Exposure-dose-response of Tellina deltoidalis to metal-contaminated estuarine sediments 1. Cadmium spiked sediments

Anne Taylor, William Maher

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    Abstract

    Cadmium is a ubiquitous environmental metal contaminant with an affinity for biological membranes; it can enter cells by facilitated transport and it binds therein to various biomolecules and affects membrane system function. The relationship between cadmium exposure, dose and response was investigated in the benthic, deposit feeding, marine bivalve Tellina deltoidalis, using 28 day microcosm spiked cadmium exposures. Tissue cadmium reached steady state with the exposure concentration. Half the accumulated cadmium was detoxified and with increased exposure more was converted into metal rich granules. Most biologically active cadmium was in the mitochondrial fraction, with up to 7320-fold cadmium increases in exposed organisms. Cadmium exposed T. deltoidalis generally had reduced glutathione peroxidase enzymeactivity. An increase in total glutathione concentrations, due to a build up of oxidised glutathione, was indicated by the reduced to oxidised glutathione ratio. All cadmiumexposed T. deltoidalis had reduced total antioxidant capacity that corresponded with increased lipid peroxidation, lysosomal destabilisation and micronuclei frequency. Clear exposure-dose-response relationships have been demonstrated for T. deltoidalis exposed to cadmium-spiked sediments, supporting this organism's suitability for laboratory or in situ evaluation of sediment cadmium toxicity.
    Original languageEnglish
    Pages (from-to)44-55
    Number of pages12
    JournalComparative Biochemistry and Physiology. Part C: Toxicology Pharmacology
    Volume158
    DOIs
    Publication statusPublished - 2013

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    Cadmium
    Sediments
    Metals
    Glutathione Disulfide
    Glutathione
    Biological membranes
    Membranes
    Bivalvia
    Biomolecules
    Glutathione Peroxidase
    Lipid Peroxidation
    Toxicity
    Deposits
    Antioxidants
    Impurities
    Tissue
    Lipids

    Cite this

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    title = "Exposure-dose-response of Tellina deltoidalis to metal-contaminated estuarine sediments 1. Cadmium spiked sediments",
    abstract = "Cadmium is a ubiquitous environmental metal contaminant with an affinity for biological membranes; it can enter cells by facilitated transport and it binds therein to various biomolecules and affects membrane system function. The relationship between cadmium exposure, dose and response was investigated in the benthic, deposit feeding, marine bivalve Tellina deltoidalis, using 28 day microcosm spiked cadmium exposures. Tissue cadmium reached steady state with the exposure concentration. Half the accumulated cadmium was detoxified and with increased exposure more was converted into metal rich granules. Most biologically active cadmium was in the mitochondrial fraction, with up to 7320-fold cadmium increases in exposed organisms. Cadmium exposed T. deltoidalis generally had reduced glutathione peroxidase enzymeactivity. An increase in total glutathione concentrations, due to a build up of oxidised glutathione, was indicated by the reduced to oxidised glutathione ratio. All cadmiumexposed T. deltoidalis had reduced total antioxidant capacity that corresponded with increased lipid peroxidation, lysosomal destabilisation and micronuclei frequency. Clear exposure-dose-response relationships have been demonstrated for T. deltoidalis exposed to cadmium-spiked sediments, supporting this organism's suitability for laboratory or in situ evaluation of sediment cadmium toxicity.",
    keywords = "Subcellular, Oxidative stress, Lysosomes, Micronuclei, Bivalve.",
    author = "Anne Taylor and William Maher",
    year = "2013",
    doi = "10.1016/j.cbpc.2013.04.005",
    language = "English",
    volume = "158",
    pages = "44--55",
    journal = "Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology",
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    TY - JOUR

    T1 - Exposure-dose-response of Tellina deltoidalis to metal-contaminated estuarine sediments 1. Cadmium spiked sediments

    AU - Taylor, Anne

    AU - Maher, William

    PY - 2013

    Y1 - 2013

    N2 - Cadmium is a ubiquitous environmental metal contaminant with an affinity for biological membranes; it can enter cells by facilitated transport and it binds therein to various biomolecules and affects membrane system function. The relationship between cadmium exposure, dose and response was investigated in the benthic, deposit feeding, marine bivalve Tellina deltoidalis, using 28 day microcosm spiked cadmium exposures. Tissue cadmium reached steady state with the exposure concentration. Half the accumulated cadmium was detoxified and with increased exposure more was converted into metal rich granules. Most biologically active cadmium was in the mitochondrial fraction, with up to 7320-fold cadmium increases in exposed organisms. Cadmium exposed T. deltoidalis generally had reduced glutathione peroxidase enzymeactivity. An increase in total glutathione concentrations, due to a build up of oxidised glutathione, was indicated by the reduced to oxidised glutathione ratio. All cadmiumexposed T. deltoidalis had reduced total antioxidant capacity that corresponded with increased lipid peroxidation, lysosomal destabilisation and micronuclei frequency. Clear exposure-dose-response relationships have been demonstrated for T. deltoidalis exposed to cadmium-spiked sediments, supporting this organism's suitability for laboratory or in situ evaluation of sediment cadmium toxicity.

    AB - Cadmium is a ubiquitous environmental metal contaminant with an affinity for biological membranes; it can enter cells by facilitated transport and it binds therein to various biomolecules and affects membrane system function. The relationship between cadmium exposure, dose and response was investigated in the benthic, deposit feeding, marine bivalve Tellina deltoidalis, using 28 day microcosm spiked cadmium exposures. Tissue cadmium reached steady state with the exposure concentration. Half the accumulated cadmium was detoxified and with increased exposure more was converted into metal rich granules. Most biologically active cadmium was in the mitochondrial fraction, with up to 7320-fold cadmium increases in exposed organisms. Cadmium exposed T. deltoidalis generally had reduced glutathione peroxidase enzymeactivity. An increase in total glutathione concentrations, due to a build up of oxidised glutathione, was indicated by the reduced to oxidised glutathione ratio. All cadmiumexposed T. deltoidalis had reduced total antioxidant capacity that corresponded with increased lipid peroxidation, lysosomal destabilisation and micronuclei frequency. Clear exposure-dose-response relationships have been demonstrated for T. deltoidalis exposed to cadmium-spiked sediments, supporting this organism's suitability for laboratory or in situ evaluation of sediment cadmium toxicity.

    KW - Subcellular

    KW - Oxidative stress

    KW - Lysosomes

    KW - Micronuclei

    KW - Bivalve.

    U2 - 10.1016/j.cbpc.2013.04.005

    DO - 10.1016/j.cbpc.2013.04.005

    M3 - Article

    VL - 158

    SP - 44

    EP - 55

    JO - Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology

    JF - Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology

    SN - 1532-0456

    ER -