TY - JOUR
T1 - Evolutionary and genetic antecedents to the pathogenesis of polycystic ovary syndrome (PCOS)
AU - Parker, Jim
AU - O'Brien, Claire
PY - 2021/3
Y1 - 2021/3
N2 - Polycystic Ovary Syndrome is a clinical condition that effects millions of women worldwide. The pathophysiology of PCOS involves a series of reciprocal feedback mechanisms between biological, metabolic, immune and neuroendocrine systems. It is widely accepted that the pathogenesis of PCOS involves a complex interplay between inherited genetic polymorphisms, developmental epigenetic programming and a wide range of environmental factors that act together to cause the observed pathophysiological changes. International treatment guidelines emphasise the importance of lifestyle interventions as the first priority in the management of patients with PCOS.
AB - Polycystic Ovary Syndrome is a clinical condition that effects millions of women worldwide. The pathophysiology of PCOS involves a series of reciprocal feedback mechanisms between biological, metabolic, immune and neuroendocrine systems. It is widely accepted that the pathogenesis of PCOS involves a complex interplay between inherited genetic polymorphisms, developmental epigenetic programming and a wide range of environmental factors that act together to cause the observed pathophysiological changes. International treatment guidelines emphasise the importance of lifestyle interventions as the first priority in the management of patients with PCOS.
U2 - 10.3316/informit.802596622136498
DO - 10.3316/informit.802596622136498
M3 - Article
SN - 1328-8040
VL - 40
SP - 12
EP - 20
JO - Journal of the Australasian College of Nutritional and Environmental Medicine
JF - Journal of the Australasian College of Nutritional and Environmental Medicine
IS - 1
ER -