Evolution and comparative analysis of the bat MHC-I region

Justin Ng, Mary Tachedjian, Janine DEAKIN, James W Wynne, Jie Cui, Volker R Haring, Ivano Broz, Honglei Chen, Katherine Belov, Linfa Wang, Michelle L Baker

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    Abstract

    Bats are natural hosts to numerous viruses and have ancient origins, having diverged from other eutherian mammals early in evolution. These characteristics place them in an important position to provide insights into the evolution of the mammalian immune system and antiviral immunity. We describe the first detailed partial map of a bat (Pteropus alecto) MHC-I region with comparative analysis of the MHC-I region and genes. The bat MHC-I region is highly condensed, yet relatively conserved in organisation, and is unusual in that MHC-I genes are present within only one of the three highly conserved class I duplication blocks. We hypothesise that MHC-I genes first originated in the ß duplication block, and subsequently duplicated in a step-wise manner across the MHC-I region during mammalian evolution. Furthermore, bat MHC-I genes contain unique insertions within their peptide-binding grooves potentially affecting the peptide repertoire presented to T cells, which may have implications for the ability of bats to control infection without overt disease.
    Original languageEnglish
    Pages (from-to)1-18
    Number of pages18
    JournalScientific Reports
    Volume6
    Issue numberOnline
    DOIs
    Publication statusPublished - 2016

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    Genes
    Peptides
    Infection Control
    Antiviral Agents
    Mammals
    Immune System
    Immunity
    Viruses
    T-Lymphocytes

    Cite this

    Ng, J., Tachedjian, M., DEAKIN, J., Wynne, J. W., Cui, J., Haring, V. R., ... Baker, M. L. (2016). Evolution and comparative analysis of the bat MHC-I region. Scientific Reports, 6(Online), 1-18. https://doi.org/10.1038/srep21256
    Ng, Justin ; Tachedjian, Mary ; DEAKIN, Janine ; Wynne, James W ; Cui, Jie ; Haring, Volker R ; Broz, Ivano ; Chen, Honglei ; Belov, Katherine ; Wang, Linfa ; Baker, Michelle L. / Evolution and comparative analysis of the bat MHC-I region. In: Scientific Reports. 2016 ; Vol. 6, No. Online. pp. 1-18.
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    abstract = "Bats are natural hosts to numerous viruses and have ancient origins, having diverged from other eutherian mammals early in evolution. These characteristics place them in an important position to provide insights into the evolution of the mammalian immune system and antiviral immunity. We describe the first detailed partial map of a bat (Pteropus alecto) MHC-I region with comparative analysis of the MHC-I region and genes. The bat MHC-I region is highly condensed, yet relatively conserved in organisation, and is unusual in that MHC-I genes are present within only one of the three highly conserved class I duplication blocks. We hypothesise that MHC-I genes first originated in the {\ss} duplication block, and subsequently duplicated in a step-wise manner across the MHC-I region during mammalian evolution. Furthermore, bat MHC-I genes contain unique insertions within their peptide-binding grooves potentially affecting the peptide repertoire presented to T cells, which may have implications for the ability of bats to control infection without overt disease.",
    author = "Justin Ng and Mary Tachedjian and Janine DEAKIN and Wynne, {James W} and Jie Cui and Haring, {Volker R} and Ivano Broz and Honglei Chen and Katherine Belov and Linfa Wang and Baker, {Michelle L}",
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    Ng, J, Tachedjian, M, DEAKIN, J, Wynne, JW, Cui, J, Haring, VR, Broz, I, Chen, H, Belov, K, Wang, L & Baker, ML 2016, 'Evolution and comparative analysis of the bat MHC-I region', Scientific Reports, vol. 6, no. Online, pp. 1-18. https://doi.org/10.1038/srep21256

    Evolution and comparative analysis of the bat MHC-I region. / Ng, Justin; Tachedjian, Mary; DEAKIN, Janine; Wynne, James W; Cui, Jie; Haring, Volker R; Broz, Ivano; Chen, Honglei; Belov, Katherine; Wang, Linfa; Baker, Michelle L.

    In: Scientific Reports, Vol. 6, No. Online, 2016, p. 1-18.

    Research output: Contribution to journalArticle

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    AU - DEAKIN, Janine

    AU - Wynne, James W

    AU - Cui, Jie

    AU - Haring, Volker R

    AU - Broz, Ivano

    AU - Chen, Honglei

    AU - Belov, Katherine

    AU - Wang, Linfa

    AU - Baker, Michelle L

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