Exosome-mediated human norovirus infection

Kyle V. Todd, Ralph A. Tripp

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV infection. HuNoV is contained within stool-derived exosomes, and exosome-associated HuNoV has been shown to replicate in human intestinal enteroids. In this study, we examine exosome-associated HuNoV infection of Vero cells and show that exosomes containing HuNoV may attach, infect, and be passaged in Vero cells. These findings support earlier findings and have implications for developing HuNoV disease intervention strategies.

Original languageEnglish
Article numbere0237044
Pages (from-to)1-8
Number of pages8
JournalPLoS One
Volume15
Issue number8
DOIs
Publication statusPublished - 2020
Externally publishedYes

Fingerprint

Dive into the research topics of 'Exosome-mediated human norovirus infection'. Together they form a unique fingerprint.

Cite this