Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol–water and liposome–water partition coefficients

Teresa Chavez-Capilla, Bill MAHER, Tamsin KELLY, Simon FOSTER

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    Abstract

    Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol–water and liposome–water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome–water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalJournal of Environmental Sciences
    VolumeOnline
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Arsenic
    Cell membranes
    partition coefficient
    arsenic
    Cell Membrane
    membrane
    Lipid bilayers
    Lipid Bilayers
    arsenate
    Metabolism
    metabolism
    lipid
    Cacodylic Acid
    Biological membranes
    evaluation
    Molecular modeling
    Acids
    Liposomes
    acid
    Membrane Lipids

    Cite this

    @article{19bd6f321f86477184355c10d23f8587,
    title = "Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol–water and liposome–water partition coefficients",
    abstract = "Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol–water and liposome–water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome–water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species",
    author = "Teresa Chavez-Capilla and Bill MAHER and Tamsin KELLY and Simon FOSTER",
    year = "2016",
    doi = "10.1016/j.jes.2016.08.007",
    language = "English",
    volume = "Online",
    pages = "1--11",
    journal = "Huanjing Kexue Xuebao / Acta Scientiae Circumstantiae",
    issn = "0253-2468",
    publisher = "Chinese Academy of Sciences",

    }

    TY - JOUR

    T1 - Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol–water and liposome–water partition coefficients

    AU - Chavez-Capilla, Teresa

    AU - MAHER, Bill

    AU - KELLY, Tamsin

    AU - FOSTER, Simon

    PY - 2016

    Y1 - 2016

    N2 - Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol–water and liposome–water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome–water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species

    AB - Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol–water and liposome–water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome–water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species

    U2 - 10.1016/j.jes.2016.08.007

    DO - 10.1016/j.jes.2016.08.007

    M3 - Article

    VL - Online

    SP - 1

    EP - 11

    JO - Huanjing Kexue Xuebao / Acta Scientiae Circumstantiae

    JF - Huanjing Kexue Xuebao / Acta Scientiae Circumstantiae

    SN - 0253-2468

    ER -