Exercise, training, and neutrophil function

John A. Smith, David B. Pyne

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Although neutrophils are critical to host defense, they are also involved in the pathology of various inflammatory diseases. Neutrophils, representing 60% of circulating leukocytes in human subjects, are readily accessible to experimental investigation. Discrete aspects of neutropliil function can be quickly and accurately assessed in vitro using a variety of techniques that involve assessment of intracellular and extracellular functional activities. Moderate exercise lias variable effects on neutrophil function, but intense exercise is potentially immunosuppressive. Endurance training also suppresses most netitrophil functions chronically. A greater understanding of some fundamental aspects of neutrophil function and the uncovering of newly defined roles underlines potential applications in general and sports medicine. However, the practical value of this knowledge for monitoring the health and training programs of elite athletes requires further clarification. The current knowledge of neutrophil and immune functional measurements has not progressed to an extent that routine profiling in athletes can be used diagnostically.

Original languageEnglish
Pages (from-to)96-116
Number of pages21
JournalExercise Immunology Review
Issue number3
Publication statusPublished - 1 Dec 1997
Externally publishedYes

Fingerprint

Neutrophils
Exercise
Athletes
Sports Medicine
Immunosuppressive Agents
Leukocytes
Pathology
Education
Health

Cite this

@article{8db9a0ed63ef4c71aac61c66074bc859,
title = "Exercise, training, and neutrophil function",
abstract = "Although neutrophils are critical to host defense, they are also involved in the pathology of various inflammatory diseases. Neutrophils, representing 60{\%} of circulating leukocytes in human subjects, are readily accessible to experimental investigation. Discrete aspects of neutropliil function can be quickly and accurately assessed in vitro using a variety of techniques that involve assessment of intracellular and extracellular functional activities. Moderate exercise lias variable effects on neutrophil function, but intense exercise is potentially immunosuppressive. Endurance training also suppresses most netitrophil functions chronically. A greater understanding of some fundamental aspects of neutrophil function and the uncovering of newly defined roles underlines potential applications in general and sports medicine. However, the practical value of this knowledge for monitoring the health and training programs of elite athletes requires further clarification. The current knowledge of neutrophil and immune functional measurements has not progressed to an extent that routine profiling in athletes can be used diagnostically.",
author = "Smith, {John A.} and Pyne, {David B.}",
year = "1997",
month = "12",
day = "1",
language = "English",
pages = "96--116",
journal = "Exercise Immunology Review",
issn = "1077-5552",
publisher = "Human Kinetics Publishers Inc.",
number = "3",

}

Exercise, training, and neutrophil function. / Smith, John A.; Pyne, David B.

In: Exercise Immunology Review, No. 3, 01.12.1997, p. 96-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Exercise, training, and neutrophil function

AU - Smith, John A.

AU - Pyne, David B.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Although neutrophils are critical to host defense, they are also involved in the pathology of various inflammatory diseases. Neutrophils, representing 60% of circulating leukocytes in human subjects, are readily accessible to experimental investigation. Discrete aspects of neutropliil function can be quickly and accurately assessed in vitro using a variety of techniques that involve assessment of intracellular and extracellular functional activities. Moderate exercise lias variable effects on neutrophil function, but intense exercise is potentially immunosuppressive. Endurance training also suppresses most netitrophil functions chronically. A greater understanding of some fundamental aspects of neutrophil function and the uncovering of newly defined roles underlines potential applications in general and sports medicine. However, the practical value of this knowledge for monitoring the health and training programs of elite athletes requires further clarification. The current knowledge of neutrophil and immune functional measurements has not progressed to an extent that routine profiling in athletes can be used diagnostically.

AB - Although neutrophils are critical to host defense, they are also involved in the pathology of various inflammatory diseases. Neutrophils, representing 60% of circulating leukocytes in human subjects, are readily accessible to experimental investigation. Discrete aspects of neutropliil function can be quickly and accurately assessed in vitro using a variety of techniques that involve assessment of intracellular and extracellular functional activities. Moderate exercise lias variable effects on neutrophil function, but intense exercise is potentially immunosuppressive. Endurance training also suppresses most netitrophil functions chronically. A greater understanding of some fundamental aspects of neutrophil function and the uncovering of newly defined roles underlines potential applications in general and sports medicine. However, the practical value of this knowledge for monitoring the health and training programs of elite athletes requires further clarification. The current knowledge of neutrophil and immune functional measurements has not progressed to an extent that routine profiling in athletes can be used diagnostically.

UR - http://www.scopus.com/inward/record.url?scp=0030955978&partnerID=8YFLogxK

M3 - Article

SP - 96

EP - 116

JO - Exercise Immunology Review

JF - Exercise Immunology Review

SN - 1077-5552

IS - 3

ER -