Black athletes with LVH displayed an enlarged LV cavity and normal diastolic function. Conclusions: Black athletes develop a greater magnitude of LVH compared with white athletes; therefore, extrapolation of conclusions derived from white athletes has the potential of generating false-positive diagnoses of HCM in black athletes.

AB - Objectives: The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes. Background: The upper limits of left ventricular hypertrophy (LVH) are established in white athletes and aid the differentiation of physiologic LVH from hypertrophic cardiomyopathy (HCM). However, there are few data regarding LV remodeling in black athletes, in whom deaths from HCM are more prevalent. Methods: Between 2003 and 2007, 300 nationally ranked black male athletes (mean age 20.5 years) underwent 12-lead electrocardiogram and 2-dimensional echocardiography. The results were compared with 150 black and white sedentary individuals and 300 highly-trained white male athletes matched for age, size, and sport. Results: Black athletes exhibited greater LV wall thickness and cavity size compared with sedentary black and white individuals. Black athletes had greater LV wall thickness compared with white athletes (11.3 ± 1.6 mm vs. 10 ± 1.5 mm; p < 0.001). In absolute terms, 54 black athletes (18%) had LV wall thickness >12 mm compared with 12 white athletes (4%), and 3% of black athletes exhibited LV wall thickness ≥15 mm compared with none of the white athletes. Black athletes with LVH displayed an enlarged LV cavity and normal diastolic function. Conclusions: Black athletes develop a greater magnitude of LVH compared with white athletes; therefore, extrapolation of conclusions derived from white athletes has the potential of generating false-positive diagnoses of HCM in black athletes.

UR - http://www.scopus.com/inward/record.url?scp=44449157171&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2007.12.061

DO - 10.1016/j.jacc.2007.12.061

M3 - Article

VL - 51

SP - 2256

EP - 2262

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 23

ER -