Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease

Nathan M D'Cunha, Andrew J McKune, Demosthenes B Panagiotakos, Ekavi N Georgousopoulou, Jackson Thomas, Duane D Mellor, Nenad Naumovski

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer's disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk.

    Original languageEnglish
    Pages (from-to)1-18
    Number of pages18
    JournalNutritional Neuroscience
    Volume22
    Issue number1
    DOIs
    Publication statusPublished - 11 Jul 2017

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    Life Style
    Alzheimer Disease
    Biomarkers
    Ketogenic Diet
    Ketone Bodies
    Calcium-Binding Proteins
    Fatty Acids
    Central Nervous System
    Insulin
    Pathology
    Research
    Therapeutics

    Cite this

    D'Cunha, Nathan M ; McKune, Andrew J ; Panagiotakos, Demosthenes B ; Georgousopoulou, Ekavi N ; Thomas, Jackson ; Mellor, Duane D ; Naumovski, Nenad. / Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease. In: Nutritional Neuroscience. 2017 ; Vol. 22, No. 1. pp. 1-18.
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    Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease. / D'Cunha, Nathan M; McKune, Andrew J; Panagiotakos, Demosthenes B; Georgousopoulou, Ekavi N; Thomas, Jackson; Mellor, Duane D; Naumovski, Nenad.

    In: Nutritional Neuroscience, Vol. 22, No. 1, 11.07.2017, p. 1-18.

    Research output: Contribution to journalArticle

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