Exosome-mediated human norovirus infection

Kyle V. Todd, Ralph A. Tripp

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
20 Downloads (Pure)


Human norovirus (HuNoV) is a leading cause of acute gastroenteritis. Outbreaks normally occur via the fecal-oral route. HuNoV infection is thought to occur by viral particle transmission, but increasing evidence suggests a function for exosomes in HuNoV infection. HuNoV is contained within stool-derived exosomes, and exosome-associated HuNoV has been shown to replicate in human intestinal enteroids. In this study, we examine exosome-associated HuNoV infection of Vero cells and show that exosomes containing HuNoV may attach, infect, and be passaged in Vero cells. These findings support earlier findings and have implications for developing HuNoV disease intervention strategies.

Original languageEnglish
Article numbere0237044
Pages (from-to)1-8
Number of pages8
JournalPLoS One
Issue number8
Publication statusPublished - 2020
Externally publishedYes


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