Evolutionary and genetic antecedents to the pathogenesis of polycystic ovary syndrome (PCOS)

Polycystic Ovary Syndrome is a clinical condition that effects millions of women worldwide. The pathophysiology of PCOS involves a series of reciprocal feedback mechanisms between biological, metabolic, immune and neuroendocrine systems. It is widely accepted that the pathogenesis of PCOS involves a complex interplay between inherited genetic polymorphisms, developmental epigenetic programming and a wide range of environmental factors that act together to cause the observed pathophysiological changes. International treatment guidelines emphasise the importance of lifestyle interventions as the first priority in the management of patients with PCOS.