Evidence of the TNF-a system in the human Achilles tendon: expression of TNF-a and TNF receptor at both protein and mRNA levels in the tenocytes.

James Edmund GAIDA, Johan Bagge, Craig Purdam, Jill Cook, Håkan Alfredson, Sture Forsgren

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Understanding adaption to load is essential for prevention and treatment of tendinopathy/tendinosis. Cytokine release in response to load is one mechanism involved in mechanotransduction. The cytokine tumor necrosis factor alpha (TNF-a) is implicated in tendinosis and can induce apoptotic effects via tumor necrosis factor receptor 1 (TNFR1). The complete absence of information concerning the TNF-a system in Achilles tendon is a limitation as mid-portion Achilles tendinosis is very frequent. To examine expression patterns of TNF-a and its two receptors (TNFR1 and TNFR2) in human Achilles tendinosis and control tissue and to biochemically confirm the presence of TNF-a in tendinosis tissue.
Original languageEnglish
Pages (from-to)339-352
Number of pages14
JournalCells Tissues Organs
Volume196
Issue number4
DOIs
Publication statusPublished - 2012
Externally publishedYes

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