Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol–water and liposome–water partition coefficients

Teresa Chavez-Capilla, Bill MAHER, Tamsin KELLY, Simon FOSTER

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol–water and liposome–water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome–water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species
Original languageEnglish
Pages (from-to)222-232
Number of pages11
JournalJournal of Environmental Sciences
Volume49
DOIs
Publication statusPublished - 2016

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