Evidence of the TNF-a system in the human Achilles tendon: expression of TNF-a and TNF receptor at both protein and mRNA levels in the tenocytes.

James Edmund GAIDA; Johan Bagge; Craig Purdam; Jill Cook; Håkan Alfredson; Sture Forsgren

doi:10.1159/000335475

Evidence of the TNF-a system in the human Achilles tendon: expression of TNF-a and TNF receptor at both protein and mRNA levels in the tenocytes.

James Edmund GAIDA, Johan Bagge, Craig Purdam, Jill Cook, Håkan Alfredson, Sture Forsgren

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Understanding adaption to load is essential for prevention and treatment of tendinopathy/tendinosis. Cytokine release in response to load is one mechanism involved in mechanotransduction. The cytokine tumor necrosis factor alpha (TNF-a) is implicated in tendinosis and can induce apoptotic effects via tumor necrosis factor receptor 1 (TNFR1). The complete absence of information concerning the TNF-a system in Achilles tendon is a limitation as mid-portion Achilles tendinosis is very frequent. To examine expression patterns of TNF-a and its two receptors (TNFR1 and TNFR2) in human Achilles tendinosis and control tissue and to biochemically confirm the presence of TNF-a in tendinosis tissue.

Original language	English
Pages (from-to)	339-352
Number of pages	14
Journal	Cells Tissues Organs
Volume	196
Issue number	4
DOIs	https://doi.org/10.1159/000335475
Publication status	Published - 2012
Externally published	Yes

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title = "Evidence of the TNF-a system in the human Achilles tendon: expression of TNF-a and TNF receptor at both protein and mRNA levels in the tenocytes.",

abstract = "Understanding adaption to load is essential for prevention and treatment of tendinopathy/tendinosis. Cytokine release in response to load is one mechanism involved in mechanotransduction. The cytokine tumor necrosis factor alpha (TNF-a) is implicated in tendinosis and can induce apoptotic effects via tumor necrosis factor receptor 1 (TNFR1). The complete absence of information concerning the TNF-a system in Achilles tendon is a limitation as mid-portion Achilles tendinosis is very frequent. To examine expression patterns of TNF-a and its two receptors (TNFR1 and TNFR2) in human Achilles tendinosis and control tissue and to biochemically confirm the presence of TNF-a in tendinosis tissue.",

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T1 - Evidence of the TNF-a system in the human Achilles tendon: expression of TNF-a and TNF receptor at both protein and mRNA levels in the tenocytes.

AU - GAIDA, James Edmund

AU - Bagge, Johan

AU - Purdam, Craig

AU - Cook, Jill

AU - Alfredson, Håkan

AU - Forsgren, Sture

PY - 2012

Y1 - 2012

N2 - Understanding adaption to load is essential for prevention and treatment of tendinopathy/tendinosis. Cytokine release in response to load is one mechanism involved in mechanotransduction. The cytokine tumor necrosis factor alpha (TNF-a) is implicated in tendinosis and can induce apoptotic effects via tumor necrosis factor receptor 1 (TNFR1). The complete absence of information concerning the TNF-a system in Achilles tendon is a limitation as mid-portion Achilles tendinosis is very frequent. To examine expression patterns of TNF-a and its two receptors (TNFR1 and TNFR2) in human Achilles tendinosis and control tissue and to biochemically confirm the presence of TNF-a in tendinosis tissue.

AB - Understanding adaption to load is essential for prevention and treatment of tendinopathy/tendinosis. Cytokine release in response to load is one mechanism involved in mechanotransduction. The cytokine tumor necrosis factor alpha (TNF-a) is implicated in tendinosis and can induce apoptotic effects via tumor necrosis factor receptor 1 (TNFR1). The complete absence of information concerning the TNF-a system in Achilles tendon is a limitation as mid-portion Achilles tendinosis is very frequent. To examine expression patterns of TNF-a and its two receptors (TNFR1 and TNFR2) in human Achilles tendinosis and control tissue and to biochemically confirm the presence of TNF-a in tendinosis tissue.

U2 - 10.1159/000335475

DO - 10.1159/000335475

M3 - Article

SN - 1422-6421

VL - 196

SP - 339

EP - 352

JO - Cells Tissues Organs

JF - Cells Tissues Organs

IS - 4

ER -

Evidence of the TNF-a system in the human Achilles tendon: expression of TNF-a and TNF receptor at both protein and mRNA levels in the tenocytes.

Abstract

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