Exposure-dose-response of Anadara trapezia to metal contaminated estuarine sediments 3. Selenium spiked sediments

Anne Taylor, William Maher

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Selenium enters near shore marine environments from the activities of coal-fired power stations. Although selenium is an essential element, at elevated concentrations it can cause genotoxic damage. The relationship between selenium exposure dose and response was investigated in Anadara trapezia exposed to selenium spiked sediment (5 g/g and 20 g/g dry mass) for 56 days. A. trapezia reached an equilibrium selenium tissue concentration (2 g/g and 10 g/g respectively) by day 42. Gills had significantly more selenium than the hepatopancreas and haemolymph. Between 12 and 21% of accumulated selenium in the gill and hepatopancreas was detoxified and in the metal rich granule. Most of the biologically active selenium in both tissues was in the mitochondrial fraction. Glutathione peroxidase activity and mean total glutathione concentrations for selenium exposed organisms were not significantly different to controls. The ratio of reduced to oxidised glutathione and the total antioxidant capacity were significantly reduced in selenium exposed organisms compared to control organisms. Increased selenium exposure resulted in significant increases in lipid peroxidation, lysosomal destabilisation and an increased frequency of micronuclei. A significant exposureâ¿¿doseâ¿¿response relationship for A. trapezia exposed to selenium enriched sediments indicates that elevated sediment selenium concentrations can increased biologically active selenium burdens and cause impairment of cellular processes and cell integrity.
    Original languageEnglish
    Pages (from-to)152-162
    Number of pages11
    JournalAquatic Toxicology
    Volume124-125
    DOIs
    Publication statusPublished - 2012

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    Arcidae
    Anadara
    estuarine sediments
    estuarine sediment
    Selenium
    selenium
    dose response
    Metals
    metals
    sediments
    metal
    sediment
    Hepatopancreas
    hepatopancreas
    exposure
    dose
    glutathione
    gills
    organisms

    Cite this

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    title = "Exposure-dose-response of Anadara trapezia to metal contaminated estuarine sediments 3. Selenium spiked sediments",
    abstract = "Selenium enters near shore marine environments from the activities of coal-fired power stations. Although selenium is an essential element, at elevated concentrations it can cause genotoxic damage. The relationship between selenium exposure dose and response was investigated in Anadara trapezia exposed to selenium spiked sediment (5 g/g and 20 g/g dry mass) for 56 days. A. trapezia reached an equilibrium selenium tissue concentration (2 g/g and 10 g/g respectively) by day 42. Gills had significantly more selenium than the hepatopancreas and haemolymph. Between 12 and 21{\%} of accumulated selenium in the gill and hepatopancreas was detoxified and in the metal rich granule. Most of the biologically active selenium in both tissues was in the mitochondrial fraction. Glutathione peroxidase activity and mean total glutathione concentrations for selenium exposed organisms were not significantly different to controls. The ratio of reduced to oxidised glutathione and the total antioxidant capacity were significantly reduced in selenium exposed organisms compared to control organisms. Increased selenium exposure resulted in significant increases in lipid peroxidation, lysosomal destabilisation and an increased frequency of micronuclei. A significant exposure{\^a}¿¿dose{\^a}¿¿response relationship for A. trapezia exposed to selenium enriched sediments indicates that elevated sediment selenium concentrations can increased biologically active selenium burdens and cause impairment of cellular processes and cell integrity.",
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    author = "Anne Taylor and William Maher",
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    Exposure-dose-response of Anadara trapezia to metal contaminated estuarine sediments 3. Selenium spiked sediments. / Taylor, Anne; Maher, William.

    In: Aquatic Toxicology, Vol. 124-125, 2012, p. 152-162.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Exposure-dose-response of Anadara trapezia to metal contaminated estuarine sediments 3. Selenium spiked sediments

    AU - Taylor, Anne

    AU - Maher, William

    PY - 2012

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    N2 - Selenium enters near shore marine environments from the activities of coal-fired power stations. Although selenium is an essential element, at elevated concentrations it can cause genotoxic damage. The relationship between selenium exposure dose and response was investigated in Anadara trapezia exposed to selenium spiked sediment (5 g/g and 20 g/g dry mass) for 56 days. A. trapezia reached an equilibrium selenium tissue concentration (2 g/g and 10 g/g respectively) by day 42. Gills had significantly more selenium than the hepatopancreas and haemolymph. Between 12 and 21% of accumulated selenium in the gill and hepatopancreas was detoxified and in the metal rich granule. Most of the biologically active selenium in both tissues was in the mitochondrial fraction. Glutathione peroxidase activity and mean total glutathione concentrations for selenium exposed organisms were not significantly different to controls. The ratio of reduced to oxidised glutathione and the total antioxidant capacity were significantly reduced in selenium exposed organisms compared to control organisms. Increased selenium exposure resulted in significant increases in lipid peroxidation, lysosomal destabilisation and an increased frequency of micronuclei. A significant exposureâ¿¿doseâ¿¿response relationship for A. trapezia exposed to selenium enriched sediments indicates that elevated sediment selenium concentrations can increased biologically active selenium burdens and cause impairment of cellular processes and cell integrity.

    AB - Selenium enters near shore marine environments from the activities of coal-fired power stations. Although selenium is an essential element, at elevated concentrations it can cause genotoxic damage. The relationship between selenium exposure dose and response was investigated in Anadara trapezia exposed to selenium spiked sediment (5 g/g and 20 g/g dry mass) for 56 days. A. trapezia reached an equilibrium selenium tissue concentration (2 g/g and 10 g/g respectively) by day 42. Gills had significantly more selenium than the hepatopancreas and haemolymph. Between 12 and 21% of accumulated selenium in the gill and hepatopancreas was detoxified and in the metal rich granule. Most of the biologically active selenium in both tissues was in the mitochondrial fraction. Glutathione peroxidase activity and mean total glutathione concentrations for selenium exposed organisms were not significantly different to controls. The ratio of reduced to oxidised glutathione and the total antioxidant capacity were significantly reduced in selenium exposed organisms compared to control organisms. Increased selenium exposure resulted in significant increases in lipid peroxidation, lysosomal destabilisation and an increased frequency of micronuclei. A significant exposureâ¿¿doseâ¿¿response relationship for A. trapezia exposed to selenium enriched sediments indicates that elevated sediment selenium concentrations can increased biologically active selenium burdens and cause impairment of cellular processes and cell integrity.

    KW - Selenium

    KW - Biomarkers

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    KW - Biologically active selenium

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